DegronMD

Uniprot ID: Q9ULL5

Source protein: Proline-rich protein 12

Source gene: PRR12

Class: DEG_APCC_DBOX_1

Location: 696:704

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9523

ASA_SCORE: 109.2

COIL: 0.7973

CONS_SCORE: 0.3803

DSS_SCORE: 0.5146

HELIX: 0.157

FCONS_SCORE: 0.8792

RIG_SCORE: 0.7841

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K692Q	TCGA-2Z-A9JO	KIRP	TCGA	QRYHLQSVI	DEG_APCC_DBOX_1	0.3333
p.K692Q	DO219681	KIRP	ICGC	QRYHLQSVI	DEG_APCC_DBOX_1	0.3333
p.Y688C	TCGA-56-6546	LUSC	TCGA	QRYHLQSVI	DEG_APCC_DBOX_1	0.1111
p.Y688C	DO26542	LUSC	ICGC	QRYHLQSVI	DEG_APCC_DBOX_1	0.1111
p.A691P	TCGA-BH-A1FN	BRCA	TCGA	QRYHLQSVI	DEG_APCC_DBOX_1	0.1944
p.A691P	DO5214	BRCA	ICGC	QRYHLQSVI	DEG_APCC_DBOX_1	0.1944
p.E712K	TCGA-BT-A0YX	BLCA	TCGA	QRYHLQSVI	DEG_APCC_DBOX_1	0.1111
p.E712K	DO516	BLCA	ICGC	QRYHLQSVI	DEG_APCC_DBOX_1	0.1111
p.S702C	TCGA-CR-7369	HNSC	TCGA	QRYHLQSVI	DEG_APCC_DBOX_1	0.643
p.S702C	DO14934	HNSC	ICGC	QRYHLQSVI	DEG_APCC_DBOX_1	0.643
p.V703A	TCGA-FS-A4F5	SKCM	TCGA	QRYHLQSVI	DEG_APCC_DBOX_1	0.6936
p.V703A	DO37881	SKCM	ICGC	QRYHLQSVI	DEG_APCC_DBOX_1	0.6936
p.Q696K	TCGA-HE-7129	KIRP	TCGA	QRYHLQSVI	DEG_APCC_DBOX_1	0.5833
p.Q696K	DO20786	KIRP	ICGC	QRYHLQSVI	DEG_APCC_DBOX_1	0.5833
p.R705C	TCGA-HU-A4H3	STAD	TCGA	QRYHLQSVI	DEG_APCC_DBOX_1	0.3056
p.R705C	DO47903	STAD	ICGC	QRYHLQSVI	DEG_APCC_DBOX_1	0.3056
p.Y698D	DO228614	GACA	ICGC	QRYHLQSVI	DEG_APCC_DBOX_1	0.6214
p.D711H	DO230931	LUSC	ICGC	QRYHLQSVI	DEG_APCC_DBOX_1	0.1389
p.D711H	DO224548	LUSC	ICGC	QRYHLQSVI	DEG_APCC_DBOX_1	0.1389
p.T706S	DO231056	LUSC	ICGC	QRYHLQSVI	DEG_APCC_DBOX_1	0.2778
p.H699Q	DO43859	UCEC	ICGC	QRYHLQSVI	DEG_APCC_DBOX_1	0.647
p.D694Y	SIDM01016	T-Lymphoblastic Leukemia	GDSC	QRYHLQSVI	DEG_APCC_DBOX_1	0.2778
p.D694Y	SIDM01263	T-Lymphoblastic Leukemia	GDSC	QRYHLQSVI	DEG_APCC_DBOX_1	0.2778
p.D694Y	ACH-000995	Leukemia	CCLE	QRYHLQSVI	DEG_APCC_DBOX_1	0.2778
p.D694Y	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	QRYHLQSVI	DEG_APCC_DBOX_1	0.2778
p.R705H	ACH-001610	Brain Cancer	CCLE	QRYHLQSVI	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULL5	Proline-rich protein 12	DEG_APCC_DBOX_1	696:704	QRYHLQSVI	APC,CDC20,FZR1	0.9523	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QRYHLQSVI

Degron related mutations and impact score

Drug responses associated with PRR12 mutations

All proteins holding degron of QRYHLQSVI