DegronMD - Q8IVI9(NOSTRIN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S424P	TCGA-56-7580	LUSC	TCGA	PGSST	DEG_SPOP_SBC_1	426:430	Mutation rewiring degron network	0.2778
p.S424P	DO27675	LUSC	ICGC	PGSST	DEG_SPOP_SBC_1	426:430	Mutation rewiring degron network	0.2778
p.E181K	TCGA-A5-A0G2	UCEC	TCGA	KRKLLNKLT	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.1389
p.E181K	DO41235	UCEC	ICGC	KRKLLNKLT	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.1389
p.E183K	TCGA-BF-AAP4	SKCM	TCGA	KRKLLNKLT	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.0833
p.E183K	DO219468	SKCM	ICGC	KRKLLNKLT	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.0833
p.P434L	TCGA-DF-A2KU	UCEC	TCGA	PGSST	DEG_SPOP_SBC_1	426:430	Mutation rewiring degron network	0.2222
p.P434L	DO223286	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	426:430	Mutation rewiring degron network	0.2222
p.E181A	TCGA-E6-A1LX	UCEC	TCGA	KRKLLNKLT	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.1389
p.E181A	DO41020	UCEC	ICGC	KRKLLNKLT	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.1389
p.K175Q	DO8730	COAD	ICGC	KRKLLNKLT	DEG_APCC_DBOX_1	166:174	Mutation rewiring degron network	0.3056
p.S420F	SIDM00087	Plasma Cell Myeloma	GDSC	PGSST	DEG_SPOP_SBC_1	426:430	Mutation rewiring degron network	0.1667
p.S420F	ACH-000817	Myeloma	CCLE	PGSST	DEG_SPOP_SBC_1	426:430	Mutation rewiring degron network	0.1667
p.S420F	RPMI-8226	haematopoietic and lymphoid tissue	COSMIC	PGSST	DEG_SPOP_SBC_1	426:430	Mutation rewiring degron network	0.1667
p.L423V	SIDM01084	Osteosarcoma	GDSC	PGSST	DEG_SPOP_SBC_1	426:430	Mutation rewiring degron network	0.25
p.L423V	ACH-000410	Bone Cancer	CCLE	PGSST	DEG_SPOP_SBC_1	426:430	Mutation rewiring degron network	0.25
p.L423V	Saos-2	bone	COSMIC	PGSST	DEG_SPOP_SBC_1	426:430	Mutation rewiring degron network	0.25
p.D435N	DG-75	haematopoietic and lymphoid tissue	COSMIC	PGSST	DEG_SPOP_SBC_1	426:430	Mutation rewiring degron network	0.1944
p.Q182K	NCI-H1651	lung	COSMIC	KRKLLNKLT	DEG_APCC_DBOX_1	166:174	Mutation substituting flanking lysine	0.2222
p.A421V	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PGSST	DEG_SPOP_SBC_1	426:430	Mutation rewiring degron network	0.1944
p.A417S	NB1	autonomic ganglia	COSMIC	PGSST	DEG_SPOP_SBC_1	426:430	Mutation substituting flanking lysine	0.1944
p.A173T	Ca-Ski	cervix	COSMIC	KRKLLNKLT	DEG_APCC_DBOX_1	166:174	Mutation altering degron motif	0.7139

Kaplan plot for NOSTRIN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NOSTRIN

UniProt ID: Q8IVI9

Entrez ID: 115677

Protein name: Nostrin (BM247 homolog) (Nitric oxide synthase traffic inducer) (Nitric oxide synthase trafficker) (eNOS-trafficking inducer)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NOSTRIN in