DegronMD - Q9ULL5(PRR12)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K692Q	TCGA-2Z-A9JO	KIRP	TCGA	QRYHLQSVI	DEG_APCC_DBOX_1	696:704	Mutation substituting flanking lysine	0.3333
p.K692Q	DO219681	KIRP	ICGC	QRYHLQSVI	DEG_APCC_DBOX_1	696:704	Mutation substituting flanking lysine	0.3333
p.Y688C	TCGA-56-6546	LUSC	TCGA	QRYHLQSVI	DEG_APCC_DBOX_1	696:704	Mutation rewiring degron network	0.1111
p.Y688C	DO26542	LUSC	ICGC	QRYHLQSVI	DEG_APCC_DBOX_1	696:704	Mutation rewiring degron network	0.1111
p.R1120H	TCGA-A5-A1OF	UCEC	TCGA	SRPALSPLG	DEG_APCC_DBOX_1	1130:1138	Mutation rewiring degron network	0.0556
p.R1120H	DO42568	UCEC	ICGC	SRPALSPLG	DEG_APCC_DBOX_1	1130:1138	Mutation rewiring degron network	0.0556
p.A978T	TCGA-AA-3655	COAD	TCGA	PPAY	ITCH	984:987	Mutation rewiring degron network	0.1667
p.A978T	DO10180	COAD	ICGC	PPAY	ITCH	984:987	Mutation rewiring degron network	0.1667
p.R1131C	TCGA-AA-A01R	COAD	TCGA	SRPALSPLG	DEG_APCC_DBOX_1	1130:1138	Mutation altering degron motif	0.8301
p.R1131C	DO7934	COAD	ICGC	SRPALSPLG	DEG_APCC_DBOX_1	1130:1138	Mutation altering degron motif	0.8301
p.R1294C	TCGA-AH-6644	READ	TCGA	LTPPLS	DEG_SCF_FBW7_1	1303:1308	Mutation rewiring degron network	0.0833
p.R1294C	TCGA-AH-6644	READ	TCGA	PPLY	ITCH	1296:1299	Mutation rewiring degron network	0.2778
p.R1294C	DO37237	READ	ICGC	LTPPLS	DEG_SCF_FBW7_1	1303:1308	Mutation rewiring degron network	0.0833
p.R1294C	DO37237	READ	ICGC	PPLY	ITCH	1296:1299	Mutation rewiring degron network	0.2778
p.K1708R	TCGA-AP-A1DP	UCEC	TCGA	PETPEKT	DEG_SCF_FBW7_1	1703:1709	Mutation altering degron motif	0.6126
p.K1708R	DO42336	UCEC	ICGC	PETPEKT	DEG_SCF_FBW7_1	1703:1709	Mutation altering degron motif	0.6126
p.T1304M	TCGA-AX-A1CE	UCEC	TCGA	LTPPLS	DEG_SCF_FBW7_1	1303:1308	Mutation altering degron motif	0.8534
p.T1304M	DO27128	LUSC	ICGC	LTPPLS	DEG_SCF_FBW7_1	1303:1308	Mutation altering degron motif	0.8534
p.T1304M	DO42280	UCEC	ICGC	LTPPLS	DEG_SCF_FBW7_1	1303:1308	Mutation altering degron motif	0.8534
p.S133L	TCGA-AX-A2HC	UCEC	TCGA	MHTPGPT	DEG_SCF_FBW7_1	122:128	Mutation rewiring degron network	0.1944
p.S133L	TCGA-AX-A2HC	UCEC	TCGA	PGSST	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.2222
p.S133L	DO41572	UCEC	ICGC	MHTPGPT	DEG_SCF_FBW7_1	122:128	Mutation rewiring degron network	0.1944
p.S133L	DO41572	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.2222
p.T124M	TCGA-AZ-6601	COAD	TCGA	MHTPGPT	DEG_SCF_FBW7_1	122:128	Mutation altering degron motif	0.7423
p.T124M	DO8119	COAD	ICGC	MHTPGPT	DEG_SCF_FBW7_1	122:128	Mutation altering degron motif	0.7423
p.S1127C	TCGA-BC-A3KF	LIHC	TCGA	SRPALSPLG	DEG_APCC_DBOX_1	1130:1138	Mutation rewiring degron network	0.25
p.S1127C	DO22990	LIHC	ICGC	SRPALSPLG	DEG_APCC_DBOX_1	1130:1138	Mutation rewiring degron network	0.25
p.P1306L	TCGA-BC-A69H	LIHC	TCGA	LTPPLS	DEG_SCF_FBW7_1	1303:1308	Mutation altering degron motif	0.6471
p.P1306L	DO44927	LIHC	ICGC	LTPPLS	DEG_SCF_FBW7_1	1303:1308	Mutation altering degron motif	0.6471
p.A691P	TCGA-BH-A1FN	BRCA	TCGA	QRYHLQSVI	DEG_APCC_DBOX_1	696:704	Mutation rewiring degron network	0.1944
p.A691P	DO5214	BRCA	ICGC	QRYHLQSVI	DEG_APCC_DBOX_1	696:704	Mutation rewiring degron network	0.1944
p.E712K	TCGA-BT-A0YX	BLCA	TCGA	QRYHLQSVI	DEG_APCC_DBOX_1	696:704	Mutation rewiring degron network	0.1111
p.E712K	DO516	BLCA	ICGC	QRYHLQSVI	DEG_APCC_DBOX_1	696:704	Mutation rewiring degron network	0.1111
p.S1820P	TCGA-CM-5861	COAD	TCGA	PGSSS	DEG_SPOP_SBC_1	1816:1820	Mutation altering degron motif	0.6752
p.S1820P	DO7918	COAD	ICGC	PGSSS	DEG_SPOP_SBC_1	1816:1820	Mutation altering degron motif	0.6752
p.S702C	TCGA-CR-7369	HNSC	TCGA	QRYHLQSVI	DEG_APCC_DBOX_1	696:704	Mutation altering degron motif	0.643
p.S702C	DO14934	HNSC	ICGC	QRYHLQSVI	DEG_APCC_DBOX_1	696:704	Mutation altering degron motif	0.643
p.R1294H	TCGA-D5-6540	COAD	TCGA	LTPPLS	DEG_SCF_FBW7_1	1303:1308	Mutation rewiring degron network	0.0833
p.R1294H	TCGA-D5-6540	COAD	TCGA	PPLY	ITCH	1296:1299	Mutation rewiring degron network	0.2778
p.R1294H	DO9708	COAD	ICGC	LTPPLS	DEG_SCF_FBW7_1	1303:1308	Mutation rewiring degron network	0.0833
p.R1294H	DO9708	COAD	ICGC	PPLY	ITCH	1296:1299	Mutation rewiring degron network	0.2778
p.G134S	TCGA-DF-A2KN	UCEC	TCGA	MHTPGPT	DEG_SCF_FBW7_1	122:128	Mutation rewiring degron network	0.1667
p.G134S	TCGA-DF-A2KN	UCEC	TCGA	PGSST	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.25
p.G134S	DO223282	UCEC	ICGC	MHTPGPT	DEG_SCF_FBW7_1	122:128	Mutation rewiring degron network	0.1667
p.G134S	DO223282	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.25
p.V703A	TCGA-FS-A4F5	SKCM	TCGA	QRYHLQSVI	DEG_APCC_DBOX_1	696:704	Mutation altering degron motif	0.6936
p.V703A	DO37881	SKCM	ICGC	QRYHLQSVI	DEG_APCC_DBOX_1	696:704	Mutation altering degron motif	0.6936
p.T120A	TCGA-FY-A4B3	THCA	TCGA	MHTPGPT	DEG_SCF_FBW7_1	122:128	Mutation rewiring degron network	0.2778
p.T120A	DO48072	THCA	ICGC	MHTPGPT	DEG_SCF_FBW7_1	122:128	Mutation rewiring degron network	0.2778
p.Q696K	TCGA-HE-7129	KIRP	TCGA	QRYHLQSVI	DEG_APCC_DBOX_1	696:704	Mutation altering degron motif	0.5833
p.Q696K	DO20786	KIRP	ICGC	QRYHLQSVI	DEG_APCC_DBOX_1	696:704	Mutation altering degron motif	0.5833
p.P1306A	TCGA-HQ-A5NE	BLCA	TCGA	LTPPLS	DEG_SCF_FBW7_1	1303:1308	Mutation altering degron motif	0.6392
p.P1306A	DO51900	BLCA	ICGC	LTPPLS	DEG_SCF_FBW7_1	1303:1308	Mutation altering degron motif	0.6392
p.R705C	TCGA-HU-A4H3	STAD	TCGA	QRYHLQSVI	DEG_APCC_DBOX_1	696:704	Mutation rewiring degron network	0.3056
p.R705C	DO47903	STAD	ICGC	QRYHLQSVI	DEG_APCC_DBOX_1	696:704	Mutation rewiring degron network	0.3056
p.T1709M	TCGA-HZ-A9TJ	PAAD	TCGA	PETPEKT	DEG_SCF_FBW7_1	1703:1709	Mutation altering degron motif	0.7423
p.T1709M	DO223715	PAAD	ICGC	PETPEKT	DEG_SCF_FBW7_1	1703:1709	Mutation altering degron motif	0.7423
p.S1126C	TCGA-K4-A54R	BLCA	TCGA	SRPALSPLG	DEG_APCC_DBOX_1	1130:1138	Mutation rewiring degron network	0.2222
p.S1126C	DO48611	BLCA	ICGC	SRPALSPLG	DEG_APCC_DBOX_1	1130:1138	Mutation rewiring degron network	0.2222
p.P116H	TCGA-L5-A8NM	ESCA	TCGA	MHTPGPT	DEG_SCF_FBW7_1	122:128	Mutation rewiring degron network	0.1667
p.S1824F	TCGA-Y8-A8S1	KIRP	TCGA	PGSSS	DEG_SPOP_SBC_1	1816:1820	Mutation rewiring degron network	0.2222
p.S1824F	DO51574	KIRP	ICGC	PGSSS	DEG_SPOP_SBC_1	1816:1820	Mutation rewiring degron network	0.2222
p.S1824F	DO220875	MELA	ICGC	PGSSS	DEG_SPOP_SBC_1	1816:1820	Mutation rewiring degron network	0.2222
p.R114C	TCGA-YD-A9TA	SKCM	TCGA	MHTPGPT	DEG_SCF_FBW7_1	122:128	Mutation rewiring degron network	0.1111
p.R114C	DO219503	SKCM	ICGC	MHTPGPT	DEG_SCF_FBW7_1	122:128	Mutation rewiring degron network	0.1111
p.Y698D	DO228614	GACA	ICGC	QRYHLQSVI	DEG_APCC_DBOX_1	696:704	Mutation altering degron motif	0.6214
p.P1318S	DO233103	GACA	ICGC	LTPPLS	DEG_SCF_FBW7_1	1303:1308	Mutation rewiring degron network	0.0556
p.P1699A	DO233900	GACA	ICGC	PETPEKT	DEG_SCF_FBW7_1	1703:1709	Mutation rewiring degron network	0.2222
p.R1129L	DO228813	LICA	ICGC	SRPALSPLG	DEG_APCC_DBOX_1	1130:1138	Mutation rewiring degron network	0.3056
p.K1713N	DO228985	LICA	ICGC	PETPEKT	DEG_SCF_FBW7_1	1703:1709	Mutation substituting flanking lysine	0.3333
p.V1313L	DO229029	LICA	ICGC	LTPPLS	DEG_SCF_FBW7_1	1303:1308	Mutation rewiring degron network	0.1944
p.W118C	DO229028	LICA	ICGC	MHTPGPT	DEG_SCF_FBW7_1	122:128	Mutation rewiring degron network	0.2222
p.M122I	DO229026	LICA	ICGC	MHTPGPT	DEG_SCF_FBW7_1	122:128	Mutation altering degron motif	0.6507
p.P1297L	DO23416	LINC	ICGC	PPLY	ITCH	1296:1299	Mutation altering degron motif	0.7582
p.A1133T	DO45093	LIRI	ICGC	SRPALSPLG	DEG_APCC_DBOX_1	1130:1138	Mutation altering degron motif	0.6028
p.D711H	DO230931	LUSC	ICGC	QRYHLQSVI	DEG_APCC_DBOX_1	696:704	Mutation rewiring degron network	0.1389
p.D711H	DO224548	LUSC	ICGC	QRYHLQSVI	DEG_APCC_DBOX_1	696:704	Mutation rewiring degron network	0.1389
p.T706S	DO231056	LUSC	ICGC	QRYHLQSVI	DEG_APCC_DBOX_1	696:704	Mutation rewiring degron network	0.2778
p.A1301S	DO231204	LUSC	ICGC	LTPPLS	DEG_SCF_FBW7_1	1303:1308	Mutation rewiring degron network	0.2778
p.A1301S	DO231204	LUSC	ICGC	PPLY	ITCH	1296:1299	Mutation rewiring degron network	0.2778
p.A1809T	DO36556	READ	ICGC	PGSSS	DEG_SPOP_SBC_1	1816:1820	Mutation rewiring degron network	0.1389
p.P1144S	DO229456	SKCA	ICGC	SRPALSPLG	DEG_APCC_DBOX_1	1130:1138	Mutation rewiring degron network	0.1667
p.H699Q	DO43859	UCEC	ICGC	QRYHLQSVI	DEG_APCC_DBOX_1	696:704	Mutation altering degron motif	0.647
p.A1698S	SIDM00216	Colorectal Carcinoma	GDSC	PETPEKT	DEG_SCF_FBW7_1	1703:1709	Mutation rewiring degron network	0.1944
p.A1698S	ACH-000989	Colon/Colorectal Cancer	CCLE	PETPEKT	DEG_SCF_FBW7_1	1703:1709	Mutation rewiring degron network	0.1944
p.A1698S	SNU-175	large intestine	COSMIC	PETPEKT	DEG_SCF_FBW7_1	1703:1709	Mutation rewiring degron network	0.1944
p.D694Y	SIDM01016	T-Lymphoblastic Leukemia	GDSC	QRYHLQSVI	DEG_APCC_DBOX_1	696:704	Mutation rewiring degron network	0.2778
p.D694Y	SIDM01263	T-Lymphoblastic Leukemia	GDSC	QRYHLQSVI	DEG_APCC_DBOX_1	696:704	Mutation rewiring degron network	0.2778
p.D694Y	ACH-000995	Leukemia	CCLE	QRYHLQSVI	DEG_APCC_DBOX_1	696:704	Mutation rewiring degron network	0.2778
p.D694Y	Jurkat	haematopoietic and lymphoid tissue	COSMIC	QRYHLQSVI	DEG_APCC_DBOX_1	696:704	Mutation rewiring degron network	0.2778
p.A1301V	SIDM00789	Colorectal Carcinoma	GDSC	LTPPLS	DEG_SCF_FBW7_1	1303:1308	Mutation rewiring degron network	0.2778
p.A1301V	SIDM00789	Colorectal Carcinoma	GDSC	PPLY	ITCH	1296:1299	Mutation rewiring degron network	0.2778
p.A1301V	ACH-000997	Colon/Colorectal Cancer	CCLE	LTPPLS	DEG_SCF_FBW7_1	1303:1308	Mutation rewiring degron network	0.2778
p.A1301V	ACH-000997	Colon/Colorectal Cancer	CCLE	PPLY	ITCH	1296:1299	Mutation rewiring degron network	0.2778
p.A1301V	ACH-001061	Colon/Colorectal Cancer	CCLE	LTPPLS	DEG_SCF_FBW7_1	1303:1308	Mutation rewiring degron network	0.2778
p.A1301V	ACH-001061	Colon/Colorectal Cancer	CCLE	PPLY	ITCH	1296:1299	Mutation rewiring degron network	0.2778
p.A1301V	HCT-15	large intestine	COSMIC	LTPPLS	DEG_SCF_FBW7_1	1303:1308	Mutation rewiring degron network	0.2778
p.A1301V	HCT-15	large intestine	COSMIC	PPLY	ITCH	1296:1299	Mutation rewiring degron network	0.2778
p.Y993N	SIDM00447	B-Lymphoblastic Leukemia	GDSC	PPAY	ITCH	984:987	Mutation rewiring degron network	0.1667
p.Y993N	ACH-000960	Leukemia	CCLE	PPAY	ITCH	984:987	Mutation rewiring degron network	0.1667
p.V1125I	SIDM00343	Glioblastoma	GDSC	SRPALSPLG	DEG_APCC_DBOX_1	1130:1138	Mutation rewiring degron network	0.1944
p.V1125I	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	SRPALSPLG	DEG_APCC_DBOX_1	1130:1138	Mutation rewiring degron network	0.1944
p.P143L	SIDM01047	Chronic Myelogenous Leukemia	GDSC	PGSST	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.2778
p.P143L	ACH-000295	Leukemia	CCLE	PGSST	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.2778
p.P143L	EM-2	haematopoietic and lymphoid tissue	COSMIC	PGSST	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.2778
p.V1317M	SIDM01154	T-Lymphoblastic Leukemia	GDSC	LTPPLS	DEG_SCF_FBW7_1	1303:1308	Mutation rewiring degron network	0.0833
p.V1317M	ACH-000953	Leukemia	CCLE	LTPPLS	DEG_SCF_FBW7_1	1303:1308	Mutation rewiring degron network	0.0833
p.V1317M	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	LTPPLS	DEG_SCF_FBW7_1	1303:1308	Mutation rewiring degron network	0.0833
p.P1136L	SIDM00282	Colorectal Carcinoma	GDSC	SRPALSPLG	DEG_APCC_DBOX_1	1130:1138	Mutation altering degron motif	0.6471
p.P1136L	ACH-000998	Colon/Colorectal Cancer	CCLE	SRPALSPLG	DEG_APCC_DBOX_1	1130:1138	Mutation altering degron motif	0.6471
p.P1136L	CW-2	large intestine	COSMIC	SRPALSPLG	DEG_APCC_DBOX_1	1130:1138	Mutation altering degron motif	0.6471
p.P974L	SIDM00223	Small Cell Lung Carcinoma	GDSC	PPAY	ITCH	984:987	Mutation rewiring degron network	0.0556
p.P974L	ACH-002144	Lung Cancer	CCLE	PPAY	ITCH	984:987	Mutation rewiring degron network	0.0556
p.P974L	IST-SL1	lung	COSMIC	PPAY	ITCH	984:987	Mutation rewiring degron network	0.0556
p.S1822T	SIDM00018	Acute Myeloid Leukemia	GDSC	PGSSS	DEG_SPOP_SBC_1	1816:1820	Mutation rewiring degron network	0.2778
p.S1822T	ACH-000498	Leukemia	CCLE	PGSSS	DEG_SPOP_SBC_1	1816:1820	Mutation rewiring degron network	0.2778
p.S1822T	KO52	haematopoietic and lymphoid tissue	COSMIC	PGSSS	DEG_SPOP_SBC_1	1816:1820	Mutation rewiring degron network	0.2778
p.P1315L	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	LTPPLS	DEG_SCF_FBW7_1	1303:1308	Mutation rewiring degron network	0.1389
p.P1315L	SIDM00016	Neuroblastoma	GDSC	LTPPLS	DEG_SCF_FBW7_1	1303:1308	Mutation rewiring degron network	0.1389
p.P1315L	ACH-000446	Neuroblastoma	CCLE	LTPPLS	DEG_SCF_FBW7_1	1303:1308	Mutation rewiring degron network	0.1389
p.P1315L	ACH-000637	Esophageal Cancer	CCLE	LTPPLS	DEG_SCF_FBW7_1	1303:1308	Mutation rewiring degron network	0.1389
p.P1315L	KYSE-520	oesophagus	COSMIC	LTPPLS	DEG_SCF_FBW7_1	1303:1308	Mutation rewiring degron network	0.1389
p.P1703T	SIDM00164	Biliary Tract Carcinoma	GDSC	PETPEKT	DEG_SCF_FBW7_1	1703:1709	Mutation altering degron motif	0.7031
p.P1703T	ACH-000209	Bile Duct Cancer	CCLE	PETPEKT	DEG_SCF_FBW7_1	1703:1709	Mutation altering degron motif	0.7031
p.P116L	SIDM01774	Pancreatic Carcinoma	GDSC	MHTPGPT	DEG_SCF_FBW7_1	122:128	Mutation rewiring degron network	0.1667
p.P116L	ACH-000205	Pancreatic Cancer	CCLE	MHTPGPT	DEG_SCF_FBW7_1	122:128	Mutation rewiring degron network	0.1667
p.S1126Y	ACH-000681	Lung Cancer	CCLE	SRPALSPLG	DEG_APCC_DBOX_1	1130:1138	Mutation rewiring degron network	0.2222
p.D1141N	ACH-000964	Leukemia	CCLE	SRPALSPLG	DEG_APCC_DBOX_1	1130:1138	Mutation rewiring degron network	0.25
p.D1821N	ACH-000964	Leukemia	CCLE	PGSSS	DEG_SPOP_SBC_1	1816:1820	Mutation rewiring degron network	0.3056
p.T1810A	ACH-001377	Pancreatic Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	1816:1820	Mutation rewiring degron network	0.1667
p.G1812V	ACH-001413	Bladder Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	1816:1820	Mutation rewiring degron network	0.2222
p.R1294P	ACH-001490	Lung Cancer	CCLE	LTPPLS	DEG_SCF_FBW7_1	1303:1308	Mutation rewiring degron network	0.0833
p.R1294P	ACH-001490	Lung Cancer	CCLE	PPLY	ITCH	1296:1299	Mutation rewiring degron network	0.2778
p.R1294P	COR-L321	NS	COSMIC	LTPPLS	DEG_SCF_FBW7_1	1303:1308	Mutation rewiring degron network	0.0833
p.R1294P	COR-L321	NS	COSMIC	PPLY	ITCH	1296:1299	Mutation rewiring degron network	0.2778
p.R705H	ACH-001610	Brain Cancer	CCLE	QRYHLQSVI	DEG_APCC_DBOX_1	696:704	Mutation rewiring degron network	0.3056
p.P146S	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PGSST	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.1944
p.E148K	A431	skin	COSMIC	PGSST	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRR12

UniProt ID: Q9ULL5

Entrez ID: 57479

Protein name: Proline-rich protein 12

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRR12 in