DegronMD

Uniprot ID: Q86XD8

Source protein: AN1-type zinc finger protein 4

Source gene: ZFAND4

Class: SCF_FBXL2

Location: 582:590

E3 ligase: FBXL2

DEGRON score: 0.6851

ASA_SCORE: 73.7778

COIL: 0.6921

CONS_SCORE: 0.5621

DSS_SCORE: 0.6099

HELIX: 0.209

FCONS_SCORE: 0.9886

RIG_SCORE: 0.6728

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R586C	TCGA-78-7542	LUAD	TCGA	LQSTRGAGR	SCF_FBXL2	0.8301
p.R586C	TCGA-AP-A0LM	UCEC	TCGA	LQSTRGAGR	SCF_FBXL2	0.8301
p.R586C	SIDM00487	Colorectal Carcinoma	GDSC	LQSTRGAGR	SCF_FBXL2	0.8301
p.R586C	ACH-000963	Colon/Colorectal Cancer	CCLE	LQSTRGAGR	SCF_FBXL2	0.8301
p.R586C	CCK-81	large_intestine	COSMIC	LQSTRGAGR	SCF_FBXL2	0.8301
p.G589D	TCGA-CG-5726	STAD	TCGA	LQSTRGAGR	SCF_FBXL2	0.6087
p.L582S	TCGA-CJ-6031	KIRC	TCGA	LQSTRGAGR	SCF_FBXL2	0.7667
p.R586G	SIDM00971	Breast Carcinoma	GDSC	LQSTRGAGR	SCF_FBXL2	0.7568
p.R586G	SIDM00785	Acute Myeloid Leukemia	GDSC	LQSTRGAGR	SCF_FBXL2	0.7568
p.T590A	DJM-1	skin	COSMIC	LQSTRGAGR	SCF_FBXL2	0.7139
p.T590A	KMS-11	haematopoietic_and_lymphoid_tissue	COSMIC	LQSTRGAGR	SCF_FBXL2	0.7139
p.K588E	SW156	kidney	COSMIC	LQSTRGAGR	SCF_FBXL2	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86XD8	AN1-type zinc finger protein 4	SCF_FBXL2	582:590	LQSTRGAGR	FBXL2	0.6851	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons