DegronMD

Uniprot ID: Q9NW13

Source protein: RNA-binding protein 28

Source gene: RBM28

Class: LIG_APCC_ABBA_1

Location: 366:371

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.523

ASA_SCORE: 50

COIL: 0.5878

CONS_SCORE: 0.4821

DSS_SCORE: 0.168

HELIX: 0.0253

FCONS_SCORE: 0.8467

RIG_SCORE: 0.8126

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y363D	TCGA-20-0987	OV	TCGA	IVLHPD	LIG_APCC_ABBA_1	0.25
p.Y363D	DO31210	OV	ICGC	IVLHPD	LIG_APCC_ABBA_1	0.25
p.V364I	TCGA-A5-A0G2	UCEC	TCGA	IVLHPD	LIG_APCC_ABBA_1	0.2778
p.V364I	DO41235	UCEC	ICGC	IVLHPD	LIG_APCC_ABBA_1	0.2778
p.G377A	TCGA-AY-6197	COAD	TCGA	IVLHPD	LIG_APCC_ABBA_1	0.1667
p.G377A	DO9956	COAD	ICGC	IVLHPD	LIG_APCC_ABBA_1	0.1667
p.P370L	TCGA-D3-A2J8	SKCM	TCGA	IVLHPD	LIG_APCC_ABBA_1	0.6471
p.P370L	DO37778	SKCM	ICGC	IVLHPD	LIG_APCC_ABBA_1	0.6471
p.E360K	TCGA-EO-A22R	UCEC	TCGA	IVLHPD	LIG_APCC_ABBA_1	0.1667
p.E360K	DO42713	UCEC	ICGC	IVLHPD	LIG_APCC_ABBA_1	0.1667
p.L361I	DO229009	LICA	ICGC	IVLHPD	LIG_APCC_ABBA_1	0.1944
p.K362R	DO231583	LINC	ICGC	IVLHPD	LIG_APCC_ABBA_1	0.3333
p.Y363F	SIDM01081	Oral Cavity Carcinoma	GDSC	IVLHPD	LIG_APCC_ABBA_1	0.25
p.Y363F	SCC-4	upper_aerodigestive_tract	COSMIC	IVLHPD	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NW13	RNA-binding protein 28	LIG_APCC_ABBA_1	366:371	IVLHPD	APC,CDC20,FZR1	0.523	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons