DegronMD - Q12815(TROAP)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E565K	TCGA-13-0794	OV	TCGA	ESSRQEQLEVPEP	DEG_COP1_1	568:580	Mutation rewiring degron network	0.25
p.E573G	TCGA-23-1123	OV	TCGA	ESSRQEQLEVPEP	DEG_COP1_1	568:580	Mutation altering degron motif	0.7199
p.E596K	TCGA-49-6742	LUAD	TCGA	ESSRQEQLEVPEP	DEG_COP1_1	601:613	Mutation rewiring degron network	0.1944
p.E596K	DO25622	LUAD	ICGC	ESSRQEQLEVPEP	DEG_COP1_1	601:613	Mutation rewiring degron network	0.1944
p.E546D	TCGA-49-6767	LUAD	TCGA	SLQEQLEVPEP	DEG_COP1_1	537:547	Mutation altering degron motif	0.5647
p.P660L	TCGA-55-7573	LUAD	TCGA	PATTS	DEG_SPOP_SBC_1	667:671	Mutation rewiring degron network	0.1389
p.V577L	TCGA-60-2714	LUSC	TCGA	ESSRQEQLEVPEP	DEG_COP1_1	568:580	Mutation altering degron motif	0.6765
p.R571H	TCGA-A5-A0G1	UCEC	TCGA	ESSRQEQLEVPEP	DEG_COP1_1	568:580	Mutation altering degron motif	0.7133
p.R571H	TCGA-AJ-A2QO	UCEC	TCGA	ESSRQEQLEVPEP	DEG_COP1_1	568:580	Mutation altering degron motif	0.7133
p.E590K	TCGA-A5-A0G1	UCEC	TCGA	ESSRQEQLEVPEP	DEG_COP1_1	568:580	Mutation rewiring degron network	0.0556
p.E590K	DO42472	UCEC	ICGC	ESSRQEQLEVPEP	DEG_COP1_1	568:580	Mutation rewiring degron network	0.0556
p.E590K	SIDM00118	Colorectal Carcinoma	GDSC	ESSRQEQLEVPEP	DEG_COP1_1	568:580	Mutation rewiring degron network	0.0556
p.E590K	ACH-001081	Colon/Colorectal Cancer	CCLE	ESSRQEQLEVPEP	DEG_COP1_1	568:580	Mutation rewiring degron network	0.0556
p.E590K	HCC2998	large intestine	COSMIC	ESSRQEQLEVPEP	DEG_COP1_1	568:580	Mutation rewiring degron network	0.0556
p.P549H	TCGA-AA-3715	COAD	TCGA	SLQEQLEVPEP	DEG_COP1_1	537:547	Mutation rewiring degron network	0.2778
p.S86I	TCGA-AN-A0AR	BRCA	TCGA	PRNPLEELR	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2778
p.S86I	DO4731	BRCA	ICGC	PRNPLEELR	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2778
p.P619L	TCGA-AP-A1DV	UCEC	TCGA	ESSRQEQLEVPEP	DEG_COP1_1	601:613	Mutation rewiring degron network	0.1667
p.R89Q	TCGA-AX-A1CE	UCEC	TCGA	PRNPLEELR	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.7329
p.R89Q	DO42280	UCEC	ICGC	PRNPLEELR	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.7329
p.S591P	TCGA-AZ-6601	COAD	TCGA	ESSRQEQLEVPEP	DEG_COP1_1	601:613	Mutation rewiring degron network	0.0556
p.S591P	DO8119	COAD	ICGC	ESSRQEQLEVPEP	DEG_COP1_1	601:613	Mutation rewiring degron network	0.0556
p.P619H	TCGA-BR-8081	STAD	TCGA	ESSRQEQLEVPEP	DEG_COP1_1	601:613	Mutation rewiring degron network	0.1667
p.E565D	TCGA-BT-A3PJ	BLCA	TCGA	ESSRQEQLEVPEP	DEG_COP1_1	568:580	Mutation rewiring degron network	0.25
p.S675C	TCGA-C8-A137	BRCA	TCGA	PATTS	DEG_SPOP_SBC_1	667:671	Mutation rewiring degron network	0.2222
p.R594M	TCGA-EE-A2MG	SKCM	TCGA	ESSRQEQLEVPEP	DEG_COP1_1	601:613	Mutation rewiring degron network	0.1389
p.R594M	DO37421	SKCM	ICGC	ESSRQEQLEVPEP	DEG_COP1_1	601:613	Mutation rewiring degron network	0.1389
p.Q539E	TCGA-ER-A19G	SKCM	TCGA	SLQEQLEVPEP	DEG_COP1_1	537:547	Mutation altering degron motif	0.5633
p.N90H	TCGA-G7-6795	KIRP	TCGA	PRNPLEELR	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.6312
p.N90H	DO20851	KIRP	ICGC	PRNPLEELR	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.6312
p.P597H	TCGA-HU-A4GU	STAD	TCGA	ESSRQEQLEVPEP	DEG_COP1_1	601:613	Mutation rewiring degron network	0.2222
p.P597H	DO47849	STAD	ICGC	ESSRQEQLEVPEP	DEG_COP1_1	601:613	Mutation rewiring degron network	0.2222
p.E532D	TCGA-YD-A9TA	SKCM	TCGA	SLQEQLEVPEP	DEG_COP1_1	537:547	Mutation rewiring degron network	0.1944
p.D91H	DO44033	BLCA	ICGC	PRNPLEELR	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.7688
p.E596A	DO233885	GACA	ICGC	ESSRQEQLEVPEP	DEG_COP1_1	601:613	Mutation rewiring degron network	0.1944
p.W96C	DO52060	HNSC	ICGC	PRNPLEELR	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.7
p.I595S	DO228902	LICA	ICGC	ESSRQEQLEVPEP	DEG_COP1_1	601:613	Mutation rewiring degron network	0.1667
p.I595S	DO230529	LUSC	ICGC	ESSRQEQLEVPEP	DEG_COP1_1	601:613	Mutation rewiring degron network	0.1667
p.I595S	DO231176	LUSC	ICGC	ESSRQEQLEVPEP	DEG_COP1_1	601:613	Mutation rewiring degron network	0.1667
p.I595S	ACH-000352	Breast Cancer	CCLE	ESSRQEQLEVPEP	DEG_COP1_1	601:613	Mutation rewiring degron network	0.1667
p.Y592C	DO228902	LICA	ICGC	ESSRQEQLEVPEP	DEG_COP1_1	601:613	Mutation rewiring degron network	0.0833
p.Y592C	DO229055	LICA	ICGC	ESSRQEQLEVPEP	DEG_COP1_1	601:613	Mutation rewiring degron network	0.0833
p.S98I	DO231607	LINC	ICGC	PRNPLEELR	DEG_APCC_DBOX_1	88:96	Mutation blocking phosphorylation signal	0.7222
p.W79C	DO26479	LUSC	ICGC	PRNPLEELR	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0833
p.I85N	DO220881	MELA	ICGC	PRNPLEELR	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.25
p.P91L	DO222843	MELA	ICGC	PRNPLEELR	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.6471
p.P91L	SIDM01088	Endometrial Carcinoma	GDSC	PRNPLEELR	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.6471
p.P85S	DO50287	SKCM	ICGC	PRNPLEELR	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.25
p.S87F	DO37961	SKCM	ICGC	PRNPLEELR	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.3056
p.A100V	DO47638	SKCM	ICGC	PRNPLEELR	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2222
p.A93V	DO38201	STAD	ICGC	PRNPLEELR	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.6936
p.R587G	DO229204	THCA	ICGC	ESSRQEQLEVPEP	DEG_COP1_1	568:580	Mutation rewiring degron network	0.1389
p.R81C	DO42312	UCEC	ICGC	PRNPLEELR	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1389
p.R81C	DO43907	UCEC	ICGC	PRNPLEELR	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1389
p.I595T	SIDM00353	Other Sarcomas	GDSC	ESSRQEQLEVPEP	DEG_COP1_1	601:613	Mutation rewiring degron network	0.1667
p.I595T	SIDM00526	Chronic Myelogenous Leukemia	GDSC	ESSRQEQLEVPEP	DEG_COP1_1	601:613	Mutation rewiring degron network	0.1667
p.I595T	ACH-000505	Sarcoma	CCLE	ESSRQEQLEVPEP	DEG_COP1_1	601:613	Mutation rewiring degron network	0.1667
