DegronMD - Q13164(MAPK7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G674W	TCGA-05-4396	LUAD	TCGA	PGSST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.2778
p.G674W	DO23838	LUAD	ICGC	PGSST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.2778
p.P589R	TCGA-05-4430	LUAD	TCGA	PAPTPTPT	DEG_SCF_FBW7_1	591:598	Mutation rewiring degron network	0.2778
p.P589R	DO23750	LUAD	ICGC	PAPTPTPT	DEG_SCF_FBW7_1	591:598	Mutation rewiring degron network	0.2778
p.A653T	TCGA-AA-3947	COAD	TCGA	ATSTS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.1944
p.A653T	DO8192	COAD	ICGC	ATSTS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.1944
p.A653T	SIDM00596	Endometrial Carcinoma	GDSC	ATSTS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.1944
p.A653T	ACH-001517	Endometrial/Uterine Cancer	CCLE	ATSTS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.1944
p.A653T	HEC-1	endometrium	COSMIC	ATSTS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.1944
p.A632V	TCGA-D1-A17Q	UCEC	TCGA	AGSTS	DEG_SPOP_SBC_1	621:625	Mutation rewiring degron network	0.1389
p.A632V	DO41903	UCEC	ICGC	AGSTS	DEG_SPOP_SBC_1	621:625	Mutation rewiring degron network	0.1389
p.P673H	TCGA-D3-A2JG	SKCM	TCGA	PGSST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.25
p.P673H	DO47613	SKCM	ICGC	PGSST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.25
p.P605S	TCGA-GV-A3JX	BLCA	TCGA	PAPTPTPT	DEG_SCF_FBW7_1	591:598	Mutation rewiring degron network	0.1389
p.P605S	DO448	BLCA	ICGC	PAPTPTPT	DEG_SCF_FBW7_1	591:598	Mutation rewiring degron network	0.1389
p.S585F	TCGA-MA-AA41	CESC	TCGA	PAPTPTPT	DEG_SCF_FBW7_1	591:598	Mutation rewiring degron network	0.1667
p.S585F	DO219723	CESC	ICGC	PAPTPTPT	DEG_SCF_FBW7_1	591:598	Mutation rewiring degron network	0.1667
p.S585F	ACH-000915	Skin Cancer	CCLE	PAPTPTPT	DEG_SCF_FBW7_1	591:598	Mutation rewiring degron network	0.1667
p.P607S	TCGA-VS-A9V5	CESC	TCGA	PAPTPTPT	DEG_SCF_FBW7_1	591:598	Mutation rewiring degron network	0.0833
p.P607S	DO51650	CESC	ICGC	PAPTPTPT	DEG_SCF_FBW7_1	591:598	Mutation rewiring degron network	0.0833
p.P589S	DO229010	COCA	ICGC	PAPTPTPT	DEG_SCF_FBW7_1	591:598	Mutation rewiring degron network	0.2778
p.P589S	SIDM00377	Other Sarcomas	GDSC	PAPTPTPT	DEG_SCF_FBW7_1	591:598	Mutation rewiring degron network	0.2778
p.P589S	SIDM00165	Other Solid Cancers	GDSC	PAPTPTPT	DEG_SCF_FBW7_1	591:598	Mutation rewiring degron network	0.2778
p.P589S	SIDM01611	Endometrial Carcinoma	GDSC	PAPTPTPT	DEG_SCF_FBW7_1	591:598	Mutation rewiring degron network	0.2778
p.P634L	DO222309	DLBC	ICGC	AGSTS	DEG_SPOP_SBC_1	621:625	Mutation rewiring degron network	0.0833
p.P595S	DO233871	GACA	ICGC	PAPTPTPT	DEG_SCF_FBW7_1	591:598	Mutation altering degron motif	0.6752
p.S662G	DO231964	LICA	ICGC	ATSTS	DEG_SPOP_SBC_1	658:662	Mutation altering degron motif	0.6993
p.P652H	DO220878	MELA	ICGC	ATSTS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.1667
p.P635T	DO50662	ORCA	ICGC	AGSTS	DEG_SPOP_SBC_1	621:625	Mutation rewiring degron network	0.0556
p.S585C	DO49448	PACA	ICGC	PAPTPTPT	DEG_SCF_FBW7_1	591:598	Mutation rewiring degron network	0.1667
p.S679N	DO229259	THCA	ICGC	PGSST	DEG_SPOP_SBC_1	676:680	Mutation altering degron motif	0.7069
p.I649L	DO229259	THCA	ICGC	ATSTS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.0833
p.L669F	SIDM00373	Endometrial Carcinoma	GDSC	ATSTS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.1389
p.L669F	SIDM00373	Endometrial Carcinoma	GDSC	PGSST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.1389
p.L669F	SNG-M	endometrium	COSMIC	ATSTS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.1389
p.L669F	SNG-M	endometrium	COSMIC	PGSST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.1389
p.G622S	SIDM01245	T-Lymphoblastic Leukemia	GDSC	AGSTS	DEG_SPOP_SBC_1	621:625	Mutation altering degron motif	0.5882
