DegronMD - P49757(NUMB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P633S	TCGA-13-0791	OV	TCGA	FEAQWAAL	DEG_MDM2_SWIB_1	616:623	Mutation rewiring degron network	0.0556
p.R630H	TCGA-AX-A2HD	UCEC	TCGA	FEAQWAAL	DEG_MDM2_SWIB_1	616:623	Mutation rewiring degron network	0.1389
p.R630H	SIDM01181	Hepatocellular Carcinoma	GDSC	FEAQWAAL	DEG_MDM2_SWIB_1	616:623	Mutation rewiring degron network	0.1389
p.R630H	SNU-398	liver	COSMIC	FEAQWAAL	DEG_MDM2_SWIB_1	616:623	Mutation rewiring degron network	0.1389
p.K626Q	TCGA-D8-A1JP	BRCA	TCGA	FEAQWAAL	DEG_MDM2_SWIB_1	616:623	Mutation substituting flanking lysine	0.3611
p.S627F	TCGA-W3-AA1R	SKCM	TCGA	FEAQWAAL	DEG_MDM2_SWIB_1	616:623	Mutation rewiring degron network	0.2222
p.A622V	SIDM01169	Ovarian Carcinoma	GDSC	FEAQWAAL	DEG_MDM2_SWIB_1	616:623	Mutation altering degron motif	0.5825
p.A622V	TOV-21G	ovary	COSMIC	FEAQWAAL	DEG_MDM2_SWIB_1	616:623	Mutation altering degron motif	0.5825
p.A611V	TOV-21G	ovary	COSMIC	FEAQWAAL	DEG_MDM2_SWIB_1	616:623	Mutation rewiring degron network	0.1944
p.S629F	KYSE-510	oesophagus	COSMIC	FEAQWAAL	DEG_MDM2_SWIB_1	616:623	Mutation rewiring degron network	0.1667
p.T631S	NCI-H1092	lung	COSMIC	FEAQWAAL	DEG_MDM2_SWIB_1	616:623	Mutation blocking phosphorylation signal	0.5556
p.R619H	SNU-398	liver	COSMIC	FEAQWAAL	DEG_MDM2_SWIB_1	616:623	Mutation altering degron motif	0.8244
p.T620S	NCI-H1092	lung	COSMIC	FEAQWAAL	DEG_MDM2_SWIB_1	616:623	Mutation altering degron motif	0.7116

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons