DegronMD

Uniprot ID: Q68D85

Source protein: Natural cytotoxicity triggering receptor 3 ligand 1

Source gene: NCR3LG1

Class: DEG_COP1_1

Location: 412:420

E3 ligase: COP1

DEGRON score: 0.9433

ASA_SCORE: 91.8667

COIL: 0.92

CONS_SCORE: 0.2948

DSS_SCORE: 0.692

HELIX: 0.0621

FCONS_SCORE: 0.8406

RIG_SCORE: 0.6545

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K404T	TCGA-BK-A6W3	UCEC	TCGA	EHSDAVPDA	DEG_COP1_1	0.2222
p.K404T	DO50076	UCEC	ICGC	EHSDAVPDA	DEG_COP1_1	0.2222
p.P418L	TCGA-C8-A8HQ	BRCA	TCGA	EHSDAVPDA	DEG_COP1_1	0.7582
p.P418L	TCGA-FI-A2D0	UCEC	TCGA	EHSDAVPDA	DEG_COP1_1	0.7582
p.P418L	DO219623	BRCA	ICGC	EHSDAVPDA	DEG_COP1_1	0.7582
p.P418L	DO43891	UCEC	ICGC	EHSDAVPDA	DEG_COP1_1	0.7582
p.RE411RK	DO222632	MELA	ICGC	EHSDAVPDA	DEG_COP1_1	0
p.I422V	SIDM00878	Breast Carcinoma	GDSC	EHSDAVPDA	DEG_COP1_1	0.2778
p.I422V	ACH-000930	Breast Cancer	CCLE	EHSDAVPDA	DEG_COP1_1	0.2778
p.I422V	HCC1569	breast	COSMIC	EHSDAVPDA	DEG_COP1_1	0.2778
p.S414L	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	EHSDAVPDA	DEG_COP1_1	0.7667
p.P410H	SIDM00946	T-Lymphoblastic Leukemia	GDSC	EHSDAVPDA	DEG_COP1_1	0.2778
p.P410H	ACH-000981	Leukemia	CCLE	EHSDAVPDA	DEG_COP1_1	0.2778
p.P410H	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	EHSDAVPDA	DEG_COP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68D85	Natural cytotoxicity triggering receptor 3 ligand 1	DEG_COP1_1	412:420	EHSDAVPDA	COP1	0.9433	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons