DegronMD - Q86UW9(DTX2)

DTX2

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L287M	TCGA-OL-A97C	BRCA	TCGA	YRSSLSHLG	DEG_APCC_DBOX_1	280:288	Mutation altering degron motif	0.5999
p.L287M	DO219640	BRCA	ICGC	YRSSLSHLG	DEG_APCC_DBOX_1	280:288	Mutation altering degron motif	0.5999
p.S285F	TCGA-QC-A7B5	SARC	TCGA	YRSSLSHLG	DEG_APCC_DBOX_1	280:288	Mutation altering degron motif	0.6871
p.S285F	DO220239	SARC	ICGC	YRSSLSHLG	DEG_APCC_DBOX_1	280:288	Mutation altering degron motif	0.6871
p.L279I	SIDM00451	T-Lymphoblastic Leukemia	GDSC	YRSSLSHLG	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.3056
p.L279I	ACH-000937	Leukemia	CCLE	YRSSLSHLG	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.3056
p.L279I	PF-382	haematopoietic and lymphoid tissue	COSMIC	YRSSLSHLG	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.3056
p.S305P	ACH-001345	Colon/Colorectal Cancer	CCLE	PGSST	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1389
p.S305P	GP5d	large intestine	COSMIC	PGSST	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc