DegronMD - Q99570(PIK3R4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I921L	TCGA-AN-A046	BRCA	TCGA	STSSQVPEV	DEG_COP1_1	903:911	Mutation rewiring degron network	0.0556
p.I921L	DO1285	BRCA	ICGC	STSSQVPEV	DEG_COP1_1	903:911	Mutation rewiring degron network	0.0556
p.V920L	TCGA-AX-A2HJ	UCEC	TCGA	STSSQVPEV	DEG_COP1_1	903:911	Mutation rewiring degron network	0.0833
p.V920L	DO42105	UCEC	ICGC	STSSQVPEV	DEG_COP1_1	903:911	Mutation rewiring degron network	0.0833
p.V1279I	TCGA-C5-A1MN	CESC	TCGA	AGSTS	DEG_SPOP_SBC_1	1280:1284	Mutation rewiring degron network	0.3056
p.V1279I	DO6257	CESC	ICGC	AGSTS	DEG_SPOP_SBC_1	1280:1284	Mutation rewiring degron network	0.3056
p.P919T	TCGA-D1-A16X	UCEC	TCGA	STSSQVPEV	DEG_COP1_1	903:911	Mutation rewiring degron network	0.1111
p.P919T	DO41799	UCEC	ICGC	STSSQVPEV	DEG_COP1_1	903:911	Mutation rewiring degron network	0.1111
p.Q915K	TCGA-DA-A1IB	SKCM	TCGA	STSSQVPEV	DEG_COP1_1	903:911	Mutation rewiring degron network	0.2222
p.Q915K	TCGA-DA-A1IB	SKCM	TCGA	PLSTS	DEG_SPOP_SBC_1	901:905	Mutation rewiring degron network	0.0556
p.Q915K	DO38033	SKCM	ICGC	STSSQVPEV	DEG_COP1_1	903:911	Mutation rewiring degron network	0.2222
p.Q915K	DO38033	SKCM	ICGC	PLSTS	DEG_SPOP_SBC_1	901:905	Mutation rewiring degron network	0.0556
p.T913P	TCGA-FU-A3HZ	CESC	TCGA	STSSQVPEV	DEG_COP1_1	903:911	Mutation rewiring degron network	0.2778
p.T913P	TCGA-FU-A3HZ	CESC	TCGA	PLSTS	DEG_SPOP_SBC_1	901:905	Mutation rewiring degron network	0.1111
p.T913P	DO6308	CESC	ICGC	STSSQVPEV	DEG_COP1_1	903:911	Mutation rewiring degron network	0.2778
p.T913P	DO6308	CESC	ICGC	PLSTS	DEG_SPOP_SBC_1	901:905	Mutation rewiring degron network	0.1111
p.S906L	TCGA-VS-A9U6	CESC	TCGA	STSSQVPEV	DEG_COP1_1	903:911	Mutation altering degron motif	0.6556
p.S906L	DO219728	CESC	ICGC	STSSQVPEV	DEG_COP1_1	903:911	Mutation altering degron motif	0.6556
p.K918N	TCGA-XK-AAIW	PRAD	TCGA	STSSQVPEV	DEG_COP1_1	903:911	Mutation blocking ubiquitination signal	0.5833
p.K918N	DO51407	PRAD	ICGC	STSSQVPEV	DEG_COP1_1	903:911	Mutation blocking ubiquitination signal	0.5833
p.A1280T	DO233871	GACA	ICGC	AGSTS	DEG_SPOP_SBC_1	1280:1284	Mutation altering degron motif	0.7139
p.S1289F	DO233925	GACA	ICGC	AGSTS	DEG_SPOP_SBC_1	1280:1284	Mutation blocking phosphorylation signal	0.6389
p.E910K	DO231959	LICA	ICGC	STSSQVPEV	DEG_COP1_1	903:911	Mutation altering degron motif	0.7022
p.T912K	DO228978	LICA	ICGC	STSSQVPEV	DEG_COP1_1	903:911	Mutation rewiring degron network	0.3056
p.T912K	DO228978	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	901:905	Mutation rewiring degron network	0.1389
p.P1273S	DO229054	LICA	ICGC	AGSTS	DEG_SPOP_SBC_1	1280:1284	Mutation rewiring degron network	0.1389
p.Y1277C	DO48689	LIRI	ICGC	AGSTS	DEG_SPOP_SBC_1	1280:1284	Mutation rewiring degron network	0.25
p.L1270S	DO220910	MELA	ICGC	AGSTS	DEG_SPOP_SBC_1	1280:1284	Mutation rewiring degron network	0.0556
p.E893K	SIDM00689	B-Lymphoblastic Leukemia	GDSC	STSSQVPEV	DEG_COP1_1	903:911	Mutation rewiring degron network	0.0556
p.E893K	SIDM00689	B-Lymphoblastic Leukemia	GDSC	PLSTS	DEG_SPOP_SBC_1	901:905	Mutation rewiring degron network	0.1111
p.E893K	ACH-000151	Leukemia	CCLE	STSSQVPEV	DEG_COP1_1	903:911	Mutation rewiring degron network	0.0556
p.E893K	ACH-000151	Leukemia	CCLE	PLSTS	DEG_SPOP_SBC_1	901:905	Mutation rewiring degron network	0.1111
p.E893K	JM1	haematopoietic and lymphoid tissue	COSMIC	STSSQVPEV	DEG_COP1_1	903:911	Mutation rewiring degron network	0.0556
p.E893K	JM1	haematopoietic and lymphoid tissue	COSMIC	PLSTS	DEG_SPOP_SBC_1	901:905	Mutation rewiring degron network	0.1111
p.S892F	SIDM00920	Breast Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	901:905	Mutation blocking phosphorylation signal	0.5278
p.S892F	ACH-000783	Breast Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	901:905	Mutation blocking phosphorylation signal	0.5278
p.S892F	CAMA-1	breast	COSMIC	PLSTS	DEG_SPOP_SBC_1	901:905	Mutation blocking phosphorylation signal	0.5278
p.P919Q	SIDM01619	Endometrial Carcinoma	GDSC	STSSQVPEV	DEG_COP1_1	903:911	Mutation rewiring degron network	0.1111
p.P919Q	ACH-000984	Endometrial/Uterine Cancer	CCLE	STSSQVPEV	DEG_COP1_1	903:911	Mutation rewiring degron network	0.1111

Kaplan plot for PIK3R4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PIK3R4

UniProt ID: Q99570

Entrez ID: 30849

Protein name: Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PIK3R4 in