DegronMD

Uniprot ID: Q13164

Source protein: Mitogen-activated protein kinase 7

Source gene: MAPK7

Class: DEG_SCF_FBW7_1

Location: 591:598

E3 ligase: FBXW7

DEGRON score: 0.9857

ASA_SCORE: 96.1125

COIL: 0.9675

CONS_SCORE: 0.3444

DSS_SCORE: 0.7455

HELIX: 0.0095

FCONS_SCORE: 0.9887

RIG_SCORE: 0.5075

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P589R	TCGA-05-4430	LUAD	TCGA	PAPTPTPT	DEG_SCF_FBW7_1	0.2778
p.P589R	DO23750	LUAD	ICGC	PAPTPTPT	DEG_SCF_FBW7_1	0.2778
p.P605S	TCGA-GV-A3JX	BLCA	TCGA	PAPTPTPT	DEG_SCF_FBW7_1	0.1389
p.P605S	DO448	BLCA	ICGC	PAPTPTPT	DEG_SCF_FBW7_1	0.1389
p.S585F	TCGA-MA-AA41	CESC	TCGA	PAPTPTPT	DEG_SCF_FBW7_1	0.1667
p.S585F	DO219723	CESC	ICGC	PAPTPTPT	DEG_SCF_FBW7_1	0.1667
p.S585F	ACH-000915	Skin Cancer	CCLE	PAPTPTPT	DEG_SCF_FBW7_1	0.1667
p.P607S	TCGA-VS-A9V5	CESC	TCGA	PAPTPTPT	DEG_SCF_FBW7_1	0.0833
p.P607S	DO51650	CESC	ICGC	PAPTPTPT	DEG_SCF_FBW7_1	0.0833
p.P589S	DO229010	COCA	ICGC	PAPTPTPT	DEG_SCF_FBW7_1	0.2778
p.P589S	SIDM00377	Other Sarcomas	GDSC	PAPTPTPT	DEG_SCF_FBW7_1	0.2778
p.P589S	SIDM00165	Other Solid Cancers	GDSC	PAPTPTPT	DEG_SCF_FBW7_1	0.2778
p.P589S	SIDM01611	Endometrial Carcinoma	GDSC	PAPTPTPT	DEG_SCF_FBW7_1	0.2778
p.P595S	DO233871	GACA	ICGC	PAPTPTPT	DEG_SCF_FBW7_1	0.6752
p.S585C	DO49448	PACA	ICGC	PAPTPTPT	DEG_SCF_FBW7_1	0.1667
p.T603S	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	PAPTPTPT	DEG_SCF_FBW7_1	0.1944
p.T603S	ACH-000837	Lung Cancer	CCLE	PAPTPTPT	DEG_SCF_FBW7_1	0.1944
p.P587L	ACH-000265	Pancreatic Cancer	CCLE	PAPTPTPT	DEG_SCF_FBW7_1	0.2222
p.P587L	ACH-002046	Endometrial/Uterine Cancer	CCLE	PAPTPTPT	DEG_SCF_FBW7_1	0.2222
p.L583I	ACH-000956	Prostate Cancer	CCLE	PAPTPTPT	DEG_SCF_FBW7_1	0.1111
p.E584D	CW-2	large_intestine	COSMIC	PAPTPTPT	DEG_SCF_FBW7_1	0.5833
p.P589H	HCT-15	large_intestine	COSMIC	PAPTPTPT	DEG_SCF_FBW7_1	0.2778
p.E584K	IM-95	stomach	COSMIC	PAPTPTPT	DEG_SCF_FBW7_1	0.5833

Drug responses associated with MAPK7 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM01086	ALL\|leukemia	p.A653V (No)	GDSC	XMD8-85	2.5514
SIDM01086	ALL\|leukemia	p.A653V (No)	GDSC	BIX02189	15.9036
SIDM01086	ALL\|leukemia	p.A653V (No)	GDSC	XMD8-92	6.4159
SIDM00145	ALL\|lymphoblastic_leukemia	p.R392C (No)	GDSC	XMD8-85	16.8813
SIDM00145	ALL\|lymphoblastic_leukemia	p.R392C (No)	GDSC	BIX02189	9.6793
SIDM00121	ALL\|lymphoblastic_leukemia	p.R534Q (No)	GDSC	XMD8-85	12.4729
SIDM00121	ALL\|lymphoblastic_leukemia	p.R534Q (No)	GDSC	BIX02189	11.5912
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.R499Q (No)	GDSC	XMD8-85	5.1126
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.R499Q (No)	GDSC	BIX02189	5.2807
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.R499Q (No)	GDSC	XMD8-92	7.3732
SIDM00957	COREAD\|large_intestine	p.M805V (No)	GDSC	BIX02189	132.7185
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.S36T (No)	GDSC	XMD8-85	23.7978
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.S36T (No)	GDSC	BIX02189	177.3276
SIDM00798	UNCLASSIFIED\|rhabdomyosarcoma	p.R318H (No)	GDSC	BIX02189	18.7188
SIDM00350	HNSC\|head_and_neck	p.A779D (No)	GDSC	BIX02189	159.2732
SIDM00250	ESCA\|oesophagus	p.E461* (No)	GDSC	BIX02189	194.5539
SIDM00250	ESCA\|oesophagus	p.E461* (No)	GDSC	XMD8-92	93.3736
SIDM00355	LUAD\|lung_NSCLC_adenocarcinoma	p.A296T (No)	GDSC	BIX02189	90.8475
SIDM00355	LUAD\|lung_NSCLC_adenocarcinoma	p.A296T (No)	GDSC	XMD8-92	34.3836
SIDM00777	COREAD\|large_intestine	p.R392C (No)	GDSC	XMD8-92	23.7105
SIDM00052	ESCA\|oesophagus	p.R258Q (No)	GDSC	BIX02189	196.9782
SIDM00220	OV\|ovary	p.R318H (No)	GDSC	BIX02189	55.9195
SIDM00220	OV\|ovary	p.R318H (No)	GDSC	XMD8-92	4.1787
SIDM00154	MESO\|mesothelioma	p.D761N (No)	GDSC	BIX02189	17.1852
SIDM00154	MESO\|mesothelioma	p.D761N (No)	GDSC	XMD8-92	37.4507
SIDM00003	SKCM\|melanoma	p.S517F (No)	GDSC	BIX02189	44.1358
SIDM00901	UCEC\|endometrium	p.P673fs*41 (No)	GDSC	BIX02189	173.9695
SIDM00887	MB\|medulloblastoma	p.I792T (No)	GDSC	BIX02189	59.3632
SIDM00602	STAD\|stomach	p.E723K (No)	GDSC	BIX02189	48.1
SIDM00602	STAD\|stomach	p.E723K (No)	GDSC	XMD8-92	31.2818
SIDM00792	SCLC\|lung_small_cell_carcinoma	p.S247F (No)	GDSC	BIX02189	12.6367
SIDM00792	SCLC\|lung_small_cell_carcinoma	p.S247F (No)	GDSC	XMD8-92	110.6828
SIDM01045	UCEC\|endometrium	p.P361L (No)	GDSC	BIX02189	136.9847
SIDM01045	UCEC\|endometrium	p.P361L (No)	GDSC	XMD8-92	191.0897
SIDM00870	BRCA\|breast	p.M704V (No)	GDSC	BIX02189	115.4215
SIDM00870	BRCA\|breast	p.M704V (No)	GDSC	XMD8-92	144.3246
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.I381V (No)	GDSC	BIX02189	6.6501
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.I381V (No)	GDSC	XMD8-92	29.9785
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.W781C (No)	GDSC	BIX02189	6.6501
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.W781C (No)	GDSC	XMD8-92	29.9785
SIDM00217	COREAD\|large_intestine	p.A334T (No)	GDSC	BIX02189	87.42
SIDM00807	BLCA\|bladder	p.P655L (No)	GDSC	BIX02189	68.6919
SIDM00216	COREAD\|large_intestine	p.A116T (No)	GDSC	BIX02189	28.7273
SIDM00231	KIRC\|kidney	p.D364E (No)	GDSC	XMD8-92	54.3171
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.A621T (No)	GDSC	BIX02189	461.9964
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.A621T (No)	GDSC	XMD8-92	104.0454
SIDM00596	UCEC\|endometrium	p.A653T (No)	GDSC	BIX02189	211.0616
SIDM00596	UCEC\|endometrium	p.A653T (No)	GDSC	XMD8-92	17.0861
SIDM00282	COREAD\|large_intestine	p.A658V (No)	GDSC	XMD8-85	207.8642
SIDM00282	COREAD\|large_intestine	p.A658V (No)	GDSC	BIX02189	248.1206
SIDM00282	COREAD\|large_intestine	p.A658V (No)	GDSC	XMD8-92	133.1721
SIDM00282	COREAD\|large_intestine	p.E723D (No)	GDSC	XMD8-85	207.8642
SIDM00282	COREAD\|large_intestine	p.E723D (No)	GDSC	BIX02189	248.1206
SIDM00282	COREAD\|large_intestine	p.E723D (No)	GDSC	XMD8-92	133.1721
SIDM00613	LGG\|glioma	p.A665T (No)	GDSC	XMD8-85	9.4106
SIDM00613	LGG\|glioma	p.A665T (No)	GDSC	BIX02189	111.5859
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.D387Y (No)	GDSC	BIX02189	335.3628
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.D387Y (No)	GDSC	XMD8-92	152.9073
SIDM01245	ALL\|lymphoblastic_leukemia	p.G622S (No)	GDSC	XMD8-85	27.3945
SIDM01245	ALL\|lymphoblastic_leukemia	p.G622S (No)	GDSC	BIX02189	8.6827
SIDM01245	ALL\|lymphoblastic_leukemia	p.G622S (No)	GDSC	XMD8-92	9.7364
SIDM00789	COREAD\|large_intestine	p.P728H (No)	GDSC	BIX02189	75.1314
SIDM00789	COREAD\|large_intestine	p.P728H (No)	GDSC	XMD8-92	107.9694
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.K104N (No)	GDSC	XMD8-85	174.8914
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.K104N (No)	GDSC	BIX02189	841.6624
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.K104N (No)	GDSC	XMD8-92	50.9333
SIDM00487	COREAD\|large_intestine	p.A296T (No)	GDSC	BIX02189	75.7209
SIDM00487	COREAD\|large_intestine	p.A296T (No)	GDSC	XMD8-92	11.7534
SIDM00368	SCLC\|lung_small_cell_carcinoma	p.A296T (No)	GDSC	BIX02189	87.1593
SIDM00217	COREAD\|large_intestine	p.G698fs*16 (No)	GDSC	BIX02189	87.42
SIDM00120	PRAD\|prostate	p.S718F (No)	GDSC	BIX02189	110.6916
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.E292G (No)	GDSC	BIX02189	104.7845
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.G78S (No)	GDSC	XMD8-85	1.7728
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.G78S (No)	GDSC	BIX02189	19.1502
SIDM00225	SKCM\|melanoma	p.A478S (No)	GDSC	XMD8-85	8.0891
SIDM00225	SKCM\|melanoma	p.A478S (No)	GDSC	BIX02189	102.7849
SIDM00225	SKCM\|melanoma	p.A478S (No)	GDSC	XMD8-92	35.2654
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.D447N (No)	GDSC	XMD8-85	16.5629
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.D447N (No)	GDSC	BIX02189	55.2672
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.D447N (No)	GDSC	XMD8-92	6.7988
SIDM00373	UCEC\|endometrium	p.L669F (No)	GDSC	BIX02189	38.0644
SIDM00373	UCEC\|endometrium	p.L669F (No)	GDSC	XMD8-92	5.7734
SIDM00364	ALL\|lymphoblastic_leukemia	p.G674fs*36 (No)	GDSC	XMD8-85	18.2565
SIDM00364	ALL\|lymphoblastic_leukemia	p.G674fs*36 (No)	GDSC	BIX02189	6.9481
SIDM00968	OV\|ovary	p.S36T (No)	GDSC	BIX02189	45.9423
SIDM00968	OV\|ovary	p.S36T (No)	GDSC	XMD8-92	16.407

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PAPTPTPT

Degron related mutations and impact score

Drug responses associated with MAPK7 mutations

All proteins holding degron of PAPTPTPT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13164	Mitogen-activated protein kinase 7	DEG_SCF_FBW7_1	591:598	PAPTPTPT	FBXW7	0.9857	More...