p.G622S	SIDM00991	T-Lymphoblastic Leukemia	GDSC	AGSTS	DEG_SPOP_SBC_1	621:625	Mutation altering degron motif	0.5882
p.G622S	ACH-000519	Leukemia	CCLE	AGSTS	DEG_SPOP_SBC_1	621:625	Mutation altering degron motif	0.5882
p.G622S	ACH-002216	Leukemia	CCLE	AGSTS	DEG_SPOP_SBC_1	621:625	Mutation altering degron motif	0.5882
p.G622S	BE-13	haematopoietic and lymphoid tissue	COSMIC	AGSTS	DEG_SPOP_SBC_1	621:625	Mutation altering degron motif	0.5882
p.T661I	SIDM00060	Ovarian Carcinoma	GDSC	ATSTS	DEG_SPOP_SBC_1	658:662	Mutation altering degron motif	0.7078
p.A658V	SIDM00282	Colorectal Carcinoma	GDSC	ATSTS	DEG_SPOP_SBC_1	658:662	Mutation altering degron motif	0.5825
p.A658V	ACH-000998	Colon/Colorectal Cancer	CCLE	ATSTS	DEG_SPOP_SBC_1	658:662	Mutation altering degron motif	0.5825
p.A658V	CW-2	large intestine	COSMIC	ATSTS	DEG_SPOP_SBC_1	658:662	Mutation altering degron motif	0.5825
p.T603S	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	PAPTPTPT	DEG_SCF_FBW7_1	591:598	Mutation rewiring degron network	0.1944
p.T603S	ACH-000837	Lung Cancer	CCLE	PAPTPTPT	DEG_SCF_FBW7_1	591:598	Mutation rewiring degron network	0.1944
p.A621T	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	AGSTS	DEG_SPOP_SBC_1	621:625	Mutation altering degron motif	0.7139
p.A621T	ACH-001137	Lung Cancer	CCLE	AGSTS	DEG_SPOP_SBC_1	621:625	Mutation altering degron motif	0.7139
p.A621T	NCI-H1993	lung	COSMIC	AGSTS	DEG_SPOP_SBC_1	621:625	Mutation altering degron motif	0.7139
p.P655L	SIDM00807	Bladder Carcinoma	GDSC	ATSTS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.25
p.P655L	ACH-000905	Bladder Cancer	CCLE	ATSTS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.25
p.P655L	5637	urinary tract	COSMIC	ATSTS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.25
p.A665T	SIDM00613	Glioblastoma	GDSC	ATSTS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.25
p.A665T	ACH-000231	Brain Cancer	CCLE	ATSTS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.25
p.A665T	KALS-1	central nervous system	COSMIC	ATSTS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.25
p.A653V	SIDM01086	B-Lymphoblastic Leukemia	GDSC	ATSTS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.1944
p.A653V	ACH-000874	Leukemia	CCLE	ATSTS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.1944
p.A653V	RS4-11	haematopoietic and lymphoid tissue	COSMIC	ATSTS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.1944
p.P587L	ACH-000265	Pancreatic Cancer	CCLE	PAPTPTPT	DEG_SCF_FBW7_1	591:598	Mutation rewiring degron network	0.2222
p.P587L	ACH-002046	Endometrial/Uterine Cancer	CCLE	PAPTPTPT	DEG_SCF_FBW7_1	591:598	Mutation rewiring degron network	0.2222
p.L583I	ACH-000956	Prostate Cancer	CCLE	PAPTPTPT	DEG_SCF_FBW7_1	591:598	Mutation rewiring degron network	0.1111
p.I653T	Daoy	central nervous system	COSMIC	ATSTS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.1944
p.E584D	CW-2	large intestine	COSMIC	PAPTPTPT	DEG_SCF_FBW7_1	591:598	Mutation blocking phosphorylation signal	0.5833
p.P589H	HCT-15	large intestine	COSMIC	PAPTPTPT	DEG_SCF_FBW7_1	591:598	Mutation rewiring degron network	0.2778
p.E584K	IM-95	stomach	COSMIC	PAPTPTPT	DEG_SCF_FBW7_1	591:598	Mutation blocking phosphorylation signal	0.5833
p.M666V	COLO-678	large intestine	COSMIC	ATSTS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.2222
p.M666V	COLO-678	large intestine	COSMIC	PGSST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.0556
p.D622N	H2795	pleura	COSMIC	AGSTS	DEG_SPOP_SBC_1	621:625	Mutation altering degron motif	0.6932

Kaplan plot for MAPK7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAPK7

UniProt ID: Q13164

Entrez ID: 5598

Protein name: Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAPK7 in