DegronMD - Q68D85(NCR3LG1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K404T	TCGA-BK-A6W3	UCEC	TCGA	EHSDAVPDA	DEG_COP1_1	412:420	Mutation substituting flanking lysine	0.2222
p.K404T	DO50076	UCEC	ICGC	EHSDAVPDA	DEG_COP1_1	412:420	Mutation substituting flanking lysine	0.2222
p.P418L	TCGA-C8-A8HQ	BRCA	TCGA	EHSDAVPDA	DEG_COP1_1	412:420	Mutation altering degron motif	0.7582
p.P418L	TCGA-FI-A2D0	UCEC	TCGA	EHSDAVPDA	DEG_COP1_1	412:420	Mutation altering degron motif	0.7582
p.P418L	DO219623	BRCA	ICGC	EHSDAVPDA	DEG_COP1_1	412:420	Mutation altering degron motif	0.7582
p.P418L	DO43891	UCEC	ICGC	EHSDAVPDA	DEG_COP1_1	412:420	Mutation altering degron motif	0.7582
p.P143L	DO228998	LICA	ICGC	SRLLLDQVG	DEG_APCC_DBOX_1	145:153	Mutation rewiring degron network	0.2778
p.P447L	DO229054	LICA	ICGC	PATTS	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.0556
p.P433A	DO228349	MALY	ICGC	PATTS	DEG_SPOP_SBC_1	433:437	Mutation altering degron motif	0.6392
p.P433A	SIDM00656	Burkitt's Lymphoma	GDSC	PATTS	DEG_SPOP_SBC_1	433:437	Mutation altering degron motif	0.6392
p.P433A	ACH-000944	Lymphoma	CCLE	PATTS	DEG_SPOP_SBC_1	433:437	Mutation altering degron motif	0.6392
p.P433A	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	PATTS	DEG_SPOP_SBC_1	433:437	Mutation altering degron motif	0.6392
p.RE411RK	DO222632	MELA	ICGC	EHSDAVPDA	DEG_COP1_1	412:420	Mutation rewiring degron network	0
p.P433L	DO229446	SKCA	ICGC	PATTS	DEG_SPOP_SBC_1	433:437	Mutation altering degron motif	0.7582
p.I422V	SIDM00878	Breast Carcinoma	GDSC	EHSDAVPDA	DEG_COP1_1	412:420	Mutation rewiring degron network	0.2778
p.I422V	ACH-000930	Breast Cancer	CCLE	EHSDAVPDA	DEG_COP1_1	412:420	Mutation rewiring degron network	0.2778
p.I422V	HCC1569	breast	COSMIC	EHSDAVPDA	DEG_COP1_1	412:420	Mutation rewiring degron network	0.2778
p.S414L	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	EHSDAVPDA	DEG_COP1_1	412:420	Mutation altering degron motif	0.7667
p.P440L	SIDM00003	Melanoma	GDSC	PATTS	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.25
p.P440L	ACH-000884	Skin Cancer	CCLE	PATTS	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.25
p.P440L	ACH-002159	Skin Cancer	CCLE	PATTS	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.25
p.P440L	M14	skin	COSMIC	PATTS	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.25
p.P410H	SIDM00946	T-Lymphoblastic Leukemia	GDSC	EHSDAVPDA	DEG_COP1_1	412:420	Mutation rewiring degron network	0.2778
p.P410H	ACH-000981	Leukemia	CCLE	EHSDAVPDA	DEG_COP1_1	412:420	Mutation rewiring degron network	0.2778
p.P410H	DND-41	haematopoietic and lymphoid tissue	COSMIC	EHSDAVPDA	DEG_COP1_1	412:420	Mutation rewiring degron network	0.2778
p.T436A	ACH-001031	Rhabdoid	CCLE	PATTS	DEG_SPOP_SBC_1	433:437	Mutation altering degron motif	0.7139
p.L442P	ACH-001407	Bladder Cancer	CCLE	PATTS	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.1944

Kaplan plot for NCR3LG1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NCR3LG1

UniProt ID: Q68D85

Entrez ID: 374383

Protein name: Natural cytotoxicity triggering receptor 3 ligand 1 (B7 homolog 6) (B7-H6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NCR3LG1 in