DegronMD

Uniprot ID: Q9ULL5

Source protein: Proline-rich protein 12

Source gene: PRR12

Class: DEG_APCC_DBOX_1

Location: 1130:1138

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9895

ASA_SCORE: 90.0778

COIL: 0.9577

CONS_SCORE: 0.549

DSS_SCORE: 0.4613

HELIX: 0.019

FCONS_SCORE: 0.8751

RIG_SCORE: 0.6295

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1120H	TCGA-A5-A1OF	UCEC	TCGA	SRPALSPLG	DEG_APCC_DBOX_1	0.0556
p.R1120H	DO42568	UCEC	ICGC	SRPALSPLG	DEG_APCC_DBOX_1	0.0556
p.R1131C	TCGA-AA-A01R	COAD	TCGA	SRPALSPLG	DEG_APCC_DBOX_1	0.8301
p.R1131C	DO7934	COAD	ICGC	SRPALSPLG	DEG_APCC_DBOX_1	0.8301
p.S1127C	TCGA-BC-A3KF	LIHC	TCGA	SRPALSPLG	DEG_APCC_DBOX_1	0.25
p.S1127C	DO22990	LIHC	ICGC	SRPALSPLG	DEG_APCC_DBOX_1	0.25
p.S1126C	TCGA-K4-A54R	BLCA	TCGA	SRPALSPLG	DEG_APCC_DBOX_1	0.2222
p.S1126C	DO48611	BLCA	ICGC	SRPALSPLG	DEG_APCC_DBOX_1	0.2222
p.R1129L	DO228813	LICA	ICGC	SRPALSPLG	DEG_APCC_DBOX_1	0.3056
p.A1133T	DO45093	LIRI	ICGC	SRPALSPLG	DEG_APCC_DBOX_1	0.6028
p.P1144S	DO229456	SKCA	ICGC	SRPALSPLG	DEG_APCC_DBOX_1	0.1667
p.V1125I	SIDM00343	Glioblastoma	GDSC	SRPALSPLG	DEG_APCC_DBOX_1	0.1944
p.V1125I	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	SRPALSPLG	DEG_APCC_DBOX_1	0.1944
p.P1136L	SIDM00282	Colorectal Carcinoma	GDSC	SRPALSPLG	DEG_APCC_DBOX_1	0.6471
p.P1136L	ACH-000998	Colon/Colorectal Cancer	CCLE	SRPALSPLG	DEG_APCC_DBOX_1	0.6471
p.P1136L	CW-2	large_intestine	COSMIC	SRPALSPLG	DEG_APCC_DBOX_1	0.6471
p.S1126Y	ACH-000681	Lung Cancer	CCLE	SRPALSPLG	DEG_APCC_DBOX_1	0.2222
p.D1141N	ACH-000964	Leukemia	CCLE	SRPALSPLG	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULL5	Proline-rich protein 12	DEG_APCC_DBOX_1	1130:1138	SRPALSPLG	APC,CDC20,FZR1	0.9895	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons