TTK
UniProt ID: P33981
Entrez ID: 7272
Protein name: Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Phosphorylates proteins on serine, threonine, and tyrosine (PubMed:18243099, PubMed:29162720). Probably associated with cell proliferation (PubMed:18243099). Phosphorylates MAD1L1 to promote mitotic checkpoint signaling (PubMed:29162720). Essential for chromosome alignment by enhancing AUR...
FUNCTION: Phosphorylates proteins on serine, threonine, and tyrosine (PubMed:18243099, PubMed:29162720). Probably associated with cell proliferation (PubMed:18243099). Phosphorylates MAD1L1 to promote mitotic checkpoint signaling (PubMed:29162720). Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint (PubMed:18243099). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:29162720}.
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GO - Biological processes (BP):
chromosome segregation [GO:0007059]; chromosome separation [GO:0051304]; female meiosis chromosome segregation [GO:0016321]; meiotic spindle assembly checkpoint signaling [GO:0033316]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mitotic spindle organization [GO:0007052]; peptidyl-ser...
chromosome segregation [GO:0007059]; chromosome separation [GO:0051304]; female meiosis chromosome segregation [GO:0016321]; meiotic spindle assembly checkpoint signaling [GO:0033316]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mitotic spindle organization [GO:0007052]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; protein autophosphorylation [GO:0046777]; protein localization to kinetochore [GO:0034501]; protein localization to meiotic spindle midzone [GO:1903096]; spindle organization [GO:0007051]
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GO - Molecular function (MF):
ATP binding [GO:0005524]; identical protein binding [GO:0042802]; kinetochore binding [GO:0043515]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein serine/threonine kinase activity [GO:0004674]; protein serine kinase activity [GO:0106310]; protein tyrosine kinase activity [GO...
ATP binding [GO:0005524]; identical protein binding [GO:0042802]; kinetochore binding [GO:0043515]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein serine/threonine kinase activity [GO:0004674]; protein serine kinase activity [GO:0106310]; protein tyrosine kinase activity [GO:0004713]
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GO - Cellular component (CC):
cytoplasm [GO:0005737]; kinetochore [GO:0000776]; membrane [GO:0016020]; nucleus [GO:0005634]; spindle [GO:0005819]...
cytoplasm [GO:0005737]; kinetochore [GO:0000776]; membrane [GO:0016020]; nucleus [GO:0005634]; spindle [GO:0005819]
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TTK
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*NOTE: the Kaplan plots were collected from OncoLnc