DegronMD - Q2UY09(COL28A1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P703S	TCGA-3N-A9WC	SKCM	TCGA	PPGY	ITCH	703:706	Mutation altering degron motif	0.6752
p.P703S	DO51234	SKCM	ICGC	PPGY	ITCH	703:706	Mutation altering degron motif	0.6752
p.W1040L	TCGA-BF-A1PZ	SKCM	TCGA	PATTS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.1944
p.W1040L	DO50279	SKCM	ICGC	PATTS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.1944
p.T1048P	TCGA-CN-4727	HNSC	TCGA	PATTS	DEG_SPOP_SBC_1	1045:1049	Mutation altering degron motif	0.7031
p.T1048P	DO14258	HNSC	ICGC	PATTS	DEG_SPOP_SBC_1	1045:1049	Mutation altering degron motif	0.7031
p.E714K	TCGA-D3-A2JP	SKCM	TCGA	PPGY	ITCH	703:706	Mutation rewiring degron network	0.1111
p.E714K	DO47407	SKCM	ICGC	PPGY	ITCH	703:706	Mutation rewiring degron network	0.1111
p.G716E	TCGA-FI-A2EX	UCEC	TCGA	PPGY	ITCH	703:706	Mutation rewiring degron network	0.0556
p.G716E	DO42352	UCEC	ICGC	PPGY	ITCH	703:706	Mutation rewiring degron network	0.0556
p.G710E	TCGA-FS-A1ZK	SKCM	TCGA	PPGY	ITCH	703:706	Mutation rewiring degron network	0.2222
p.G710E	DO37474	SKCM	ICGC	PPGY	ITCH	703:706	Mutation rewiring degron network	0.2222
p.S708L	TCGA-FS-A1ZZ	SKCM	TCGA	PPGY	ITCH	703:706	Mutation rewiring degron network	0.2778
p.S708L	DO37412	SKCM	ICGC	PPGY	ITCH	703:706	Mutation rewiring degron network	0.2778
p.A1035S	DO220554	KICH	ICGC	PATTS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.0556
p.A1046D	DO228974	LICA	ICGC	PATTS	DEG_SPOP_SBC_1	1045:1049	Mutation altering degron motif	0.6682
p.T1053N	DO229026	LICA	ICGC	PATTS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.2222
p.G713E	DO220885	MELA	ICGC	PPGY	ITCH	703:706	Mutation rewiring degron network	0.1389
p.D1043V	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	PATTS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.2778
p.D1043V	ACH-002264	Esophageal Cancer	CCLE	PATTS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.2778
p.D1043V	KYSE-50	oesophagus	COSMIC	PATTS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.2778
p.D1043N	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	PATTS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.2778
p.D1043N	ACH-002264	Esophageal Cancer	CCLE	PATTS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.2778
p.D1043N	KYSE-50	oesophagus	COSMIC	PATTS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.2778
p.T1039K	SIDM01409	Bladder Carcinoma	GDSC	PATTS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.1667
p.T1039K	ACH-000834	Bladder Cancer	CCLE	PATTS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.1667
p.G702A	NCI-H630	large intestine	COSMIC	PPGY	ITCH	703:706	Mutation rewiring degron network	0.3056

Kaplan plot for COL28A1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COL28A1

UniProt ID: Q2UY09

Entrez ID: 340267

Protein name: Collagen alpha-1(XXVIII) chain

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for COL28A1 in