DegronMD - Q9UPN9(TRIM33)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G732C	TCGA-17-Z017	LUAD	TCGA	PPSTS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.0556
p.L822V	TCGA-30-1855	OV	TCGA	LTPPLS	DEG_SCF_FBW7_1	814:819	Mutation rewiring degron network	0.25
p.L822V	DO32666	OV	ICGC	LTPPLS	DEG_SCF_FBW7_1	814:819	Mutation rewiring degron network	0.25
p.S705L	TCGA-A6-3808	COAD	TCGA	AGSSS	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.0556
p.S694N	TCGA-AX-A05Z	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	691:695	Mutation altering degron motif	0.7069
p.S694N	DO40884	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	691:695	Mutation altering degron motif	0.7069
p.Q687H	TCGA-DU-A7T6	LGG	TCGA	AGSSS	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.2222
p.Q687H	DO51814	LGG	ICGC	AGSSS	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.2222
p.Q538K	TCGA-DX-A6YV	SARC	TCGA	VPTTT	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.1944
p.G752C	TCGA-EE-A2GO	SKCM	TCGA	PPSTS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.1667
p.L696F	TCGA-EM-A3SZ	THCA	TCGA	AGSSS	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.3056
p.L696F	DO48129	THCA	ICGC	AGSSS	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.3056
p.Q552H	TCGA-FI-A2D5	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.1944
p.D682H	DO223599	BLCA	ICGC	AGSSS	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.0833
p.D682A	DO10172	COAD	ICGC	AGSSS	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.0833
p.E535K	DO9876	COAD	ICGC	VPTTT	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.1111
p.E535K	DO43907	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.1111
p.S736C	DO50441	ESAD	ICGC	PPSTS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.1667
p.H823N	DO228971	LICA	ICGC	LTPPLS	DEG_SCF_FBW7_1	814:819	Mutation rewiring degron network	0.2222
p.H823N	DO229006	LICA	ICGC	LTPPLS	DEG_SCF_FBW7_1	814:819	Mutation rewiring degron network	0.2222
p.T546K	DO228986	LICA	ICGC	VPTTT	DEG_SPOP_SBC_1	543:547	Mutation altering degron motif	0.7306
p.P817T	DO229015	LICA	ICGC	LTPPLS	DEG_SCF_FBW7_1	814:819	Mutation altering degron motif	0.5919
p.P739H	DO229015	LICA	ICGC	PPSTS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.25
p.T820N	DO229025	LICA	ICGC	LTPPLS	DEG_SCF_FBW7_1	814:819	Mutation blocking phosphorylation signal	0.75
p.S746P	DO228338	MALY	ICGC	PPSTS	DEG_SPOP_SBC_1	742:746	Mutation altering degron motif	0.6752
p.E735K	DO228338	MALY	ICGC	PPSTS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.1389
p.L699V	DO52686	MALY	ICGC	AGSSS	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.2222
p.P544T	DO229229	THCA	ICGC	VPTTT	DEG_SPOP_SBC_1	543:547	Mutation altering degron motif	0.5919
p.K536Q	DO43971	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.1389
p.R751Q	SIDM02055	Colorectal Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.1944
p.R751Q	SIDM00697	Small Cell Lung Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.1944
p.R751Q	ACH-000830	Lung Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.1944
p.R751Q	NCI-H1436	lung	COSMIC	PPSTS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.1944
p.L828M	SIDM02068	Esophageal Carcinoma	GDSC	LTPPLS	DEG_SCF_FBW7_1	814:819	Mutation rewiring degron network	0.0833
p.E811K	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	LTPPLS	DEG_SCF_FBW7_1	814:819	Mutation rewiring degron network	0.25
p.E811K	ACH-000886	Lung Cancer	CCLE	LTPPLS	DEG_SCF_FBW7_1	814:819	Mutation rewiring degron network	0.25
p.E811K	NCI-H2009	lung	COSMIC	LTPPLS	DEG_SCF_FBW7_1	814:819	Mutation rewiring degron network	0.25
p.C805Y	SIDM00986	Head and Neck Carcinoma	GDSC	LTPPLS	DEG_SCF_FBW7_1	814:819	Mutation rewiring degron network	0.0833
p.C805Y	ACH-000548	Head and Neck Cancer	CCLE	LTPPLS	DEG_SCF_FBW7_1	814:819	Mutation rewiring degron network	0.0833
p.C805Y	BHY	upper aerodigestive tract	COSMIC	LTPPLS	DEG_SCF_FBW7_1	814:819	Mutation rewiring degron network	0.0833
p.N821S	SIDM01525	Acute Myeloid Leukemia	GDSC	LTPPLS	DEG_SCF_FBW7_1	814:819	Mutation rewiring degron network	0.2778

Kaplan plot for TRIM33 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRIM33

UniProt ID: Q9UPN9

Entrez ID: 51592

Protein name: E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRIM33 in