DegronMD

Uniprot ID: Q9NW13

Source protein: RNA-binding protein 28

Source gene: RBM28

Class: LIG_APCC_ABBAyCdc20_2

Location: 365:371

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5164

ASA_SCORE: 52.4857

COIL: 0.5073

CONS_SCORE: 0.4822

DSS_SCORE: 0.1698

HELIX: 0.0221

FCONS_SCORE: 0.8554

RIG_SCORE: 0.8211

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R365S	TCGA-09-2044	OV	TCGA	RIVLHPD	LIG_APCC_ABBAyCdc20_2	0.7427
p.R365S	DO28923	OV	ICGC	RIVLHPD	LIG_APCC_ABBAyCdc20_2	0.7427
p.Y363D	TCGA-20-0987	OV	TCGA	RIVLHPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.Y363D	DO31210	OV	ICGC	RIVLHPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.V364I	TCGA-A5-A0G2	UCEC	TCGA	RIVLHPD	LIG_APCC_ABBAyCdc20_2	0.3056
p.V364I	DO41235	UCEC	ICGC	RIVLHPD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G377A	TCGA-AY-6197	COAD	TCGA	RIVLHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.G377A	DO9956	COAD	ICGC	RIVLHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.P370L	TCGA-D3-A2J8	SKCM	TCGA	RIVLHPD	LIG_APCC_ABBAyCdc20_2	0.6471
p.P370L	DO37778	SKCM	ICGC	RIVLHPD	LIG_APCC_ABBAyCdc20_2	0.6471
p.E360K	TCGA-EO-A22R	UCEC	TCGA	RIVLHPD	LIG_APCC_ABBAyCdc20_2	0.1944
p.E360K	DO42713	UCEC	ICGC	RIVLHPD	LIG_APCC_ABBAyCdc20_2	0.1944
p.R365C	TCGA-IB-7651	PAAD	TCGA	RIVLHPD	LIG_APCC_ABBAyCdc20_2	0.8301
p.R365C	DO46657	PAAD	ICGC	RIVLHPD	LIG_APCC_ABBAyCdc20_2	0.8301
p.L361I	DO229009	LICA	ICGC	RIVLHPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.K362R	DO231583	LINC	ICGC	RIVLHPD	LIG_APCC_ABBAyCdc20_2	0.3611
p.Y363F	SIDM01081	Oral Cavity Carcinoma	GDSC	RIVLHPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.Y363F	SCC-4	upper_aerodigestive_tract	COSMIC	RIVLHPD	LIG_APCC_ABBAyCdc20_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NW13	RNA-binding protein 28	LIG_APCC_ABBAyCdc20_2	365:371	RIVLHPD	APC,CDC20,FZR1	0.5164	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons