DegronMD

Uniprot ID: Q9UPN9

Source protein: E3 ubiquitin-protein ligase TRIM33

Source gene: TRIM33

Class: DEG_SCF_FBW7_1

Location: 814:819

E3 ligase: FBXW7

DEGRON score: 0.9985

ASA_SCORE: 84

COIL: 0.9327

CONS_SCORE: 0.434

DSS_SCORE: 0.5496

HELIX: 0.0358

FCONS_SCORE: 0.9881

RIG_SCORE: 0.6301

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L822V	TCGA-30-1855	OV	TCGA	LTPPLS	DEG_SCF_FBW7_1	0.25
p.L822V	DO32666	OV	ICGC	LTPPLS	DEG_SCF_FBW7_1	0.25
p.H823N	DO228971	LICA	ICGC	LTPPLS	DEG_SCF_FBW7_1	0.2222
p.H823N	DO229006	LICA	ICGC	LTPPLS	DEG_SCF_FBW7_1	0.2222
p.P817T	DO229015	LICA	ICGC	LTPPLS	DEG_SCF_FBW7_1	0.5919
p.T820N	DO229025	LICA	ICGC	LTPPLS	DEG_SCF_FBW7_1	0.75
p.L828M	SIDM02068	Esophageal Carcinoma	GDSC	LTPPLS	DEG_SCF_FBW7_1	0.0833
p.E811K	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	LTPPLS	DEG_SCF_FBW7_1	0.25
p.E811K	ACH-000886	Lung Cancer	CCLE	LTPPLS	DEG_SCF_FBW7_1	0.25
p.E811K	NCI-H2009	lung	COSMIC	LTPPLS	DEG_SCF_FBW7_1	0.25
p.C805Y	SIDM00986	Head and Neck Carcinoma	GDSC	LTPPLS	DEG_SCF_FBW7_1	0.0833
p.C805Y	ACH-000548	Head and Neck Cancer	CCLE	LTPPLS	DEG_SCF_FBW7_1	0.0833
p.C805Y	BHY	upper_aerodigestive_tract	COSMIC	LTPPLS	DEG_SCF_FBW7_1	0.0833
p.N821S	SIDM01525	Acute Myeloid Leukemia	GDSC	LTPPLS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPN9	E3 ubiquitin-protein ligase TRIM33	DEG_SCF_FBW7_1	814:819	LTPPLS	FBXW7	0.9985	More...
Q9ULL5	Proline-rich protein 12	DEG_SCF_FBW7_1	1303:1308	LTPPLS	FBXW7	0.995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons