DegronMD

Uniprot ID: Q9NW13

Source protein: RNA-binding protein 28

Source gene: RBM28

Class: DEG_APCC_DBOX_1

Location: 487:495

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5021

ASA_SCORE: 28.7222

COIL: 0.3962

CONS_SCORE: 0.6954

DSS_SCORE: 0.1737

HELIX: 0.0227

FCONS_SCORE: 1.3581

RIG_SCORE: 0.8337

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K501R	TCGA-94-A5I4	LUSC	TCGA	TRLCLHNLP	DEG_APCC_DBOX_1	0.2778
p.K501R	DO219175	LUSC	ICGC	TRLCLHNLP	DEG_APCC_DBOX_1	0.2778
p.K496R	TCGA-CA-6718	COAD	TCGA	TRLCLHNLP	DEG_APCC_DBOX_1	0.3056
p.K496R	DO7801	COAD	ICGC	TRLCLHNLP	DEG_APCC_DBOX_1	0.3056
p.A497G	DO231031	LUSC	ICGC	TRLCLHNLP	DEG_APCC_DBOX_1	0.2778
p.D479E	DO49451	PACA	ICGC	TRLCLHNLP	DEG_APCC_DBOX_1	0.1111
p.R486Q	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	TRLCLHNLP	DEG_APCC_DBOX_1	0.3056
p.R486Q	TE-9	oesophagus	COSMIC	TRLCLHNLP	DEG_APCC_DBOX_1	0.3056
p.K492R	SK-UT-1	soft_tissue	COSMIC	TRLCLHNLP	DEG_APCC_DBOX_1	0.7237
p.A501V	23132-87	stomach	COSMIC	TRLCLHNLP	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NW13	RNA-binding protein 28	DEG_APCC_DBOX_1	487:495	TRLCLHNLP	APC,CDC20,FZR1	0.5021	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons