DegronMD

Uniprot ID: Q9ULL5

Source protein: Proline-rich protein 12

Source gene: PRR12

Class: DEG_SCF_FBW7_1

Location: 1703:1709

E3 ligase: FBXW7

DEGRON score: 0.7629

ASA_SCORE: 114.2286

COIL: 0.9559

CONS_SCORE: 0

DSS_SCORE: 0.879

HELIX: 0.022

FCONS_SCORE: 0

RIG_SCORE: 0.4835

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1708R	TCGA-AP-A1DP	UCEC	TCGA	PETPEKT	DEG_SCF_FBW7_1	0.6126
p.K1708R	DO42336	UCEC	ICGC	PETPEKT	DEG_SCF_FBW7_1	0.6126
p.T1709M	TCGA-HZ-A9TJ	PAAD	TCGA	PETPEKT	DEG_SCF_FBW7_1	0.7423
p.T1709M	DO223715	PAAD	ICGC	PETPEKT	DEG_SCF_FBW7_1	0.7423
p.P1699A	DO233900	GACA	ICGC	PETPEKT	DEG_SCF_FBW7_1	0.2222
p.K1713N	DO228985	LICA	ICGC	PETPEKT	DEG_SCF_FBW7_1	0.3333
p.A1698S	SIDM00216	Colorectal Carcinoma	GDSC	PETPEKT	DEG_SCF_FBW7_1	0.1944
p.A1698S	ACH-000989	Colon/Colorectal Cancer	CCLE	PETPEKT	DEG_SCF_FBW7_1	0.1944
p.A1698S	SNU-175	large_intestine	COSMIC	PETPEKT	DEG_SCF_FBW7_1	0.1944
p.P1703T	SIDM00164	Biliary Tract Carcinoma	GDSC	PETPEKT	DEG_SCF_FBW7_1	0.7031
p.P1703T	ACH-000209	Bile Duct Cancer	CCLE	PETPEKT	DEG_SCF_FBW7_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULL5	Proline-rich protein 12	DEG_SCF_FBW7_1	1703:1709	PETPEKT	FBXW7	0.7629	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons