DegronMD - Q86XD8(ZFAND4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S568C	TCGA-77-A5G6	LUSC	TCGA	AGSTS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1667
p.R586C	TCGA-78-7542	LUAD	TCGA	LQSTRGAGR	SCF_FBXL2	582:590	Mutation altering degron motif	0.8301
p.R586C	TCGA-AP-A0LM	UCEC	TCGA	LQSTRGAGR	SCF_FBXL2	582:590	Mutation altering degron motif	0.8301
p.R586C	SIDM00487	Colorectal Carcinoma	GDSC	LQSTRGAGR	SCF_FBXL2	582:590	Mutation altering degron motif	0.8301
p.R586C	ACH-000963	Colon/Colorectal Cancer	CCLE	LQSTRGAGR	SCF_FBXL2	582:590	Mutation altering degron motif	0.8301
p.R586C	CCK-81	large intestine	COSMIC	LQSTRGAGR	SCF_FBXL2	582:590	Mutation altering degron motif	0.8301
p.G589D	TCGA-CG-5726	STAD	TCGA	LQSTRGAGR	SCF_FBXL2	582:590	Mutation altering degron motif	0.6087
p.L582S	TCGA-CJ-6031	KIRC	TCGA	LQSTRGAGR	SCF_FBXL2	582:590	Mutation altering degron motif	0.7667
p.G575R	TCGA-CZ-5461	KIRC	TCGA	AGSTS	DEG_SPOP_SBC_1	574:578	Mutation altering degron motif	0.6457
p.L570P	TCGA-E9-A22B	BRCA	TCGA	AGSTS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.2222
p.P577S	DO51269	SKCM	ICGC	AGSTS	DEG_SPOP_SBC_1	574:578	Mutation altering degron motif	0.6752
p.R586G	SIDM00971	Breast Carcinoma	GDSC	LQSTRGAGR	SCF_FBXL2	582:590	Mutation altering degron motif	0.7568
p.R586G	SIDM00785	Acute Myeloid Leukemia	GDSC	LQSTRGAGR	SCF_FBXL2	582:590	Mutation altering degron motif	0.7568
p.T590A	DJM-1	skin	COSMIC	LQSTRGAGR	SCF_FBXL2	582:590	Mutation altering degron motif	0.7139
p.T590A	KMS-11	haematopoietic and lymphoid tissue	COSMIC	LQSTRGAGR	SCF_FBXL2	582:590	Mutation altering degron motif	0.7139
p.K588E	SW156	kidney	COSMIC	LQSTRGAGR	SCF_FBXL2	582:590	Mutation altering degron motif	0.7022

Kaplan plot for ZFAND4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZFAND4

UniProt ID: Q86XD8

Entrez ID: 93550

Protein name: AN1-type zinc finger protein 4 (AN1-type zinc finger and ubiquitin domain-containing protein-like 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZFAND4 in