DegronMD

Uniprot ID: P15923

Source protein: Transcription factor E2-alpha

Source gene: TCF3

Class: DEG_SPOP_SBC_1

Location: 453:457

E3 ligase: SPOP

DEGRON score: 0.9279

ASA_SCORE: 59.72

COIL: 0.7934

CONS_SCORE: 0.3866

DSS_SCORE: 0.6174

HELIX: 0.1444

FCONS_SCORE: 0.9906

RIG_SCORE: 0.6009

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G451D	TCGA-2W-A8YY	CESC	TCGA	AGSTS	DEG_SPOP_SBC_1	0.2778
p.G451D	DO223732	CESC	ICGC	AGSTS	DEG_SPOP_SBC_1	0.2778
p.M459T	TCGA-D7-A6EY	STAD	TCGA	AGSTS	DEG_SPOP_SBC_1	0.2778
p.M459T	DO50118	STAD	ICGC	AGSTS	DEG_SPOP_SBC_1	0.2778
p.A453T	TCGA-W3-A824	SKCM	TCGA	AGSTS	DEG_SPOP_SBC_1	0.7139
p.A453T	DO51271	SKCM	ICGC	AGSTS	DEG_SPOP_SBC_1	0.7139
p.A453T	SIDM00660	Colorectal Carcinoma	GDSC	AGSTS	DEG_SPOP_SBC_1	0.7139
p.A453T	SIDM00542	Glioblastoma	GDSC	AGSTS	DEG_SPOP_SBC_1	0.7139
p.A453T	D-392MG	central_nervous_system	COSMIC	AGSTS	DEG_SPOP_SBC_1	0.7139
p.A453T	LS-411N	large_intestine	COSMIC	AGSTS	DEG_SPOP_SBC_1	0.7139
p.H460Y	DO49357	ALL	ICGC	AGSTS	DEG_SPOP_SBC_1	0.25
p.R458M	DO20082	KIRC	ICGC	AGSTS	DEG_SPOP_SBC_1	0.3056
p.S457R	DO229031	LICA	ICGC	AGSTS	DEG_SPOP_SBC_1	0.7427
p.L465I	DO229035	LICA	ICGC	AGSTS	DEG_SPOP_SBC_1	0.1111
p.A463E	DO229037	LICA	ICGC	AGSTS	DEG_SPOP_SBC_1	0.1667
p.P448S	SIDM02014	Esophageal Carcinoma	GDSC	AGSTS	DEG_SPOP_SBC_1	0.1944
p.G451S	SIDM00938	Breast Carcinoma	GDSC	AGSTS	DEG_SPOP_SBC_1	0.2778
p.G451S	CAL-148	breast	COSMIC	AGSTS	DEG_SPOP_SBC_1	0.2778
p.G454D	ACH-002069	Bone Cancer	CCLE	AGSTS	DEG_SPOP_SBC_1	0.6087
p.T457M	RPMI-8226	haematopoietic_and_lymphoid_tissue	COSMIC	AGSTS	DEG_SPOP_SBC_1	0.7423
p.T457M	SNU-1040	large_intestine	COSMIC	AGSTS	DEG_SPOP_SBC_1	0.7423
p.G466R	JVM-2	haematopoietic_and_lymphoid_tissue	COSMIC	AGSTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00567	Nucleolar protein 56	DEG_SPOP_SBC_1	526:530	AGSTS	SPOP	0.9464	More...
O15027	Protein transport protein Sec16A	DEG_SPOP_SBC_1	959:963	AGSTS	SPOP	0.9989	More...
O76080	AN1-type zinc finger protein 5	DEG_SPOP_SBC_1	80:84	AGSTS	SPOP	0.9883	More...
P03372	Estrogen receptor	DEG_SPOP_SBC_1	571:575	AGSTS	SPOP	0.9845	More...
P15923	Transcription factor E2-alpha	DEG_SPOP_SBC_1	453:457	AGSTS	SPOP	0.9279	More...
Q13164	Mitogen-activated protein kinase 7	DEG_SPOP_SBC_1	621:625	AGSTS	SPOP	0.9979	More...
Q14186	Transcription factor Dp-1	DEG_SPOP_SBC_1	350:354	AGSTS	SPOP	0.9899	More...
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_SPOP_SBC_1	778:782	AGSTS	SPOP	0.7948	More...
Q96JN0	Ligand-dependent corepressor	DEG_SPOP_SBC_1	93:97	AGSTS	SPOP	0.9806	More...
Q99570	Phosphoinositide 3-kinase regulatory subunit 4	DEG_SPOP_SBC_1	1280:1284	AGSTS	SPOP	0.8593	More...
Q9BXF6	Rab11 family-interacting protein 5	DEG_SPOP_SBC_1	38:42	AGSTS	SPOP	0.7413	More...
Q9NQV8	PR domain zinc finger protein 8	DEG_SPOP_SBC_1	469:473	AGSTS	SPOP	0.9917	More...
Q9NW13	RNA-binding protein 28	DEG_SPOP_SBC_1	642:646	AGSTS	SPOP	0.9698	More...
Q9Y466	Nuclear receptor subfamily 2 group E member 1	DEG_SPOP_SBC_1	5:9	AGSTS	SPOP	0.7921	More...
Q9Y5Q3	Transcription factor MafB	DEG_SPOP_SBC_1	309:313	AGSTS	SPOP	0.9235	More...
Q86XD8	AN1-type zinc finger protein 4	DEG_SPOP_SBC_1	574:578	AGSTS	SPOP	0.9676	More...
Q8IYL3	UPF0688 protein C1orf174	DEG_SPOP_SBC_1	33:37	AGSTS	SPOP	0.9615	More...
Q86X59	Putative uncharacterized protein LINC02875	DEG_SPOP_SBC_1	166:170	AGSTS	SPOP	0.9773	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AGSTS

Degron related mutations and impact score

Drug responses associated with TCF3 mutations

All proteins holding degron of AGSTS