DegronMD

Uniprot ID: P17948

Source protein: Vascular endothelial growth factor receptor 1

Source gene: FLT1

Class: DEG_SPOP_SBC_1

Location: 711:715

E3 ligase: SPOP

DEGRON score: 0.6649

ASA_SCORE: 52.56

COIL: 0.5508

CONS_SCORE: 0.4202

DSS_SCORE: 0.4236

HELIX: 0.0164

FCONS_SCORE: 0.9749

RIG_SCORE: 0.6986

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T711M	DO35226	PACA	ICGC	PGSST	DEG_SPOP_SBC_1	0.7423
p.T711M	DO42977	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	0.7423
p.T711M	DO41903	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	0.7423
p.S714N	DO50970	LICA	ICGC	PGSST	DEG_SPOP_SBC_1	0.7069
p.G712R	DO220911	MELA	ICGC	PGSST	DEG_SPOP_SBC_1	0.6457
p.S716L	DO222363	MELA	ICGC	PGSST	DEG_SPOP_SBC_1	0.3056
p.S716L	DO43907	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	0.3056
p.E719Q	ACH-002024	Colon/Colorectal Cancer	CCLE	PGSST	DEG_SPOP_SBC_1	0.2222
p.P720S	DO220073	SARC	ICGC	PGSST	DEG_SPOP_SBC_1	0.1944
p.P705T	DO229041	LICA	ICGC	PGSST	DEG_SPOP_SBC_1	0.1667
p.P705H	DO46542	OV	ICGC	PGSST	DEG_SPOP_SBC_1	0.1667
p.V721A	SIDM00193	Colorectal Carcinoma	GDSC	PGSST	DEG_SPOP_SBC_1	0.1667
p.V721A	ACH-000991	Colon/Colorectal Cancer	CCLE	PGSST	DEG_SPOP_SBC_1	0.1667
p.V721A	SNU-81	large_intestine	COSMIC	PGSST	DEG_SPOP_SBC_1	0.1667
p.E704K	DO50882	LICA	ICGC	PGSST	DEG_SPOP_SBC_1	0.1389
p.S723A	DO41361	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	0.1111
p.E723K	ACH-001408	Bladder Cancer	CCLE	PGSST	DEG_SPOP_SBC_1	0.1111

Showing 1 to 17 of 17 entries

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Drug responses associated with FLT1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00693	BLCA\|bladder	p.L1061V (No)	GDSC	Midostaurin	1.7165
SIDM00693	BLCA\|bladder	p.L1061V (No)	GDSC	Cabozantinib	32.8868
SIDM00693	BLCA\|bladder	p.L1061V (No)	GDSC	Linifanib	8.1207
SIDM00693	BLCA\|bladder	p.L1061V (No)	GDSC	Tivozanib	1.8598
SIDM00693	BLCA\|bladder	p.L1061V (No)	GDSC	Cediranib	147.05
SIDM00272	BRCA\|breast	p.S788F (No)	GDSC	Midostaurin	6.4387
SIDM00272	BRCA\|breast	p.S788F (No)	GDSC	Cabozantinib	33.5864
SIDM00272	BRCA\|breast	p.S788F (No)	GDSC	Linifanib	8.2605
SIDM00272	BRCA\|breast	p.S788F (No)	GDSC	Tivozanib	2.431
SIDM00272	BRCA\|breast	p.S788F (No)	GDSC	Cediranib	13.538
SIDM00673	BRCA\|breast	p.I623M (No)	GDSC	Midostaurin	1.6137
SIDM00673	BRCA\|breast	p.I623M (No)	GDSC	Cabozantinib	37.461
SIDM00673	BRCA\|breast	p.I623M (No)	GDSC	Linifanib	11.3311
SIDM00673	BRCA\|breast	p.I623M (No)	GDSC	Tivozanib	1.5913
SIDM00673	BRCA\|breast	p.I623M (No)	GDSC	Cediranib	28.435
SIDM00135	BRCA\|breast	p.C1018Y (No)	GDSC	Midostaurin	1.677
SIDM00135	BRCA\|breast	p.C1018Y (No)	GDSC	Cabozantinib	79.8364
SIDM00135	BRCA\|breast	p.C1018Y (No)	GDSC	Linifanib	16.1299
SIDM00135	BRCA\|breast	p.C1018Y (No)	GDSC	Tivozanib	2.0243
SIDM00135	BRCA\|breast	p.C1018Y (No)	GDSC	Cediranib	2.468
SIDM00892	BRCA\|breast	p.D987E (No)	GDSC	Midostaurin	7.5497
SIDM00892	BRCA\|breast	p.D987E (No)	GDSC	Cabozantinib	267.6604
SIDM00892	BRCA\|breast	p.D987E (No)	GDSC	Linifanib	32.0276
SIDM00892	BRCA\|breast	p.D987E (No)	GDSC	Tivozanib	6.3583
SIDM00892	BRCA\|breast	p.D987E (No)	GDSC	Cediranib	191.15

Showing 1 to 25 of 301 entries

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All proteins holding degron of PGSST

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96L96	Alpha-protein kinase 3	DEG_SPOP_SBC_1	77:81	PGSST	SPOP	0.9946	More...
Q9NZB2	Constitutive coactivator of PPAR-gamma-like protein 1	DEG_SPOP_SBC_1	454:458	PGSST	SPOP	0.9977	More...
O75956	Cyclin-dependent kinase 2-associated protein 2	DEG_SPOP_SBC_1	14:18	PGSST	SPOP	0.9967	More...
P18146	Early growth response protein 1	DEG_SPOP_SBC_1	477:481	PGSST	SPOP	0.7875	More...
P52799	Ephrin-B2	DEG_SPOP_SBC_1	204:208	PGSST	SPOP	0.573	More...
Q9C0E2	Exportin-4	DEG_SPOP_SBC_1	522:526	PGSST	SPOP	0.9799	More...
Q9UKD1	Glucocorticoid modulatory element-binding protein 2	DEG_SPOP_SBC_1	495:499	PGSST	SPOP	0.6991	More...
Q9UQC2	GRB2-associated-binding protein 2	DEG_SPOP_SBC_1	457:461	PGSST	SPOP	0.9866	More...
Q14541	Hepatocyte nuclear factor 4-gamma	DEG_SPOP_SBC_1	122:126	PGSST	SPOP	0.5473	More...
P49639	Homeobox protein Hox-A1	DEG_SPOP_SBC_1	323:327	PGSST	SPOP	0.9865	More...
Q13164	Mitogen-activated protein kinase 7	DEG_SPOP_SBC_1	676:680	PGSST	SPOP	0.9143	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	1949:1953	PGSST	SPOP	0.9296	More...
O95665	Neurotensin receptor type 2	DEG_SPOP_SBC_1	246:250	PGSST	SPOP	0.8617	More...
Q8IVI9	Nostrin	DEG_SPOP_SBC_1	426:430	PGSST	SPOP	0.6311	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	1118:1122	PGSST	SPOP	0.981	More...
Q5W0B1	ORC ubiquitin ligase 1	DEG_SPOP_SBC_1	302:306	PGSST	SPOP	0.9546	More...
Q96M63	Outer dynein arm-docking complex subunit 1	DEG_SPOP_SBC_1	660:664	PGSST	SPOP	0.9788	More...
O60741	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1	DEG_SPOP_SBC_1	758:762	PGSST	SPOP	0.9855	More...
Q96BN6	Primary cilium assembly protein FAM149B1	DEG_SPOP_SBC_1	386:390	PGSST	SPOP	0.948	More...
Q86UW9	Probable E3 ubiquitin-protein ligase DTX2	DEG_SPOP_SBC_1	294:298	PGSST	SPOP	0.9802	More...
Q9ULL5	Proline-rich protein 12	DEG_SPOP_SBC_1	137:141	PGSST	SPOP	0.967	More...
Q5T035	Putative uncharacterized protein C9orf129	DEG_SPOP_SBC_1	103:107	PGSST	SPOP	0.9971	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	759:763	PGSST	SPOP	0.9962	More...
Q8TER5	Rho guanine nucleotide exchange factor 40	DEG_SPOP_SBC_1	1488:1492	PGSST	SPOP	0.9989	More...
O94875	Sorbin and SH3 domain-containing protein 2	DEG_SPOP_SBC_1	285:289	PGSST	SPOP	0.99	More...

Showing 1 to 25 of 30 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGSST

Degron related mutations and impact score

Drug responses associated with FLT1 mutations

All proteins holding degron of PGSST