DegronMD

Uniprot ID: P18146

Source protein: Early growth response protein 1

Source gene: EGR1

Class: DEG_SCF_FBW7_1

Location: 284:291

E3 ligase: FBXW7

DEGRON score: 0.9901

ASA_SCORE: 69.9

COIL: 0.7993

CONS_SCORE: 0.4344

DSS_SCORE: 0.5396

HELIX: 0.0986

FCONS_SCORE: 1.0943

RIG_SCORE: 0.7189

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G276S	TCGA-17-Z005	LUAD	TCGA	PSLTPLST	DEG_SCF_FBW7_1	0.1111
p.A294D	TCGA-27-2527	GBM	TCGA	PSLTPLST	DEG_SCF_FBW7_1	0.25
p.A294D	DO12298	GBM	ICGC	PSLTPLST	DEG_SCF_FBW7_1	0.25
p.R280H	TCGA-D1-A167	UCEC	TCGA	PSLTPLST	DEG_SCF_FBW7_1	0.2222
p.R280H	TCGA-XF-A8HG	BLCA	TCGA	PSLTPLST	DEG_SCF_FBW7_1	0.2222
p.R280H	DO49802	BLCA	ICGC	PSLTPLST	DEG_SCF_FBW7_1	0.2222
p.R280H	DO40978	UCEC	ICGC	PSLTPLST	DEG_SCF_FBW7_1	0.2222
p.A294V	TCGA-DU-6392	LGG	TCGA	PSLTPLST	DEG_SCF_FBW7_1	0.25
p.A294V	DO22237	LGG	ICGC	PSLTPLST	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18146	Early growth response protein 1	DEG_SCF_FBW7_1	284:291	PSLTPLST	FBXW7	0.9901	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons