DegronMD

Uniprot ID: P18146

Source protein: Early growth response protein 1

Source gene: EGR1

Class: DEG_SCF_FBW7_2

Location: 328:335

E3 ligase: FBXW7

DEGRON score: 0.9243

ASA_SCORE: 81.725

COIL: 0.8545

CONS_SCORE: 0.707

DSS_SCORE: 0.66

HELIX: 0.006

FCONS_SCORE: 1.0684

RIG_SCORE: 0.5566

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R320H	TCGA-10-0930	OV	TCGA	PSKTPPHE	DEG_SCF_FBW7_2	0.1111
p.R320H	DO32113	OV	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	0.1111
p.R320H	SIDM01619	Endometrial Carcinoma	GDSC	PSKTPPHE	DEG_SCF_FBW7_2	0.1111
p.R320H	ACH-000984	Endometrial/Uterine Cancer	CCLE	PSKTPPHE	DEG_SCF_FBW7_2	0.1111
p.T331M	TCGA-32-2615	GBM	TCGA	PSKTPPHE	DEG_SCF_FBW7_2	0.7423
p.T331M	TCGA-A5-A0G1	UCEC	TCGA	PSKTPPHE	DEG_SCF_FBW7_2	0.7423
p.T331M	TCGA-A6-6780	COAD	TCGA	PSKTPPHE	DEG_SCF_FBW7_2	0.7423
p.T331M	DO10244	COAD	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	0.7423
p.T331M	DO11172	GBM	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	0.7423
p.T331M	DO42472	UCEC	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	0.7423
p.R322C	TCGA-AA-3663	COAD	TCGA	PSKTPPHE	DEG_SCF_FBW7_2	0.1667
p.R322C	TCGA-CG-4306	STAD	TCGA	PSKTPPHE	DEG_SCF_FBW7_2	0.1667
p.R322C	TCGA-VQ-A8PB	STAD	TCGA	PSKTPPHE	DEG_SCF_FBW7_2	0.1667
p.R322C	DO9346	COAD	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	0.1667
p.R322C	DO8858	COAD	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	0.1667
p.R322C	DO38567	STAD	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	0.1667
p.R322C	DO51766	STAD	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	0.1667
p.R336C	TCGA-AJ-A3BH	UCEC	TCGA	PSKTPPHE	DEG_SCF_FBW7_2	0.3056
p.R336C	DO41638	UCEC	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	0.3056
p.R336C	SIDM00799	Glioblastoma	GDSC	PSKTPPHE	DEG_SCF_FBW7_2	0.3056
p.R336C	ACH-000558	Brain Cancer	CCLE	PSKTPPHE	DEG_SCF_FBW7_2	0.3056
p.R336C	A172	central_nervous_system	COSMIC	PSKTPPHE	DEG_SCF_FBW7_2	0.3056
p.E335K	TCGA-AP-A0LM	UCEC	TCGA	PSKTPPHE	DEG_SCF_FBW7_2	0.7022
p.E335K	TCGA-E6-A1LX	UCEC	TCGA	PSKTPPHE	DEG_SCF_FBW7_2	0.7022
p.E335K	DO8730	COAD	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	0.7022
p.E335K	DO43306	UCEC	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	0.7022
p.E335K	DO41020	UCEC	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	0.7022
p.R327Q	TCGA-HQ-A2OF	BLCA	TCGA	PSKTPPHE	DEG_SCF_FBW7_2	0.3056
p.R327Q	DO51898	BLCA	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	0.3056
p.R327Q	SIDM00217	Colorectal Carcinoma	GDSC	PSKTPPHE	DEG_SCF_FBW7_2	0.3056
p.R327Q	ACH-000999	Colon/Colorectal Cancer	CCLE	PSKTPPHE	DEG_SCF_FBW7_2	0.3056
p.A339T	TCGA-XK-AAIW	PRAD	TCGA	PSKTPPHE	DEG_SCF_FBW7_2	0.2222
p.A339T	DO51407	PRAD	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	0.2222
p.R322H	DO229389	BTCA	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	0.1667
p.R322H	DO233737	GACA	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	0.1667
p.R336L	DO229009	LICA	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	0.3056
p.P333R	DO50847	LICA	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	0.6401
p.A339G	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PSKTPPHE	DEG_SCF_FBW7_2	0.2222
p.A339G	ACH-001127	Leukemia	CCLE	PSKTPPHE	DEG_SCF_FBW7_2	0.2222
p.A339G	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PSKTPPHE	DEG_SCF_FBW7_2	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSKTPPHE

Degron related mutations and impact score

Drug responses associated with EGR1 mutations

All proteins holding degron of PSKTPPHE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18146	Early growth response protein 1	DEG_SCF_FBW7_2	328:335	PSKTPPHE	FBXW7	0.9243	More...