DegronMD

Uniprot ID: Q8IVI9

Source protein: Nostrin

Source gene: NOSTRIN

Class: DEG_APCC_DBOX_1

Location: 166:174

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7096

ASA_SCORE: 92.3667

COIL: 0.1133

CONS_SCORE: 0.5203

DSS_SCORE: 0.5043

HELIX: 0.8924

FCONS_SCORE: 1.0686

RIG_SCORE: 0.7668

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E181K	TCGA-A5-A0G2	UCEC	TCGA	KRKLLNKLT	DEG_APCC_DBOX_1	0.1389
p.E181K	DO41235	UCEC	ICGC	KRKLLNKLT	DEG_APCC_DBOX_1	0.1389
p.E183K	TCGA-BF-AAP4	SKCM	TCGA	KRKLLNKLT	DEG_APCC_DBOX_1	0.0833
p.E183K	DO219468	SKCM	ICGC	KRKLLNKLT	DEG_APCC_DBOX_1	0.0833
p.E181A	TCGA-E6-A1LX	UCEC	TCGA	KRKLLNKLT	DEG_APCC_DBOX_1	0.1389
p.E181A	DO41020	UCEC	ICGC	KRKLLNKLT	DEG_APCC_DBOX_1	0.1389
p.K175Q	DO8730	COAD	ICGC	KRKLLNKLT	DEG_APCC_DBOX_1	0.3056
p.Q182K	NCI-H1651	lung	COSMIC	KRKLLNKLT	DEG_APCC_DBOX_1	0.2222
p.A173T	Ca-Ski	cervix	COSMIC	KRKLLNKLT	DEG_APCC_DBOX_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVI9	Nostrin	DEG_APCC_DBOX_1	166:174	KRKLLNKLT	APC,CDC20,FZR1	0.7096	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons