DegronMD

Uniprot ID: Q13164

Source protein: Mitogen-activated protein kinase 7

Source gene: MAPK7

Class: DEG_SPOP_SBC_1

Location: 621:625

E3 ligase: SPOP

DEGRON score: 0.9979

ASA_SCORE: 72.42

COIL: 0.945

CONS_SCORE: 0.3676

DSS_SCORE: 0.8488

HELIX: 0.025

FCONS_SCORE: 1.1818

RIG_SCORE: 0.4328

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A632V	TCGA-D1-A17Q	UCEC	TCGA	AGSTS	DEG_SPOP_SBC_1	0.1389
p.A632V	DO41903	UCEC	ICGC	AGSTS	DEG_SPOP_SBC_1	0.1389
p.P634L	DO222309	DLBC	ICGC	AGSTS	DEG_SPOP_SBC_1	0.0833
p.P635T	DO50662	ORCA	ICGC	AGSTS	DEG_SPOP_SBC_1	0.0556
p.G622S	SIDM01245	T-Lymphoblastic Leukemia	GDSC	AGSTS	DEG_SPOP_SBC_1	0.5882
p.G622S	SIDM00991	T-Lymphoblastic Leukemia	GDSC	AGSTS	DEG_SPOP_SBC_1	0.5882
p.G622S	ACH-000519	Leukemia	CCLE	AGSTS	DEG_SPOP_SBC_1	0.5882
p.G622S	ACH-002216	Leukemia	CCLE	AGSTS	DEG_SPOP_SBC_1	0.5882
p.G622S	BE-13	haematopoietic_and_lymphoid_tissue	COSMIC	AGSTS	DEG_SPOP_SBC_1	0.5882
p.A621T	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	AGSTS	DEG_SPOP_SBC_1	0.7139
p.A621T	ACH-001137	Lung Cancer	CCLE	AGSTS	DEG_SPOP_SBC_1	0.7139
p.A621T	NCI-H1993	lung	COSMIC	AGSTS	DEG_SPOP_SBC_1	0.7139
p.D622N	H2795	pleura	COSMIC	AGSTS	DEG_SPOP_SBC_1	0.6932

Drug responses associated with MAPK7 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM01086	ALL\|leukemia	p.A653V (No)	GDSC	XMD8-85	2.5514
SIDM01086	ALL\|leukemia	p.A653V (No)	GDSC	BIX02189	15.9036
SIDM01086	ALL\|leukemia	p.A653V (No)	GDSC	XMD8-92	6.4159
SIDM00145	ALL\|lymphoblastic_leukemia	p.R392C (No)	GDSC	XMD8-85	16.8813
SIDM00145	ALL\|lymphoblastic_leukemia	p.R392C (No)	GDSC	BIX02189	9.6793
SIDM00121	ALL\|lymphoblastic_leukemia	p.R534Q (No)	GDSC	XMD8-85	12.4729
SIDM00121	ALL\|lymphoblastic_leukemia	p.R534Q (No)	GDSC	BIX02189	11.5912
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.R499Q (No)	GDSC	XMD8-85	5.1126
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.R499Q (No)	GDSC	BIX02189	5.2807
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.R499Q (No)	GDSC	XMD8-92	7.3732
SIDM00957	COREAD\|large_intestine	p.M805V (No)	GDSC	BIX02189	132.7185
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.S36T (No)	GDSC	XMD8-85	23.7978
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.S36T (No)	GDSC	BIX02189	177.3276
SIDM00798	UNCLASSIFIED\|rhabdomyosarcoma	p.R318H (No)	GDSC	BIX02189	18.7188
SIDM00350	HNSC\|head_and_neck	p.A779D (No)	GDSC	BIX02189	159.2732
SIDM00250	ESCA\|oesophagus	p.E461* (No)	GDSC	BIX02189	194.5539
SIDM00250	ESCA\|oesophagus	p.E461* (No)	GDSC	XMD8-92	93.3736
SIDM00355	LUAD\|lung_NSCLC_adenocarcinoma	p.A296T (No)	GDSC	BIX02189	90.8475
SIDM00355	LUAD\|lung_NSCLC_adenocarcinoma	p.A296T (No)	GDSC	XMD8-92	34.3836
SIDM00777	COREAD\|large_intestine	p.R392C (No)	GDSC	XMD8-92	23.7105
SIDM00052	ESCA\|oesophagus	p.R258Q (No)	GDSC	BIX02189	196.9782
SIDM00220	OV\|ovary	p.R318H (No)	GDSC	BIX02189	55.9195
SIDM00220	OV\|ovary	p.R318H (No)	GDSC	XMD8-92	4.1787
SIDM00154	MESO\|mesothelioma	p.D761N (No)	GDSC	BIX02189	17.1852
SIDM00154	MESO\|mesothelioma	p.D761N (No)	GDSC	XMD8-92	37.4507
SIDM00003	SKCM\|melanoma	p.S517F (No)	GDSC	BIX02189	44.1358
SIDM00901	UCEC\|endometrium	p.P673fs*41 (No)	GDSC	BIX02189	173.9695
SIDM00887	MB\|medulloblastoma	p.I792T (No)	GDSC	BIX02189	59.3632
SIDM00602	STAD\|stomach	p.E723K (No)	GDSC	BIX02189	48.1
SIDM00602	STAD\|stomach	p.E723K (No)	GDSC	XMD8-92	31.2818
SIDM00792	SCLC\|lung_small_cell_carcinoma	p.S247F (No)	GDSC	BIX02189	12.6367
SIDM00792	SCLC\|lung_small_cell_carcinoma	p.S247F (No)	GDSC	XMD8-92	110.6828
SIDM01045	UCEC\|endometrium	p.P361L (No)	GDSC	BIX02189	136.9847
SIDM01045	UCEC\|endometrium	p.P361L (No)	GDSC	XMD8-92	191.0897
SIDM00870	BRCA\|breast	p.M704V (No)	GDSC	BIX02189	115.4215
SIDM00870	BRCA\|breast	p.M704V (No)	GDSC	XMD8-92	144.3246
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.I381V (No)	GDSC	BIX02189	6.6501
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.I381V (No)	GDSC	XMD8-92	29.9785
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.W781C (No)	GDSC	BIX02189	6.6501
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.W781C (No)	GDSC	XMD8-92	29.9785
SIDM00217	COREAD\|large_intestine	p.A334T (No)	GDSC	BIX02189	87.42
SIDM00807	BLCA\|bladder	p.P655L (No)	GDSC	BIX02189	68.6919
SIDM00216	COREAD\|large_intestine	p.A116T (No)	GDSC	BIX02189	28.7273
SIDM00231	KIRC\|kidney	p.D364E (No)	GDSC	XMD8-92	54.3171
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.A621T (Yes)	GDSC	BIX02189	461.9964
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.A621T (Yes)	GDSC	XMD8-92	104.0454
SIDM00596	UCEC\|endometrium	p.A653T (No)	GDSC	BIX02189	211.0616
SIDM00596	UCEC\|endometrium	p.A653T (No)	GDSC	XMD8-92	17.0861
SIDM00282	COREAD\|large_intestine	p.A658V (No)	GDSC	XMD8-85	207.8642
SIDM00282	COREAD\|large_intestine	p.A658V (No)	GDSC	BIX02189	248.1206
SIDM00282	COREAD\|large_intestine	p.A658V (No)	GDSC	XMD8-92	133.1721
SIDM00282	COREAD\|large_intestine	p.E723D (No)	GDSC	XMD8-85	207.8642
SIDM00282	COREAD\|large_intestine	p.E723D (No)	GDSC	BIX02189	248.1206
SIDM00282	COREAD\|large_intestine	p.E723D (No)	GDSC	XMD8-92	133.1721
SIDM00613	LGG\|glioma	p.A665T (No)	GDSC	XMD8-85	9.4106
SIDM00613	LGG\|glioma	p.A665T (No)	GDSC	BIX02189	111.5859
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.D387Y (No)	GDSC	BIX02189	335.3628
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.D387Y (No)	GDSC	XMD8-92	152.9073
SIDM01245	ALL\|lymphoblastic_leukemia	p.G622S (Yes)	GDSC	XMD8-85	27.3945
SIDM01245	ALL\|lymphoblastic_leukemia	p.G622S (Yes)	GDSC	BIX02189	8.6827
SIDM01245	ALL\|lymphoblastic_leukemia	p.G622S (Yes)	GDSC	XMD8-92	9.7364
SIDM00789	COREAD\|large_intestine	p.P728H (No)	GDSC	BIX02189	75.1314
SIDM00789	COREAD\|large_intestine	p.P728H (No)	GDSC	XMD8-92	107.9694
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.K104N (No)	GDSC	XMD8-85	174.8914
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.K104N (No)	GDSC	BIX02189	841.6624
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.K104N (No)	GDSC	XMD8-92	50.9333
SIDM00487	COREAD\|large_intestine	p.A296T (No)	GDSC	BIX02189	75.7209
SIDM00487	COREAD\|large_intestine	p.A296T (No)	GDSC	XMD8-92	11.7534
SIDM00368	SCLC\|lung_small_cell_carcinoma	p.A296T (No)	GDSC	BIX02189	87.1593
SIDM00217	COREAD\|large_intestine	p.G698fs*16 (No)	GDSC	BIX02189	87.42
SIDM00120	PRAD\|prostate	p.S718F (No)	GDSC	BIX02189	110.6916
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.E292G (No)	GDSC	BIX02189	104.7845
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.G78S (No)	GDSC	XMD8-85	1.7728
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.G78S (No)	GDSC	BIX02189	19.1502
SIDM00225	SKCM\|melanoma	p.A478S (No)	GDSC	XMD8-85	8.0891
SIDM00225	SKCM\|melanoma	p.A478S (No)	GDSC	BIX02189	102.7849
SIDM00225	SKCM\|melanoma	p.A478S (No)	GDSC	XMD8-92	35.2654
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.D447N (No)	GDSC	XMD8-85	16.5629
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.D447N (No)	GDSC	BIX02189	55.2672
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.D447N (No)	GDSC	XMD8-92	6.7988
SIDM00373	UCEC\|endometrium	p.L669F (No)	GDSC	BIX02189	38.0644
SIDM00373	UCEC\|endometrium	p.L669F (No)	GDSC	XMD8-92	5.7734
SIDM00364	ALL\|lymphoblastic_leukemia	p.G674fs*36 (No)	GDSC	XMD8-85	18.2565
SIDM00364	ALL\|lymphoblastic_leukemia	p.G674fs*36 (No)	GDSC	BIX02189	6.9481
SIDM00968	OV\|ovary	p.S36T (No)	GDSC	BIX02189	45.9423
SIDM00968	OV\|ovary	p.S36T (No)	GDSC	XMD8-92	16.407

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00567	Nucleolar protein 56	DEG_SPOP_SBC_1	526:530	AGSTS	SPOP	0.9464	More...
O15027	Protein transport protein Sec16A	DEG_SPOP_SBC_1	959:963	AGSTS	SPOP	0.9989	More...
O76080	AN1-type zinc finger protein 5	DEG_SPOP_SBC_1	80:84	AGSTS	SPOP	0.9883	More...
P03372	Estrogen receptor	DEG_SPOP_SBC_1	571:575	AGSTS	SPOP	0.9845	More...
P15923	Transcription factor E2-alpha	DEG_SPOP_SBC_1	453:457	AGSTS	SPOP	0.9279	More...
Q13164	Mitogen-activated protein kinase 7	DEG_SPOP_SBC_1	621:625	AGSTS	SPOP	0.9979	More...
Q14186	Transcription factor Dp-1	DEG_SPOP_SBC_1	350:354	AGSTS	SPOP	0.9899	More...
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_SPOP_SBC_1	778:782	AGSTS	SPOP	0.7948	More...
Q96JN0	Ligand-dependent corepressor	DEG_SPOP_SBC_1	93:97	AGSTS	SPOP	0.9806	More...
Q99570	Phosphoinositide 3-kinase regulatory subunit 4	DEG_SPOP_SBC_1	1280:1284	AGSTS	SPOP	0.8593	More...
Q9BXF6	Rab11 family-interacting protein 5	DEG_SPOP_SBC_1	38:42	AGSTS	SPOP	0.7413	More...
Q9NQV8	PR domain zinc finger protein 8	DEG_SPOP_SBC_1	469:473	AGSTS	SPOP	0.9917	More...
Q9NW13	RNA-binding protein 28	DEG_SPOP_SBC_1	642:646	AGSTS	SPOP	0.9698	More...
Q9Y466	Nuclear receptor subfamily 2 group E member 1	DEG_SPOP_SBC_1	5:9	AGSTS	SPOP	0.7921	More...
Q9Y5Q3	Transcription factor MafB	DEG_SPOP_SBC_1	309:313	AGSTS	SPOP	0.9235	More...
Q86XD8	AN1-type zinc finger protein 4	DEG_SPOP_SBC_1	574:578	AGSTS	SPOP	0.9676	More...
Q8IYL3	UPF0688 protein C1orf174	DEG_SPOP_SBC_1	33:37	AGSTS	SPOP	0.9615	More...
Q86X59	Putative uncharacterized protein LINC02875	DEG_SPOP_SBC_1	166:170	AGSTS	SPOP	0.9773	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AGSTS

Degron related mutations and impact score

Drug responses associated with MAPK7 mutations

All proteins holding degron of AGSTS