p.I595T	MEG-01	haematopoietic and lymphoid tissue	COSMIC	ESSRQEQLEVPEP	DEG_COP1_1	601:613	Mutation rewiring degron network	0.1667
p.I595T	RKN	ovary	COSMIC	ESSRQEQLEVPEP	DEG_COP1_1	601:613	Mutation rewiring degron network	0.1667
p.I599T	SIDM00120	Prostate Carcinoma	GDSC	ESSRQEQLEVPEP	DEG_COP1_1	601:613	Mutation rewiring degron network	0.2778
p.I599T	ACH-000979	Prostate Cancer	CCLE	ESSRQEQLEVPEP	DEG_COP1_1	601:613	Mutation rewiring degron network	0.2778
p.I599T	DU-145	prostate	COSMIC	ESSRQEQLEVPEP	DEG_COP1_1	601:613	Mutation rewiring degron network	0.2778
p.R604P	SIDM00301	Pancreatic Carcinoma	GDSC	ESSRQEQLEVPEP	DEG_COP1_1	601:613	Mutation altering degron motif	0.6401
p.R604P	ACH-000265	Pancreatic Cancer	CCLE	ESSRQEQLEVPEP	DEG_COP1_1	601:613	Mutation altering degron motif	0.6401
p.R604P	KP-4	pancreas	COSMIC	ESSRQEQLEVPEP	DEG_COP1_1	601:613	Mutation altering degron motif	0.6401
p.A584V	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	ESSRQEQLEVPEP	DEG_COP1_1	568:580	Mutation rewiring degron network	0.2222
p.A584V	ACH-000980	Lung Cancer	CCLE	ESSRQEQLEVPEP	DEG_COP1_1	568:580	Mutation rewiring degron network	0.2222
p.A584V	NCI-H1155	lung	COSMIC	ESSRQEQLEVPEP	DEG_COP1_1	568:580	Mutation rewiring degron network	0.2222
p.R571C	SIDM01190	Bladder Carcinoma	GDSC	ESSRQEQLEVPEP	DEG_COP1_1	568:580	Mutation altering degron motif	0.719
p.R571C	ACH-000720	Bladder Cancer	CCLE	ESSRQEQLEVPEP	DEG_COP1_1	568:580	Mutation altering degron motif	0.719
p.R571C	TCCSUP	urinary tract	COSMIC	ESSRQEQLEVPEP	DEG_COP1_1	568:580	Mutation altering degron motif	0.719
p.S529R	SIDM00217	Colorectal Carcinoma	GDSC	SLQEQLEVPEP	DEG_COP1_1	537:547	Mutation rewiring degron network	0.1111
p.S529R	ACH-000999	Colon/Colorectal Cancer	CCLE	SLQEQLEVPEP	DEG_COP1_1	537:547	Mutation rewiring degron network	0.1111
p.S529R	SNU-1040	large intestine	COSMIC	SLQEQLEVPEP	DEG_COP1_1	537:547	Mutation rewiring degron network	0.1111
p.G105E	SIDM00150	Colorectal Carcinoma	GDSC	PRNPLEELR	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0833
p.G105E	ACH-000969	Colon/Colorectal Cancer	CCLE	PRNPLEELR	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0833
p.G105E	KM12	large intestine	COSMIC	PRNPLEELR	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0833
p.R604H	ACH-000854	Myeloma	CCLE	ESSRQEQLEVPEP	DEG_COP1_1	601:613	Mutation altering degron motif	0.7133
p.E590Q	ACH-000889	Myeloma	CCLE	ESSRQEQLEVPEP	DEG_COP1_1	568:580	Mutation rewiring degron network	0.0556
p.P91S	ACH-002396	Bone Cancer	CCLE	PRNPLEELR	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.5641
p.P91S	Sarc9371	bone	COSMIC	PRNPLEELR	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.5641
p.W96S	COLO-320-HSR	large intestine	COSMIC	PRNPLEELR	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.7874

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TROAP

UniProt ID: Q12815

Entrez ID: 10024

Protein name: Tastin (Trophinin-assisting protein) (Trophinin-associated protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TROAP in