DegronMD

Uniprot ID: Q14541

Source protein: Hepatocyte nuclear factor 4-gamma

Source gene: HNF4G

Class: DEG_SCF_FBW7_1

Location: 371:377

E3 ligase: FBXW7

DEGRON score: 0.9758

ASA_SCORE: 94.3143

COIL: 0.9719

CONS_SCORE: 0.4092

DSS_SCORE: 0.787

HELIX: 0.0059

FCONS_SCORE: 1.1722

RIG_SCORE: 0.6236

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H374L	TCGA-94-8490	LUSC	TCGA	PETPLPS	DEG_SCF_FBW7_1	0.7313
p.H374L	DO52021	LUSC	ICGC	PETPLPS	DEG_SCF_FBW7_1	0.7313
p.S382P	TCGA-DU-6392	LGG	TCGA	PETPLPS	DEG_SCF_FBW7_1	0.1944
p.S382P	DO22237	LGG	ICGC	PETPLPS	DEG_SCF_FBW7_1	0.1944
p.S382P	ACH-000044	Breast Cancer	CCLE	PETPLPS	DEG_SCF_FBW7_1	0.1944
p.H374N	TCGA-EE-A29Q	SKCM	TCGA	PETPLPS	DEG_SCF_FBW7_1	0.7423
p.H374N	DO37866	SKCM	ICGC	PETPLPS	DEG_SCF_FBW7_1	0.7423
p.H374Y	TCGA-EE-A2GE	SKCM	TCGA	PETPLPS	DEG_SCF_FBW7_1	0.7229
p.H374Y	DO38016	SKCM	ICGC	PETPLPS	DEG_SCF_FBW7_1	0.7229
p.H375Y	TCGA-EE-A3J5	SKCM	TCGA	PETPLPS	DEG_SCF_FBW7_1	0.7229
p.H375Y	DO220894	MELA	ICGC	PETPLPS	DEG_SCF_FBW7_1	0.7229
p.H375Y	DO47331	SKCM	ICGC	PETPLPS	DEG_SCF_FBW7_1	0.7229
p.H380R	TCGA-F7-A50I	HNSC	TCGA	PETPLPS	DEG_SCF_FBW7_1	0.25
p.H380R	DO44449	HNSC	ICGC	PETPLPS	DEG_SCF_FBW7_1	0.25
p.T387I	TCGA-MO-A47P	SARC	TCGA	PETPLPS	DEG_SCF_FBW7_1	0.0556
p.T387I	DO220219	SARC	ICGC	PETPLPS	DEG_SCF_FBW7_1	0.0556
p.M361I	DO228948	LICA	ICGC	PETPLPS	DEG_SCF_FBW7_1	0.0556
p.M377I	DO50970	LICA	ICGC	PETPLPS	DEG_SCF_FBW7_1	0.7618
p.D369N	DO220885	MELA	ICGC	PETPLPS	DEG_SCF_FBW7_1	0.2778
p.L362I	DO232224	PBCA	ICGC	PETPLPS	DEG_SCF_FBW7_1	0.0833
p.Q383H	SIDM00633	Breast Carcinoma	GDSC	PETPLPS	DEG_SCF_FBW7_1	0.1667
p.G364D	SIDM00507	Other Solid Cancers	GDSC	PETPLPS	DEG_SCF_FBW7_1	0.1389
p.G364D	ACH-001490	Lung Cancer	CCLE	PETPLPS	DEG_SCF_FBW7_1	0.1389
p.G364D	COR-L321	NS	COSMIC	PETPLPS	DEG_SCF_FBW7_1	0.1389
p.S371N	SIDM01041	Esophageal Carcinoma	GDSC	PETPLPS	DEG_SCF_FBW7_1	0.7069
p.S371N	ACH-001500	Esophageal Cancer	CCLE	PETPLPS	DEG_SCF_FBW7_1	0.7069
p.S371N	FLO-1	oesophagus	COSMIC	PETPLPS	DEG_SCF_FBW7_1	0.7069
p.S382F	ACH-000044	Breast Cancer	CCLE	PETPLPS	DEG_SCF_FBW7_1	0.1944
p.G364S	ACH-000774	Lung Cancer	CCLE	PETPLPS	DEG_SCF_FBW7_1	0.1389
p.P371S	SW684	soft_tissue	COSMIC	PETPLPS	DEG_SCF_FBW7_1	0.6752
p.A365S	TE-4	oesophagus	COSMIC	PETPLPS	DEG_SCF_FBW7_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PETPLPS

Degron related mutations and impact score

Drug responses associated with HNF4G mutations

All proteins holding degron of PETPLPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14541	Hepatocyte nuclear factor 4-gamma	DEG_SCF_FBW7_1	371:377	PETPLPS	FBXW7	0.9758	More...