DegronMD

Uniprot ID: Q12815

Source protein: Tastin

Source gene: TROAP

Class: DEG_COP1_1

Location: 568:580

E3 ligase: COP1

DEGRON score: 0.8863

ASA_SCORE: 105.3231

COIL: 0.8462

CONS_SCORE: 0.3532

DSS_SCORE: 0.6746

HELIX: 0.1428

FCONS_SCORE: 0.8574

RIG_SCORE: 0.6109

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E565K	TCGA-13-0794	OV	TCGA	ESSRQEQLEVPEP	DEG_COP1_1	0.25
p.E573G	TCGA-23-1123	OV	TCGA	ESSRQEQLEVPEP	DEG_COP1_1	0.7199
p.V577L	TCGA-60-2714	LUSC	TCGA	ESSRQEQLEVPEP	DEG_COP1_1	0.6765
p.R571H	TCGA-A5-A0G1	UCEC	TCGA	ESSRQEQLEVPEP	DEG_COP1_1	0.7133
p.R571H	TCGA-AJ-A2QO	UCEC	TCGA	ESSRQEQLEVPEP	DEG_COP1_1	0.7133
p.E590K	TCGA-A5-A0G1	UCEC	TCGA	ESSRQEQLEVPEP	DEG_COP1_1	0.0556
p.E590K	DO42472	UCEC	ICGC	ESSRQEQLEVPEP	DEG_COP1_1	0.0556
p.E590K	SIDM00118	Colorectal Carcinoma	GDSC	ESSRQEQLEVPEP	DEG_COP1_1	0.0556
p.E590K	ACH-001081	Colon/Colorectal Cancer	CCLE	ESSRQEQLEVPEP	DEG_COP1_1	0.0556
p.E590K	HCC2998	large_intestine	COSMIC	ESSRQEQLEVPEP	DEG_COP1_1	0.0556
p.E565D	TCGA-BT-A3PJ	BLCA	TCGA	ESSRQEQLEVPEP	DEG_COP1_1	0.25
p.R587G	DO229204	THCA	ICGC	ESSRQEQLEVPEP	DEG_COP1_1	0.1389
p.A584V	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	ESSRQEQLEVPEP	DEG_COP1_1	0.2222
p.A584V	ACH-000980	Lung Cancer	CCLE	ESSRQEQLEVPEP	DEG_COP1_1	0.2222
p.A584V	NCI-H1155	lung	COSMIC	ESSRQEQLEVPEP	DEG_COP1_1	0.2222
p.R571C	SIDM01190	Bladder Carcinoma	GDSC	ESSRQEQLEVPEP	DEG_COP1_1	0.719
p.R571C	ACH-000720	Bladder Cancer	CCLE	ESSRQEQLEVPEP	DEG_COP1_1	0.719
p.R571C	TCCSUP	urinary_tract	COSMIC	ESSRQEQLEVPEP	DEG_COP1_1	0.719
p.E590Q	ACH-000889	Myeloma	CCLE	ESSRQEQLEVPEP	DEG_COP1_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons