DegronMD

Uniprot ID: Q6WKZ4

Source protein: Rab11 family-interacting protein 1

Source gene: RAB11FIP1

Class: DEG_SPOP_SBC_1

Location: 605:609

E3 ligase: SPOP

DEGRON score: 0.9332

ASA_SCORE: 88.72

COIL: 0.9516

CONS_SCORE: 0.4567

DSS_SCORE: 0.4451

HELIX: 0.0172

FCONS_SCORE: 1.2663

RIG_SCORE: 0.644

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P605S	TCGA-21-1079	LUSC	TCGA	PISTS	DEG_SPOP_SBC_1	0.6752
p.P605S	DO26846	LUSC	ICGC	PISTS	DEG_SPOP_SBC_1	0.6752
p.S597C	TCGA-BL-A13I	BLCA	TCGA	PISTS	DEG_SPOP_SBC_1	0.1111
p.S597C	DO452	BLCA	ICGC	PISTS	DEG_SPOP_SBC_1	0.1111
p.A603T	TCGA-BT-A42C	BLCA	TCGA	PISTS	DEG_SPOP_SBC_1	0.2778
p.A603T	DO49725	BLCA	ICGC	PISTS	DEG_SPOP_SBC_1	0.2778
p.P605L	TCGA-D3-A2JF	SKCM	TCGA	PISTS	DEG_SPOP_SBC_1	0.7582
p.P605L	DO38153	SKCM	ICGC	PISTS	DEG_SPOP_SBC_1	0.7582
p.T606M	DO223732	CESC	ICGC	PISTS	DEG_SPOP_SBC_1	0.7423
p.R615C	DO230312	COCA	ICGC	PISTS	DEG_SPOP_SBC_1	0.1667
p.R615C	DO51761	STAD	ICGC	PISTS	DEG_SPOP_SBC_1	0.1667
p.S608R	DO228948	LICA	ICGC	PISTS	DEG_SPOP_SBC_1	0.7427
p.F612Y	DO219129	LUSC	ICGC	PISTS	DEG_SPOP_SBC_1	0.25
p.I602T	SIDM01015	Chronic Myelogenous Leukemia	GDSC	PISTS	DEG_SPOP_SBC_1	0.25
p.I602T	SIDM00672	Hepatocellular Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	0.25
p.I602T	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	0.25
p.I602T	SIDM00863	Burkitt's Lymphoma	GDSC	PISTS	DEG_SPOP_SBC_1	0.25
p.I602T	SIDM01173	Rhabdomyosarcoma	GDSC	PISTS	DEG_SPOP_SBC_1	0.25
p.I602T	SIDM00785	Acute Myeloid Leukemia	GDSC	PISTS	DEG_SPOP_SBC_1	0.25
p.I602T	SIDM01318	Hepatocellular Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	0.25
p.I602T	SIDM01686	Chronic Myelogenous Leukemia	GDSC	PISTS	DEG_SPOP_SBC_1	0.25
p.I602T	SIDM01409	Bladder Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	0.25
p.A603V	SIDM01265	Plasma Cell Myeloma	GDSC	PISTS	DEG_SPOP_SBC_1	0.2778
p.A603V	ACH-000763	Myeloma	CCLE	PISTS	DEG_SPOP_SBC_1	0.2778
p.A603V	MM1S	haematopoietic_and_lymphoid_tissue	COSMIC	PISTS	DEG_SPOP_SBC_1	0.2778
p.I612V	SIDM00654	Small Cell Lung Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	0.25
p.I612V	SIDM01187	Breast Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	0.25
p.I612V	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	0.25
p.I612V	SIDM01752	Pancreatic Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	0.25
p.F595L	SIDM00963	Breast Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	0.0556
p.F595L	ACH-000927	Breast Cancer	CCLE	PISTS	DEG_SPOP_SBC_1	0.0556
p.F595L	BT-474	breast	COSMIC	PISTS	DEG_SPOP_SBC_1	0.0556
p.E605V	ACH-001639	Leukemia	CCLE	PISTS	DEG_SPOP_SBC_1	0.7693
p.E605V	ROS-50	haematopoietic_and_lymphoid_tissue	COSMIC	PISTS	DEG_SPOP_SBC_1	0.7693

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94855	Protein transport protein Sec24D	DEG_SPOP_SBC_1	111:115	PISTS	SPOP	0.9483	More...
P33981	Dual specificity protein kinase TTK	DEG_SPOP_SBC_1	438:442	PISTS	SPOP	0.9975	More...
Q13428	Treacle protein	DEG_SPOP_SBC_1	81:85	PISTS	SPOP	0.9924	More...
Q15762	CD226 antigen	DEG_SPOP_SBC_1	303:307	PISTS	SPOP	0.9768	More...
Q69YQ0	Cytospin-A	DEG_SPOP_SBC_1	891:895	PISTS	SPOP	0.9968	More...
Q6WKZ4	Rab11 family-interacting protein 1	DEG_SPOP_SBC_1	605:609	PISTS	SPOP	0.9332	More...
Q9C0F0	Putative Polycomb group protein ASXL3	DEG_SPOP_SBC_1	682:686	PISTS	SPOP	0.7746	More...
Q96BN6	Primary cilium assembly protein FAM149B1	DEG_SPOP_SBC_1	428:432	PISTS	SPOP	0.9122	More...
Q9Y5G3	Protocadherin gamma-B1	DEG_SPOP_SBC_1	282:286	PISTS	SPOP	0.9253	More...
Q96P64	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4	DEG_SPOP_SBC_1	331:335	PISTS	SPOP	0.9932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PISTS

Degron related mutations and impact score

Drug responses associated with RAB11FIP1 mutations

All proteins holding degron of PISTS