DegronMD

Uniprot ID: Q86UW9

Source protein: Probable E3 ubiquitin-protein ligase DTX2

Source gene: DTX2

Class: DEG_APCC_DBOX_1

Location: 280:288

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9985

ASA_SCORE: 80.4778

COIL: 0.7547

CONS_SCORE: 0.3059

DSS_SCORE: 0.5956

HELIX: 0.1441

FCONS_SCORE: 1.0779

RIG_SCORE: 0.6294

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L287M	TCGA-OL-A97C	BRCA	TCGA	YRSSLSHLG	DEG_APCC_DBOX_1	0.5999
p.L287M	DO219640	BRCA	ICGC	YRSSLSHLG	DEG_APCC_DBOX_1	0.5999
p.S285F	TCGA-QC-A7B5	SARC	TCGA	YRSSLSHLG	DEG_APCC_DBOX_1	0.6871
p.S285F	DO220239	SARC	ICGC	YRSSLSHLG	DEG_APCC_DBOX_1	0.6871
p.L279I	SIDM00451	T-Lymphoblastic Leukemia	GDSC	YRSSLSHLG	DEG_APCC_DBOX_1	0.3056
p.L279I	ACH-000937	Leukemia	CCLE	YRSSLSHLG	DEG_APCC_DBOX_1	0.3056
p.L279I	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	YRSSLSHLG	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UW9	Probable E3 ubiquitin-protein ligase DTX2	DEG_APCC_DBOX_1	280:288	YRSSLSHLG	APC,CDC20,FZR1	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons