DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
SRLLLDQVG
Uniprot ID:
Q68D85
Source protein:
Natural cytotoxicity triggering receptor 3 ligand 1
Source gene:
NCR3LG1
Class:
DEG_APCC_DBOX_1
Location:
145:153
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6942
ASA_SCORE:
75.8556
COIL:
0.5329
CONS_SCORE:
0.2713
DSS_SCORE:
0.2862
HELIX:
0.0497
FCONS_SCORE:
0.589
RIG_SCORE:
0.8214
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P143L
DO228998
LICA
ICGC
SRLLLDQVG
DEG_APCC_DBOX_1
0.2778
Drug responses associated with NCR3LG1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SRLLLDQVG
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q68D85
Natural cytotoxicity triggering receptor 3 ligand 1
DEG_APCC_DBOX_1
145:153
SRLLLDQVG
APC,CDC20,FZR1
0.6942
More...