DegronMD

Uniprot ID: Q12815

Source protein: Tastin

Source gene: TROAP

Class: DEG_COP1_1

Location: 601:613

E3 ligase: COP1

DEGRON score: 0.6765

ASA_SCORE: 105.8846

COIL: 0.8343

CONS_SCORE: 0.3613

DSS_SCORE: 0.728

HELIX: 0.1526

FCONS_SCORE: 0.6379

RIG_SCORE: 0.6131

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E596K	TCGA-49-6742	LUAD	TCGA	ESSRQEQLEVPEP	DEG_COP1_1	0.1944
p.E596K	DO25622	LUAD	ICGC	ESSRQEQLEVPEP	DEG_COP1_1	0.1944
p.P619L	TCGA-AP-A1DV	UCEC	TCGA	ESSRQEQLEVPEP	DEG_COP1_1	0.1667
p.S591P	TCGA-AZ-6601	COAD	TCGA	ESSRQEQLEVPEP	DEG_COP1_1	0.0556
p.S591P	DO8119	COAD	ICGC	ESSRQEQLEVPEP	DEG_COP1_1	0.0556
p.P619H	TCGA-BR-8081	STAD	TCGA	ESSRQEQLEVPEP	DEG_COP1_1	0.1667
p.R594M	TCGA-EE-A2MG	SKCM	TCGA	ESSRQEQLEVPEP	DEG_COP1_1	0.1389
p.R594M	DO37421	SKCM	ICGC	ESSRQEQLEVPEP	DEG_COP1_1	0.1389
p.P597H	TCGA-HU-A4GU	STAD	TCGA	ESSRQEQLEVPEP	DEG_COP1_1	0.2222
p.P597H	DO47849	STAD	ICGC	ESSRQEQLEVPEP	DEG_COP1_1	0.2222
p.E596A	DO233885	GACA	ICGC	ESSRQEQLEVPEP	DEG_COP1_1	0.1944
p.I595S	DO228902	LICA	ICGC	ESSRQEQLEVPEP	DEG_COP1_1	0.1667
p.I595S	DO230529	LUSC	ICGC	ESSRQEQLEVPEP	DEG_COP1_1	0.1667
p.I595S	DO231176	LUSC	ICGC	ESSRQEQLEVPEP	DEG_COP1_1	0.1667
p.I595S	ACH-000352	Breast Cancer	CCLE	ESSRQEQLEVPEP	DEG_COP1_1	0.1667
p.Y592C	DO228902	LICA	ICGC	ESSRQEQLEVPEP	DEG_COP1_1	0.0833
p.Y592C	DO229055	LICA	ICGC	ESSRQEQLEVPEP	DEG_COP1_1	0.0833
p.I595T	SIDM00353	Other Sarcomas	GDSC	ESSRQEQLEVPEP	DEG_COP1_1	0.1667
p.I595T	SIDM00526	Chronic Myelogenous Leukemia	GDSC	ESSRQEQLEVPEP	DEG_COP1_1	0.1667
p.I595T	ACH-000505	Sarcoma	CCLE	ESSRQEQLEVPEP	DEG_COP1_1	0.1667
p.I595T	MEG-01	haematopoietic_and_lymphoid_tissue	COSMIC	ESSRQEQLEVPEP	DEG_COP1_1	0.1667
p.I595T	RKN	ovary	COSMIC	ESSRQEQLEVPEP	DEG_COP1_1	0.1667
p.I599T	SIDM00120	Prostate Carcinoma	GDSC	ESSRQEQLEVPEP	DEG_COP1_1	0.2778
p.I599T	ACH-000979	Prostate Cancer	CCLE	ESSRQEQLEVPEP	DEG_COP1_1	0.2778
p.I599T	DU-145	prostate	COSMIC	ESSRQEQLEVPEP	DEG_COP1_1	0.2778
p.R604P	SIDM00301	Pancreatic Carcinoma	GDSC	ESSRQEQLEVPEP	DEG_COP1_1	0.6401
p.R604P	ACH-000265	Pancreatic Cancer	CCLE	ESSRQEQLEVPEP	DEG_COP1_1	0.6401
p.R604P	KP-4	pancreas	COSMIC	ESSRQEQLEVPEP	DEG_COP1_1	0.6401
p.R604H	ACH-000854	Myeloma	CCLE	ESSRQEQLEVPEP	DEG_COP1_1	0.7133

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ESSRQEQLEVPEP

Degron related mutations and impact score

Drug responses associated with TROAP mutations

All proteins holding degron of ESSRQEQLEVPEP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12815	Tastin	DEG_COP1_1	568:580	ESSRQEQLEVPEP	COP1	0.8863	More...
Q12815	Tastin	DEG_COP1_1	601:613	ESSRQEQLEVPEP	COP1	0.6765	More...