DegronMD - Q9NW13(RBM28)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R365S	TCGA-09-2044	OV	TCGA	RIVLHPD	LIG_APCC_ABBAyCdc20_2	365:371	Mutation altering degron motif	0.7427
p.R365S	DO28923	OV	ICGC	RIVLHPD	LIG_APCC_ABBAyCdc20_2	365:371	Mutation altering degron motif	0.7427
p.Y363D	TCGA-20-0987	OV	TCGA	IVLHPD	LIG_APCC_ABBA_1	366:371	Mutation rewiring degron network	0.25
p.Y363D	TCGA-20-0987	OV	TCGA	RIVLHPD	LIG_APCC_ABBAyCdc20_2	365:371	Mutation rewiring degron network	0.2778
p.Y363D	DO31210	OV	ICGC	IVLHPD	LIG_APCC_ABBA_1	366:371	Mutation rewiring degron network	0.25
p.Y363D	DO31210	OV	ICGC	RIVLHPD	LIG_APCC_ABBAyCdc20_2	365:371	Mutation rewiring degron network	0.2778
p.K501R	TCGA-94-A5I4	LUSC	TCGA	TRLCLHNLP	DEG_APCC_DBOX_1	487:495	Mutation substituting flanking lysine	0.2778
p.K501R	DO219175	LUSC	ICGC	TRLCLHNLP	DEG_APCC_DBOX_1	487:495	Mutation substituting flanking lysine	0.2778
p.A642V	TCGA-A5-A0G2	UCEC	TCGA	AGSTS	DEG_SPOP_SBC_1	642:646	Mutation altering degron motif	0.5825
p.A642V	TCGA-AX-A0J1	UCEC	TCGA	AGSTS	DEG_SPOP_SBC_1	642:646	Mutation altering degron motif	0.5825
p.A642V	DO41235	UCEC	ICGC	AGSTS	DEG_SPOP_SBC_1	642:646	Mutation altering degron motif	0.5825
p.A642V	DO41199	UCEC	ICGC	AGSTS	DEG_SPOP_SBC_1	642:646	Mutation altering degron motif	0.5825
p.A642V	SIDM00980	Gastric Carcinoma	GDSC	AGSTS	DEG_SPOP_SBC_1	642:646	Mutation altering degron motif	0.5825
p.A642V	ACH-000948	Gastric Cancer	CCLE	AGSTS	DEG_SPOP_SBC_1	642:646	Mutation altering degron motif	0.5825
p.A642V	23132-87	stomach	COSMIC	AGSTS	DEG_SPOP_SBC_1	642:646	Mutation altering degron motif	0.5825
p.V364I	TCGA-A5-A0G2	UCEC	TCGA	IVLHPD	LIG_APCC_ABBA_1	366:371	Mutation rewiring degron network	0.2778
p.V364I	TCGA-A5-A0G2	UCEC	TCGA	RIVLHPD	LIG_APCC_ABBAyCdc20_2	365:371	Mutation rewiring degron network	0.3056
p.V364I	DO41235	UCEC	ICGC	IVLHPD	LIG_APCC_ABBA_1	366:371	Mutation rewiring degron network	0.2778
p.V364I	DO41235	UCEC	ICGC	RIVLHPD	LIG_APCC_ABBAyCdc20_2	365:371	Mutation rewiring degron network	0.3056
p.G377A	TCGA-AY-6197	COAD	TCGA	IVLHPD	LIG_APCC_ABBA_1	366:371	Mutation rewiring degron network	0.1667
p.G377A	TCGA-AY-6197	COAD	TCGA	RIVLHPD	LIG_APCC_ABBAyCdc20_2	365:371	Mutation rewiring degron network	0.1667
p.G377A	DO9956	COAD	ICGC	IVLHPD	LIG_APCC_ABBA_1	366:371	Mutation rewiring degron network	0.1667
p.G377A	DO9956	COAD	ICGC	RIVLHPD	LIG_APCC_ABBAyCdc20_2	365:371	Mutation rewiring degron network	0.1667
p.K496R	TCGA-CA-6718	COAD	TCGA	TRLCLHNLP	DEG_APCC_DBOX_1	487:495	Mutation rewiring degron network	0.3056
p.K496R	DO7801	COAD	ICGC	TRLCLHNLP	DEG_APCC_DBOX_1	487:495	Mutation rewiring degron network	0.3056
p.P370L	TCGA-D3-A2J8	SKCM	TCGA	IVLHPD	LIG_APCC_ABBA_1	366:371	Mutation altering degron motif	0.6471
p.P370L	TCGA-D3-A2J8	SKCM	TCGA	RIVLHPD	LIG_APCC_ABBAyCdc20_2	365:371	Mutation altering degron motif	0.6471
p.P370L	DO37778	SKCM	ICGC	IVLHPD	LIG_APCC_ABBA_1	366:371	Mutation altering degron motif	0.6471
p.P370L	DO37778	SKCM	ICGC	RIVLHPD	LIG_APCC_ABBAyCdc20_2	365:371	Mutation altering degron motif	0.6471
p.E360K	TCGA-EO-A22R	UCEC	TCGA	IVLHPD	LIG_APCC_ABBA_1	366:371	Mutation rewiring degron network	0.1667
p.E360K	TCGA-EO-A22R	UCEC	TCGA	RIVLHPD	LIG_APCC_ABBAyCdc20_2	365:371	Mutation rewiring degron network	0.1944
p.E360K	DO42713	UCEC	ICGC	IVLHPD	LIG_APCC_ABBA_1	366:371	Mutation rewiring degron network	0.1667
p.E360K	DO42713	UCEC	ICGC	RIVLHPD	LIG_APCC_ABBAyCdc20_2	365:371	Mutation rewiring degron network	0.1944
p.R365C	TCGA-IB-7651	PAAD	TCGA	RIVLHPD	LIG_APCC_ABBAyCdc20_2	365:371	Mutation altering degron motif	0.8301
p.R365C	DO46657	PAAD	ICGC	RIVLHPD	LIG_APCC_ABBAyCdc20_2	365:371	Mutation altering degron motif	0.8301
p.P636L	TCGA-OR-A5J1	ACC	TCGA	AGSTS	DEG_SPOP_SBC_1	642:646	Mutation rewiring degron network	0.1667
p.S644C	TCGA-S5-A6DX	BLCA	TCGA	AGSTS	DEG_SPOP_SBC_1	642:646	Mutation altering degron motif	0.8652
p.S644C	DO51903	BLCA	ICGC	AGSTS	DEG_SPOP_SBC_1	642:646	Mutation altering degron motif	0.8652
p.L361I	DO229009	LICA	ICGC	IVLHPD	LIG_APCC_ABBA_1	366:371	Mutation rewiring degron network	0.1944
p.L361I	DO229009	LICA	ICGC	RIVLHPD	LIG_APCC_ABBAyCdc20_2	365:371	Mutation rewiring degron network	0.2222
p.K362R	DO231583	LINC	ICGC	IVLHPD	LIG_APCC_ABBA_1	366:371	Mutation substituting flanking lysine	0.3333
p.K362R	DO231583	LINC	ICGC	RIVLHPD	LIG_APCC_ABBAyCdc20_2	365:371	Mutation substituting flanking lysine	0.3611
p.A497G	DO231031	LUSC	ICGC	TRLCLHNLP	DEG_APCC_DBOX_1	487:495	Mutation rewiring degron network	0.2778
p.P635L	DO222662	MELA	ICGC	AGSTS	DEG_SPOP_SBC_1	642:646	Mutation rewiring degron network	0.1389
p.D479E	DO49451	PACA	ICGC	TRLCLHNLP	DEG_APCC_DBOX_1	487:495	Mutation rewiring degron network	0.1111
p.W647R	SIDM00573	Glioblastoma	GDSC	AGSTS	DEG_SPOP_SBC_1	642:646	Mutation rewiring degron network	0.3056
p.W647R	ACH-001606	Brain Cancer	CCLE	AGSTS	DEG_SPOP_SBC_1	642:646	Mutation rewiring degron network	0.3056
p.W647R	no-11	central nervous system	COSMIC	AGSTS	DEG_SPOP_SBC_1	642:646	Mutation rewiring degron network	0.3056
p.K633R	SIDM01113	Other Sarcomas	GDSC	AGSTS	DEG_SPOP_SBC_1	642:646	Mutation substituting flanking lysine	0.1944
p.K633R	ACH-000939	Sarcoma	CCLE	AGSTS	DEG_SPOP_SBC_1	642:646	Mutation substituting flanking lysine	0.1944
p.K633R	SK-UT-1	soft tissue	COSMIC	AGSTS	DEG_SPOP_SBC_1	642:646	Mutation substituting flanking lysine	0.1944
p.Y363F	SIDM01081	Oral Cavity Carcinoma	GDSC	IVLHPD	LIG_APCC_ABBA_1	366:371	Mutation rewiring degron network	0.25
p.Y363F	SIDM01081	Oral Cavity Carcinoma	GDSC	RIVLHPD	LIG_APCC_ABBAyCdc20_2	365:371	Mutation rewiring degron network	0.2778
p.Y363F	SCC-4	upper aerodigestive tract	COSMIC	IVLHPD	LIG_APCC_ABBA_1	366:371	Mutation rewiring degron network	0.25
p.Y363F	SCC-4	upper aerodigestive tract	COSMIC	RIVLHPD	LIG_APCC_ABBAyCdc20_2	365:371	Mutation rewiring degron network	0.2778
p.R486Q	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	TRLCLHNLP	DEG_APCC_DBOX_1	487:495	Mutation rewiring degron network	0.3056
p.R486Q	TE-9	oesophagus	COSMIC	TRLCLHNLP	DEG_APCC_DBOX_1	487:495	Mutation rewiring degron network	0.3056
p.R640T	ACH-000910	Breast Cancer	CCLE	AGSTS	DEG_SPOP_SBC_1	642:646	Mutation rewiring degron network	0.2778
p.K492R	SK-UT-1	soft tissue	COSMIC	TRLCLHNLP	DEG_APCC_DBOX_1	487:495	Mutation altering degron motif	0.7237
p.A501V	23132-87	stomach	COSMIC	TRLCLHNLP	DEG_APCC_DBOX_1	487:495	Mutation substituting flanking lysine	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RBM28

UniProt ID: Q9NW13

Entrez ID: 55131

Protein name: RNA-binding protein 28 (RNA-binding motif protein 28)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RBM28 in