DegronMD - Q96BN6(FAM149B1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R419H	TCGA-AJ-A3EL	UCEC	TCGA	PISTS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.0833
p.R419H	DO41542	UCEC	ICGC	PISTS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.0833
p.R395Q	TCGA-E6-A1LX	UCEC	TCGA	PGSST	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.1944
p.R395Q	DO41020	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.1944
p.S432I	TCGA-R6-A6Y0	ESCA	TCGA	PISTS	DEG_SPOP_SBC_1	428:432	Mutation altering degron motif	0.7341
p.C435F	DO50575	BOCA	ICGC	PISTS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.25
p.C435F	SIDM00205	Ewing's Sarcoma	GDSC	PISTS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.25
p.C435F	ACH-002110	Bone Cancer	CCLE	PISTS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.25
p.C435F	EW-1	bone	COSMIC	PISTS	DEG_SPOP_SBC_1	428:432	Mutation rewiring degron network	0.25
p.T431S	DO225357	BRCA	ICGC	PISTS	DEG_SPOP_SBC_1	428:432	Mutation altering degron motif	0.6005
p.I391T	DO233072	GACA	ICGC	PGSST	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.3056
p.I391T	SIDM00516	Melanoma	GDSC	PGSST	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.3056
p.I391T	MZ7-mel	skin	COSMIC	PGSST	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.3056
p.S389G	DO233748	GACA	ICGC	PGSST	DEG_SPOP_SBC_1	386:390	Mutation altering degron motif	0.6993
p.R385S	DO229018	LICA	ICGC	PGSST	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.3056
p.R385S	DO229041	LICA	ICGC	PGSST	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.3056
p.C209F	DO229029	LICA	ICGC	AKSSS	DEG_SPOP_SBC_1	203:207	Mutation rewiring degron network	0.2778
p.D380Y	DO229036	LICA	ICGC	PGSST	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.1667
p.S205Y	DO51506	PACA	ICGC	AKSSS	DEG_SPOP_SBC_1	203:207	Mutation altering degron motif	0.712
p.M384T	SIDM00845	Burkitt's Lymphoma	GDSC	PGSST	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.2778
p.S393A	ACH-000387	Leukemia	CCLE	PGSST	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.25
p.Y195F	ACH-000659	Lung Cancer	CCLE	AKSSS	DEG_SPOP_SBC_1	203:207	Mutation rewiring degron network	0.1111
p.Y195F	ACH-001386	Lung Cancer	CCLE	AKSSS	DEG_SPOP_SBC_1	203:207	Mutation rewiring degron network	0.1111
p.W397G	SW684	soft tissue	COSMIC	PGSST	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.1389

Kaplan plot for FAM149B1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM149B1

UniProt ID: Q96BN6

Entrez ID: 317662

Protein name: Primary cilium assembly protein FAM149B1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM149B1 in