DegronMD

Uniprot ID: Q9ULL5

Source protein: Proline-rich protein 12

Source gene: PRR12

Class: DEG_SCF_FBW7_1

Location: 122:128

E3 ligase: FBXW7

DEGRON score: 0.9756

ASA_SCORE: 88.2286

COIL: 0.9301

CONS_SCORE: 0.5246

DSS_SCORE: 0.4997

HELIX: 0.051

FCONS_SCORE: 1.1646

RIG_SCORE: 0.6817

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S133L	TCGA-AX-A2HC	UCEC	TCGA	MHTPGPT	DEG_SCF_FBW7_1	0.1944
p.S133L	DO41572	UCEC	ICGC	MHTPGPT	DEG_SCF_FBW7_1	0.1944
p.T124M	TCGA-AZ-6601	COAD	TCGA	MHTPGPT	DEG_SCF_FBW7_1	0.7423
p.T124M	DO8119	COAD	ICGC	MHTPGPT	DEG_SCF_FBW7_1	0.7423
p.G134S	TCGA-DF-A2KN	UCEC	TCGA	MHTPGPT	DEG_SCF_FBW7_1	0.1667
p.G134S	DO223282	UCEC	ICGC	MHTPGPT	DEG_SCF_FBW7_1	0.1667
p.T120A	TCGA-FY-A4B3	THCA	TCGA	MHTPGPT	DEG_SCF_FBW7_1	0.2778
p.T120A	DO48072	THCA	ICGC	MHTPGPT	DEG_SCF_FBW7_1	0.2778
p.P116H	TCGA-L5-A8NM	ESCA	TCGA	MHTPGPT	DEG_SCF_FBW7_1	0.1667
p.R114C	TCGA-YD-A9TA	SKCM	TCGA	MHTPGPT	DEG_SCF_FBW7_1	0.1111
p.R114C	DO219503	SKCM	ICGC	MHTPGPT	DEG_SCF_FBW7_1	0.1111
p.W118C	DO229028	LICA	ICGC	MHTPGPT	DEG_SCF_FBW7_1	0.2222
p.M122I	DO229026	LICA	ICGC	MHTPGPT	DEG_SCF_FBW7_1	0.6507
p.P116L	SIDM01774	Pancreatic Carcinoma	GDSC	MHTPGPT	DEG_SCF_FBW7_1	0.1667
p.P116L	ACH-000205	Pancreatic Cancer	CCLE	MHTPGPT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULL5	Proline-rich protein 12	DEG_SCF_FBW7_1	122:128	MHTPGPT	FBXW7	0.9756	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons