DegronMD

Uniprot ID: Q9ULL5

Source protein: Proline-rich protein 12

Source gene: PRR12

Class: DEG_SCF_FBW7_1

Location: 1303:1308

E3 ligase: FBXW7

DEGRON score: 0.995

ASA_SCORE: 100.2333

COIL: 0.9782

CONS_SCORE: 0

DSS_SCORE: 0.5929

HELIX: 0.0072

FCONS_SCORE: 0

RIG_SCORE: 0.592

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1294C	TCGA-AH-6644	READ	TCGA	LTPPLS	DEG_SCF_FBW7_1	0.0833
p.R1294C	DO37237	READ	ICGC	LTPPLS	DEG_SCF_FBW7_1	0.0833
p.T1304M	TCGA-AX-A1CE	UCEC	TCGA	LTPPLS	DEG_SCF_FBW7_1	0.8534
p.T1304M	DO27128	LUSC	ICGC	LTPPLS	DEG_SCF_FBW7_1	0.8534
p.T1304M	DO42280	UCEC	ICGC	LTPPLS	DEG_SCF_FBW7_1	0.8534
p.P1306L	TCGA-BC-A69H	LIHC	TCGA	LTPPLS	DEG_SCF_FBW7_1	0.6471
p.P1306L	DO44927	LIHC	ICGC	LTPPLS	DEG_SCF_FBW7_1	0.6471
p.R1294H	TCGA-D5-6540	COAD	TCGA	LTPPLS	DEG_SCF_FBW7_1	0.0833
p.R1294H	DO9708	COAD	ICGC	LTPPLS	DEG_SCF_FBW7_1	0.0833
p.P1306A	TCGA-HQ-A5NE	BLCA	TCGA	LTPPLS	DEG_SCF_FBW7_1	0.6392
p.P1306A	DO51900	BLCA	ICGC	LTPPLS	DEG_SCF_FBW7_1	0.6392
p.P1318S	DO233103	GACA	ICGC	LTPPLS	DEG_SCF_FBW7_1	0.0556
p.V1313L	DO229029	LICA	ICGC	LTPPLS	DEG_SCF_FBW7_1	0.1944
p.A1301S	DO231204	LUSC	ICGC	LTPPLS	DEG_SCF_FBW7_1	0.2778
p.A1301V	SIDM00789	Colorectal Carcinoma	GDSC	LTPPLS	DEG_SCF_FBW7_1	0.2778
p.A1301V	ACH-000997	Colon/Colorectal Cancer	CCLE	LTPPLS	DEG_SCF_FBW7_1	0.2778
p.A1301V	ACH-001061	Colon/Colorectal Cancer	CCLE	LTPPLS	DEG_SCF_FBW7_1	0.2778
p.A1301V	HCT-15	large_intestine	COSMIC	LTPPLS	DEG_SCF_FBW7_1	0.2778
p.V1317M	SIDM01154	T-Lymphoblastic Leukemia	GDSC	LTPPLS	DEG_SCF_FBW7_1	0.0833
p.V1317M	ACH-000953	Leukemia	CCLE	LTPPLS	DEG_SCF_FBW7_1	0.0833
p.V1317M	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	LTPPLS	DEG_SCF_FBW7_1	0.0833
p.P1315L	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	LTPPLS	DEG_SCF_FBW7_1	0.1389
p.P1315L	SIDM00016	Neuroblastoma	GDSC	LTPPLS	DEG_SCF_FBW7_1	0.1389
p.P1315L	ACH-000446	Neuroblastoma	CCLE	LTPPLS	DEG_SCF_FBW7_1	0.1389
p.P1315L	ACH-000637	Esophageal Cancer	CCLE	LTPPLS	DEG_SCF_FBW7_1	0.1389
p.P1315L	KYSE-520	oesophagus	COSMIC	LTPPLS	DEG_SCF_FBW7_1	0.1389
p.R1294P	ACH-001490	Lung Cancer	CCLE	LTPPLS	DEG_SCF_FBW7_1	0.0833
p.R1294P	COR-L321	NS	COSMIC	LTPPLS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPN9	E3 ubiquitin-protein ligase TRIM33	DEG_SCF_FBW7_1	814:819	LTPPLS	FBXW7	0.9985	More...
Q9ULL5	Proline-rich protein 12	DEG_SCF_FBW7_1	1303:1308	LTPPLS	FBXW7	0.995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPPLS

Degron related mutations and impact score

Drug responses associated with PRR12 mutations

All proteins holding degron of LTPPLS