DegronMD

Uniprot ID: Q12815

Source protein: Tastin

Source gene: TROAP

Class: DEG_APCC_DBOX_1

Location: 88:96

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9982

ASA_SCORE: 114.5111

COIL: 0.9193

CONS_SCORE: 0.8608

DSS_SCORE: 0.7472

HELIX: 0.0561

FCONS_SCORE: 1.3555

RIG_SCORE: 0.6242

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S86I	TCGA-AN-A0AR	BRCA	TCGA	PRNPLEELR	DEG_APCC_DBOX_1	0.2778
p.S86I	DO4731	BRCA	ICGC	PRNPLEELR	DEG_APCC_DBOX_1	0.2778
p.R89Q	TCGA-AX-A1CE	UCEC	TCGA	PRNPLEELR	DEG_APCC_DBOX_1	0.7329
p.R89Q	DO42280	UCEC	ICGC	PRNPLEELR	DEG_APCC_DBOX_1	0.7329
p.N90H	TCGA-G7-6795	KIRP	TCGA	PRNPLEELR	DEG_APCC_DBOX_1	0.6312
p.N90H	DO20851	KIRP	ICGC	PRNPLEELR	DEG_APCC_DBOX_1	0.6312
p.D91H	DO44033	BLCA	ICGC	PRNPLEELR	DEG_APCC_DBOX_1	0.7688
p.W96C	DO52060	HNSC	ICGC	PRNPLEELR	DEG_APCC_DBOX_1	0.7
p.S98I	DO231607	LINC	ICGC	PRNPLEELR	DEG_APCC_DBOX_1	0.7222
p.W79C	DO26479	LUSC	ICGC	PRNPLEELR	DEG_APCC_DBOX_1	0.0833
p.I85N	DO220881	MELA	ICGC	PRNPLEELR	DEG_APCC_DBOX_1	0.25
p.P91L	DO222843	MELA	ICGC	PRNPLEELR	DEG_APCC_DBOX_1	0.6471
p.P91L	SIDM01088	Endometrial Carcinoma	GDSC	PRNPLEELR	DEG_APCC_DBOX_1	0.6471
p.P85S	DO50287	SKCM	ICGC	PRNPLEELR	DEG_APCC_DBOX_1	0.25
p.S87F	DO37961	SKCM	ICGC	PRNPLEELR	DEG_APCC_DBOX_1	0.3056
p.A100V	DO47638	SKCM	ICGC	PRNPLEELR	DEG_APCC_DBOX_1	0.2222
p.A93V	DO38201	STAD	ICGC	PRNPLEELR	DEG_APCC_DBOX_1	0.6936
p.R81C	DO42312	UCEC	ICGC	PRNPLEELR	DEG_APCC_DBOX_1	0.1389
p.R81C	DO43907	UCEC	ICGC	PRNPLEELR	DEG_APCC_DBOX_1	0.1389
p.G105E	SIDM00150	Colorectal Carcinoma	GDSC	PRNPLEELR	DEG_APCC_DBOX_1	0.0833
p.G105E	ACH-000969	Colon/Colorectal Cancer	CCLE	PRNPLEELR	DEG_APCC_DBOX_1	0.0833
p.G105E	KM12	large_intestine	COSMIC	PRNPLEELR	DEG_APCC_DBOX_1	0.0833
p.P91S	ACH-002396	Bone Cancer	CCLE	PRNPLEELR	DEG_APCC_DBOX_1	0.5641
p.P91S	Sarc9371	bone	COSMIC	PRNPLEELR	DEG_APCC_DBOX_1	0.5641
p.W96S	COLO-320-HSR	large_intestine	COSMIC	PRNPLEELR	DEG_APCC_DBOX_1	0.7874

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12815	Tastin	DEG_APCC_DBOX_1	88:96	PRNPLEELR	APC,CDC20,FZR1	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons