DegronMD

Uniprot ID: Q99570

Source protein: Phosphoinositide 3-kinase regulatory subunit 4

Source gene: PIK3R4

Class: DEG_COP1_1

Location: 903:911

E3 ligase: COP1

DEGRON score: 0.9934

ASA_SCORE: 72.7

COIL: 0.6984

CONS_SCORE: 0.2311

DSS_SCORE: 0.4044

HELIX: 0.0521

FCONS_SCORE: 1.0152

RIG_SCORE: 0.7022

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I921L	TCGA-AN-A046	BRCA	TCGA	STSSQVPEV	DEG_COP1_1	0.0556
p.I921L	DO1285	BRCA	ICGC	STSSQVPEV	DEG_COP1_1	0.0556
p.V920L	TCGA-AX-A2HJ	UCEC	TCGA	STSSQVPEV	DEG_COP1_1	0.0833
p.V920L	DO42105	UCEC	ICGC	STSSQVPEV	DEG_COP1_1	0.0833
p.P919T	TCGA-D1-A16X	UCEC	TCGA	STSSQVPEV	DEG_COP1_1	0.1111
p.P919T	DO41799	UCEC	ICGC	STSSQVPEV	DEG_COP1_1	0.1111
p.Q915K	TCGA-DA-A1IB	SKCM	TCGA	STSSQVPEV	DEG_COP1_1	0.2222
p.Q915K	DO38033	SKCM	ICGC	STSSQVPEV	DEG_COP1_1	0.2222
p.T913P	TCGA-FU-A3HZ	CESC	TCGA	STSSQVPEV	DEG_COP1_1	0.2778
p.T913P	DO6308	CESC	ICGC	STSSQVPEV	DEG_COP1_1	0.2778
p.S906L	TCGA-VS-A9U6	CESC	TCGA	STSSQVPEV	DEG_COP1_1	0.6556
p.S906L	DO219728	CESC	ICGC	STSSQVPEV	DEG_COP1_1	0.6556
p.K918N	TCGA-XK-AAIW	PRAD	TCGA	STSSQVPEV	DEG_COP1_1	0.5833
p.K918N	DO51407	PRAD	ICGC	STSSQVPEV	DEG_COP1_1	0.5833
p.E910K	DO231959	LICA	ICGC	STSSQVPEV	DEG_COP1_1	0.7022
p.T912K	DO228978	LICA	ICGC	STSSQVPEV	DEG_COP1_1	0.3056
p.E893K	SIDM00689	B-Lymphoblastic Leukemia	GDSC	STSSQVPEV	DEG_COP1_1	0.0556
p.E893K	ACH-000151	Leukemia	CCLE	STSSQVPEV	DEG_COP1_1	0.0556
p.E893K	JM1	haematopoietic_and_lymphoid_tissue	COSMIC	STSSQVPEV	DEG_COP1_1	0.0556
p.P919Q	SIDM01619	Endometrial Carcinoma	GDSC	STSSQVPEV	DEG_COP1_1	0.1111
p.P919Q	ACH-000984	Endometrial/Uterine Cancer	CCLE	STSSQVPEV	DEG_COP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99570	Phosphoinositide 3-kinase regulatory subunit 4	DEG_COP1_1	903:911	STSSQVPEV	COP1	0.9934	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons