DegronMD - Q14541(HNF4G)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A112V	TCGA-77-7142	LUSC	TCGA	PGSST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.0556
p.A112V	DO26462	LUSC	ICGC	PGSST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.0556
p.H374L	TCGA-94-8490	LUSC	TCGA	PETPLPS	DEG_SCF_FBW7_1	371:377	Mutation altering degron motif	0.7313
p.H374L	DO52021	LUSC	ICGC	PETPLPS	DEG_SCF_FBW7_1	371:377	Mutation altering degron motif	0.7313
p.D134V	TCGA-AB-2922	LAML	TCGA	PGSST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1111
p.D134V	DO21427	LAML	ICGC	PGSST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1111
p.E117G	TCGA-BR-8361	STAD	TCGA	PGSST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1944
p.E117G	DO48032	STAD	ICGC	PGSST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1944
p.M114I	TCGA-DA-A960	SKCM	TCGA	PGSST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1111
p.M114I	TCGA-YG-AA3N	SKCM	TCGA	PGSST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1111
p.M114I	DO51298	SKCM	ICGC	PGSST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1111
p.M114I	DO219482	SKCM	ICGC	PGSST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1111
p.S382P	TCGA-DU-6392	LGG	TCGA	PETPLPS	DEG_SCF_FBW7_1	371:377	Mutation rewiring degron network	0.1944
p.S382P	DO22237	LGG	ICGC	PETPLPS	DEG_SCF_FBW7_1	371:377	Mutation rewiring degron network	0.1944
p.S382P	ACH-000044	Breast Cancer	CCLE	PETPLPS	DEG_SCF_FBW7_1	371:377	Mutation rewiring degron network	0.1944
p.G113R	TCGA-EB-A44P	SKCM	TCGA	PGSST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.0833
p.G113R	DO222837	MELA	ICGC	PGSST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.0833
p.G113R	DO47525	SKCM	ICGC	PGSST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.0833
p.G113R	SIDM00927	Small Cell Lung Carcinoma	GDSC	PGSST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.0833
p.G113R	ACH-000871	Lung Cancer	CCLE	PGSST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.0833
p.G113R	NCI-H510A	lung	COSMIC	PGSST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.0833
p.R125K	TCGA-EB-A5UN	SKCM	TCGA	PGSST	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.7237
p.R125K	TCGA-OD-A75X	SKCM	TCGA	PGSST	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.7237
p.R125K	DO47267	SKCM	ICGC	PGSST	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.7237
p.R125K	DO48601	SKCM	ICGC	PGSST	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.7237
p.H374N	TCGA-EE-A29Q	SKCM	TCGA	PETPLPS	DEG_SCF_FBW7_1	371:377	Mutation altering degron motif	0.7423
p.H374N	DO37866	SKCM	ICGC	PETPLPS	DEG_SCF_FBW7_1	371:377	Mutation altering degron motif	0.7423
p.H374Y	TCGA-EE-A2GE	SKCM	TCGA	PETPLPS	DEG_SCF_FBW7_1	371:377	Mutation altering degron motif	0.7229
p.H374Y	DO38016	SKCM	ICGC	PETPLPS	DEG_SCF_FBW7_1	371:377	Mutation altering degron motif	0.7229
p.A112T	TCGA-EE-A3AA	SKCM	TCGA	PGSST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.0556
p.A112T	DO222632	MELA	ICGC	PGSST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.0556
p.A112T	DO37571	SKCM	ICGC	PGSST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.0556
p.H375Y	TCGA-EE-A3J5	SKCM	TCGA	PETPLPS	DEG_SCF_FBW7_1	371:377	Mutation altering degron motif	0.7229
p.H375Y	DO220894	MELA	ICGC	PETPLPS	DEG_SCF_FBW7_1	371:377	Mutation altering degron motif	0.7229
p.H375Y	DO47331	SKCM	ICGC	PETPLPS	DEG_SCF_FBW7_1	371:377	Mutation altering degron motif	0.7229
p.H380R	TCGA-F7-A50I	HNSC	TCGA	PETPLPS	DEG_SCF_FBW7_1	371:377	Mutation rewiring degron network	0.25
p.H380R	DO44449	HNSC	ICGC	PETPLPS	DEG_SCF_FBW7_1	371:377	Mutation rewiring degron network	0.25
p.R125S	TCGA-FA-A82F	DLBC	TCGA	PGSST	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.7427
p.R125S	DO219891	DLBC	ICGC	PGSST	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.7427
p.D124Y	TCGA-KQ-A41N	BLCA	TCGA	PGSST	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.7325
p.D124Y	DO223588	BLCA	ICGC	PGSST	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.7325
p.R125I	TCGA-KQ-A41Q	BLCA	TCGA	PGSST	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.8102
p.R125I	DO223591	BLCA	ICGC	PGSST	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.8102
p.T387I	TCGA-MO-A47P	SARC	TCGA	PETPLPS	DEG_SCF_FBW7_1	371:377	Mutation rewiring degron network	0.0556
p.T387I	DO220219	SARC	ICGC	PETPLPS	DEG_SCF_FBW7_1	371:377	Mutation rewiring degron network	0.0556
p.R123H	DO233245	GACA	ICGC	PGSST	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.8244
p.K115E	DO233270	GACA	ICGC	PGSST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1389
p.M361I	DO228948	LICA	ICGC	PETPLPS	DEG_SCF_FBW7_1	371:377	Mutation rewiring degron network	0.0556
p.R123L	DO229029	LICA	ICGC	PGSST	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.8428
p.M377I	DO50970	LICA	ICGC	PETPLPS	DEG_SCF_FBW7_1	371:377	Mutation altering degron motif	0.7618
p.G113E	DO48723	LIRI	ICGC	PGSST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.0833
p.D369N	DO220885	MELA	ICGC	PETPLPS	DEG_SCF_FBW7_1	371:377	Mutation rewiring degron network	0.2778
p.L362I	DO232224	PBCA	ICGC	PETPLPS	DEG_SCF_FBW7_1	371:377	Mutation rewiring degron network	0.0833
p.Q383H	SIDM00633	Breast Carcinoma	GDSC	PETPLPS	DEG_SCF_FBW7_1	371:377	Mutation rewiring degron network	0.1667
p.G364D	SIDM00507	Other Solid Cancers	GDSC	PETPLPS	DEG_SCF_FBW7_1	371:377	Mutation rewiring degron network	0.1389
p.G364D	ACH-001490	Lung Cancer	CCLE	PETPLPS	DEG_SCF_FBW7_1	371:377	Mutation rewiring degron network	0.1389
p.G364D	COR-L321	NS	COSMIC	PETPLPS	DEG_SCF_FBW7_1	371:377	Mutation rewiring degron network	0.1389
p.S371N	SIDM01041	Esophageal Carcinoma	GDSC	PETPLPS	DEG_SCF_FBW7_1	371:377	Mutation altering degron motif	0.7069
p.S371N	ACH-001500	Esophageal Cancer	CCLE	PETPLPS	DEG_SCF_FBW7_1	371:377	Mutation altering degron motif	0.7069
p.S371N	FLO-1	oesophagus	COSMIC	PETPLPS	DEG_SCF_FBW7_1	371:377	Mutation altering degron motif	0.7069
p.E117D	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PGSST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1944
p.E117D	NCI-H2342	lung	COSMIC	PGSST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1944
p.R130K	SIDM00118	Colorectal Carcinoma	GDSC	PGSST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.2222
p.R130K	ACH-001081	Colon/Colorectal Cancer	CCLE	PGSST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.2222
p.R130K	HCC2998	large intestine	COSMIC	PGSST	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.2222
p.S382F	ACH-000044	Breast Cancer	CCLE	PETPLPS	DEG_SCF_FBW7_1	371:377	Mutation rewiring degron network	0.1944
p.G364S	ACH-000774	Lung Cancer	CCLE	PETPLPS	DEG_SCF_FBW7_1	371:377	Mutation rewiring degron network	0.1389
p.P371S	SW684	soft tissue	COSMIC	PETPLPS	DEG_SCF_FBW7_1	371:377	Mutation altering degron motif	0.6752
p.A365S	TE-4	oesophagus	COSMIC	PETPLPS	DEG_SCF_FBW7_1	371:377	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HNF4G

UniProt ID: Q14541

Entrez ID: 3174

Protein name: Hepatocyte nuclear factor 4-gamma (HNF-4-gamma) (Nuclear receptor subfamily 2 group A member 2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for HNF4G in