DegronMD

Uniprot ID: Q99816

Source protein: Tumor susceptibility gene 101 protein

Source gene: TSG101

Class: DEG_SPOP_SBC_1

Location: 197:201

E3 ligase: SPOP

DEGRON score: 0.9804

ASA_SCORE: 70.14

COIL: 0.8988

CONS_SCORE: 0.4175

DSS_SCORE: 0.6304

HELIX: 0.0432

FCONS_SCORE: 0.9833

RIG_SCORE: 0.6185

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P189S	TCGA-AA-3989	COAD	TCGA	PATTS	DEG_SPOP_SBC_1	0.1111
p.P189S	DO9666	COAD	ICGC	PATTS	DEG_SPOP_SBC_1	0.1111
p.S202Y	TCGA-ND-A4WC	UCS	TCGA	PATTS	DEG_SPOP_SBC_1	0.3056
p.S202F	DO8264	COAD	ICGC	PATTS	DEG_SPOP_SBC_1	0.3056
p.G187D	DO228608	LICA	ICGC	PATTS	DEG_SPOP_SBC_1	0.0556
p.P208H	DO228974	LICA	ICGC	PATTS	DEG_SPOP_SBC_1	0.1389
p.P197T	DO229019	LICA	ICGC	PATTS	DEG_SPOP_SBC_1	0.7031
p.P208T	DO229027	LICA	ICGC	PATTS	DEG_SPOP_SBC_1	0.1389
p.G194S	DO45149	LIRI	ICGC	PATTS	DEG_SPOP_SBC_1	0.25
p.Y190S	DO218888	SKCA	ICGC	PATTS	DEG_SPOP_SBC_1	0.1389
p.Y190S	DO227681	SKCA	ICGC	PATTS	DEG_SPOP_SBC_1	0.1389
p.P208L	SIDM00510	Small Cell Lung Carcinoma	GDSC	PATTS	DEG_SPOP_SBC_1	0.1389
p.P208L	ACH-002095	Lung Cancer	CCLE	PATTS	DEG_SPOP_SBC_1	0.1389
p.P208L	COR-L303	lung	COSMIC	PATTS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00562	Membrane-associated phosphatidylinositol transfer protein 1	DEG_SPOP_SBC_1	652:656	PATTS	SPOP	0.8499	More...
P08651	Nuclear factor 1 C-type	DEG_SPOP_SBC_1	460:464	PATTS	SPOP	0.9973	More...
P18146	Early growth response protein 1	DEG_SPOP_SBC_1	461:465	PATTS	SPOP	0.9422	More...
P34810	Macrosialin	DEG_SPOP_SBC_1	111:115	PATTS	SPOP	0.9679	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	151:155	PATTS	SPOP	0.9788	More...
Q00535	Cyclin-dependent kinase 5	DEG_SPOP_SBC_1	243:247	PATTS	SPOP	0.9123	More...
Q12815	Tastin	DEG_SPOP_SBC_1	667:671	PATTS	SPOP	0.6469	More...
Q13585	Melatonin-related receptor	DEG_SPOP_SBC_1	523:527	PATTS	SPOP	0.9934	More...
Q2UY09	Collagen alpha-1	DEG_SPOP_SBC_1	1045:1049	PATTS	SPOP	0.9604	More...
Q68D85	Natural cytotoxicity triggering receptor 3 ligand 1	DEG_SPOP_SBC_1	433:437	PATTS	SPOP	0.9972	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7103:7107	PATTS	SPOP	0.9088	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7978:7982	PATTS	SPOP	0.8819	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8273:8277	PATTS	SPOP	0.9418	More...
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	DEG_SPOP_SBC_1	169:173	PATTS	SPOP	0.9946	More...
Q99816	Tumor susceptibility gene 101 protein	DEG_SPOP_SBC_1	197:201	PATTS	SPOP	0.9804	More...
Q9BVL2	Nucleoporin p58/p45	DEG_SPOP_SBC_1	98:102	PATTS	SPOP	0.8588	More...
Q9Y6R0	Numb-like protein	DEG_SPOP_SBC_1	266:270	PATTS	SPOP	0.9987	More...
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SPOP_SBC_1	1751:1755	PATTS	SPOP	0.9429	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons