DegronMD

Uniprot ID: Q12815

Source protein: Tastin

Source gene: TROAP

Class: DEG_COP1_1

Location: 537:547

E3 ligase: COP1

DEGRON score: 0.7164

ASA_SCORE: 97.8364

COIL: 0.7807

CONS_SCORE: 0.2268

DSS_SCORE: 0.775

HELIX: 0.2085

FCONS_SCORE: 1.0098

RIG_SCORE: 0.6323

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E546D	TCGA-49-6767	LUAD	TCGA	SLQEQLEVPEP	DEG_COP1_1	0.5647
p.P549H	TCGA-AA-3715	COAD	TCGA	SLQEQLEVPEP	DEG_COP1_1	0.2778
p.Q539E	TCGA-ER-A19G	SKCM	TCGA	SLQEQLEVPEP	DEG_COP1_1	0.5633
p.E532D	TCGA-YD-A9TA	SKCM	TCGA	SLQEQLEVPEP	DEG_COP1_1	0.1944
p.S529R	SIDM00217	Colorectal Carcinoma	GDSC	SLQEQLEVPEP	DEG_COP1_1	0.1111
p.S529R	ACH-000999	Colon/Colorectal Cancer	CCLE	SLQEQLEVPEP	DEG_COP1_1	0.1111
p.S529R	SNU-1040	large_intestine	COSMIC	SLQEQLEVPEP	DEG_COP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12815	Tastin	DEG_COP1_1	537:547	SLQEQLEVPEP	COP1	0.7164	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons