DegronMD - P15923(TCF3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G451D	TCGA-2W-A8YY	CESC	TCGA	AGSTS	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.2778
p.G451D	DO223732	CESC	ICGC	AGSTS	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.2778
p.M459T	TCGA-D7-A6EY	STAD	TCGA	AGSTS	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.2778
p.M459T	DO50118	STAD	ICGC	AGSTS	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.2778
p.A453T	TCGA-W3-A824	SKCM	TCGA	AGSTS	DEG_SPOP_SBC_1	453:457	Mutation altering degron motif	0.7139
p.A453T	DO51271	SKCM	ICGC	AGSTS	DEG_SPOP_SBC_1	453:457	Mutation altering degron motif	0.7139
p.A453T	SIDM00660	Colorectal Carcinoma	GDSC	AGSTS	DEG_SPOP_SBC_1	453:457	Mutation altering degron motif	0.7139
p.A453T	SIDM00542	Glioblastoma	GDSC	AGSTS	DEG_SPOP_SBC_1	453:457	Mutation altering degron motif	0.7139
p.A453T	D-392MG	central nervous system	COSMIC	AGSTS	DEG_SPOP_SBC_1	453:457	Mutation altering degron motif	0.7139
p.A453T	LS-411N	large intestine	COSMIC	AGSTS	DEG_SPOP_SBC_1	453:457	Mutation altering degron motif	0.7139
p.H460Y	DO49357	ALL	ICGC	AGSTS	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.25
p.S359C	DO218535	BTCA	ICGC	PSTPVGS	DEG_SCF_FBW7_1	353:359	Mutation altering degron motif	0.8652
p.R458M	DO20082	KIRC	ICGC	AGSTS	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.3056
p.S457R	DO229031	LICA	ICGC	AGSTS	DEG_SPOP_SBC_1	453:457	Mutation altering degron motif	0.7427
p.L465I	DO229035	LICA	ICGC	AGSTS	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.1111
p.A463E	DO229037	LICA	ICGC	AGSTS	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.1667
p.S359F	DO23356	LINC	ICGC	PSTPVGS	DEG_SCF_FBW7_1	353:359	Mutation altering degron motif	0.9093
p.P448S	SIDM02014	Esophageal Carcinoma	GDSC	AGSTS	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.1944
p.G362D	SIDM01104	Melanoma	GDSC	PSTPVGS	DEG_SCF_FBW7_1	353:359	Mutation rewiring degron network	0.25
p.G362D	SIDM01111	Ewing's Sarcoma	GDSC	PSTPVGS	DEG_SCF_FBW7_1	353:359	Mutation rewiring degron network	0.25
p.G451S	SIDM00938	Breast Carcinoma	GDSC	AGSTS	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.2778
p.G451S	CAL-148	breast	COSMIC	AGSTS	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.2778
p.S345L	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PSTPVGS	DEG_SCF_FBW7_1	353:359	Mutation blocking phosphorylation signal	0.5556
p.S345L	ACH-000995	Leukemia	CCLE	PSTPVGS	DEG_SCF_FBW7_1	353:359	Mutation blocking phosphorylation signal	0.5556
p.S345L	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	353:359	Mutation blocking phosphorylation signal	0.5556
p.P353L	ACH-001192	Bone Cancer	CCLE	PSTPVGS	DEG_SCF_FBW7_1	353:359	Mutation altering degron motif	0.6471
p.G454D	ACH-002069	Bone Cancer	CCLE	AGSTS	DEG_SPOP_SBC_1	453:457	Mutation altering degron motif	0.6087
p.T457M	RPMI-8226	haematopoietic and lymphoid tissue	COSMIC	AGSTS	DEG_SPOP_SBC_1	453:457	Mutation altering degron motif	0.7423
p.T457M	SNU-1040	large intestine	COSMIC	AGSTS	DEG_SPOP_SBC_1	453:457	Mutation altering degron motif	0.7423
p.G466R	JVM-2	haematopoietic and lymphoid tissue	COSMIC	AGSTS	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.0833
p.D344N	TE-8	oesophagus	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	353:359	Mutation rewiring degron network	0.0833

Kaplan plot for TCF3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TCF3

UniProt ID: P15923

Entrez ID: 6929

Protein name: Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TCF3 in