DegronMD

Uniprot ID: Q96BN6

Source protein: Primary cilium assembly protein FAM149B1

Source gene: FAM149B1

Class: DEG_SPOP_SBC_1

Location: 428:432

E3 ligase: SPOP

DEGRON score: 0.9122

ASA_SCORE: 82.22

COIL: 0.908

CONS_SCORE: 0.6058

DSS_SCORE: 0.6639

HELIX: 0.065

FCONS_SCORE: 1.1024

RIG_SCORE: 0.6486

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R419H	TCGA-AJ-A3EL	UCEC	TCGA	PISTS	DEG_SPOP_SBC_1	0.0833
p.R419H	DO41542	UCEC	ICGC	PISTS	DEG_SPOP_SBC_1	0.0833
p.S432I	TCGA-R6-A6Y0	ESCA	TCGA	PISTS	DEG_SPOP_SBC_1	0.7341
p.C435F	DO50575	BOCA	ICGC	PISTS	DEG_SPOP_SBC_1	0.25
p.C435F	SIDM00205	Ewing's Sarcoma	GDSC	PISTS	DEG_SPOP_SBC_1	0.25
p.C435F	ACH-002110	Bone Cancer	CCLE	PISTS	DEG_SPOP_SBC_1	0.25
p.C435F	EW-1	bone	COSMIC	PISTS	DEG_SPOP_SBC_1	0.25
p.T431S	DO225357	BRCA	ICGC	PISTS	DEG_SPOP_SBC_1	0.6005

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94855	Protein transport protein Sec24D	DEG_SPOP_SBC_1	111:115	PISTS	SPOP	0.9483	More...
P33981	Dual specificity protein kinase TTK	DEG_SPOP_SBC_1	438:442	PISTS	SPOP	0.9975	More...
Q13428	Treacle protein	DEG_SPOP_SBC_1	81:85	PISTS	SPOP	0.9924	More...
Q15762	CD226 antigen	DEG_SPOP_SBC_1	303:307	PISTS	SPOP	0.9768	More...
Q69YQ0	Cytospin-A	DEG_SPOP_SBC_1	891:895	PISTS	SPOP	0.9968	More...
Q6WKZ4	Rab11 family-interacting protein 1	DEG_SPOP_SBC_1	605:609	PISTS	SPOP	0.9332	More...
Q9C0F0	Putative Polycomb group protein ASXL3	DEG_SPOP_SBC_1	682:686	PISTS	SPOP	0.7746	More...
Q96BN6	Primary cilium assembly protein FAM149B1	DEG_SPOP_SBC_1	428:432	PISTS	SPOP	0.9122	More...
Q9Y5G3	Protocadherin gamma-B1	DEG_SPOP_SBC_1	282:286	PISTS	SPOP	0.9253	More...
Q96P64	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4	DEG_SPOP_SBC_1	331:335	PISTS	SPOP	0.9932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons