DegronMD - Q6WKZ4(RAB11FIP1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P605S	TCGA-21-1079	LUSC	TCGA	PISTS	DEG_SPOP_SBC_1	605:609	Mutation altering degron motif	0.6752
p.P605S	DO26846	LUSC	ICGC	PISTS	DEG_SPOP_SBC_1	605:609	Mutation altering degron motif	0.6752
p.S190T	TCGA-24-2280	OV	TCGA	DSGSDT	DEG_SCF_TRCP1_1	183:188	Mutation blocking phosphorylation signal	0.7222
p.P727S	TCGA-2W-A8YY	CESC	TCGA	SPSSGE	DEG_Kelch_Keap1_1	717:722	Mutation rewiring degron network	0.1944
p.P727S	DO223732	CESC	ICGC	SPSSGE	DEG_Kelch_Keap1_1	717:722	Mutation rewiring degron network	0.1944
p.D984G	TCGA-73-A9RS	LUAD	TCGA	AKSST	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1944
p.D984G	DO51193	LUAD	ICGC	AKSST	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1944
p.Q714L	TCGA-86-A4JF	LUAD	TCGA	SPSSGE	DEG_Kelch_Keap1_1	717:722	Mutation rewiring degron network	0.25
p.Q714L	DO45317	LUAD	ICGC	SPSSGE	DEG_Kelch_Keap1_1	717:722	Mutation rewiring degron network	0.25
p.Q981H	TCGA-A5-A0GA	UCEC	TCGA	AKSST	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1111
p.Q981H	DO43763	UCEC	ICGC	AKSST	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1111
p.S1099F	TCGA-AA-3663	COAD	TCGA	TSLDNPVPSP	DEG_COP1_1	1089:1098	Mutation rewiring degron network	0.3056
p.S1099F	DO9346	COAD	ICGC	TSLDNPVPSP	DEG_COP1_1	1089:1098	Mutation rewiring degron network	0.3056
p.A492V	TCGA-AB-2828	LAML	TCGA	LNLFED	LIG_APCC_ABBA_1	502:507	Mutation rewiring degron network	0.0556
p.S991L	TCGA-AJ-A3EK	UCEC	TCGA	AKSST	DEG_SPOP_SBC_1	989:993	Mutation altering degron motif	0.7667
p.S991L	DO41584	UCEC	ICGC	AKSST	DEG_SPOP_SBC_1	989:993	Mutation altering degron motif	0.7667
p.E425D	TCGA-AO-A03M	BRCA	TCGA	RRSSLLSLM	DEG_APCC_DBOX_1	432:440	Mutation rewiring degron network	0.1389
p.P1083S	TCGA-B5-A3FC	UCEC	TCGA	TSLDNPVPSP	DEG_COP1_1	1089:1098	Mutation rewiring degron network	0.1667
p.P1083S	DO41871	UCEC	ICGC	TSLDNPVPSP	DEG_COP1_1	1089:1098	Mutation rewiring degron network	0.1667
p.S597C	TCGA-BL-A13I	BLCA	TCGA	PISTS	DEG_SPOP_SBC_1	605:609	Mutation rewiring degron network	0.1111
p.S597C	DO452	BLCA	ICGC	PISTS	DEG_SPOP_SBC_1	605:609	Mutation rewiring degron network	0.1111
p.A603T	TCGA-BT-A42C	BLCA	TCGA	PISTS	DEG_SPOP_SBC_1	605:609	Mutation rewiring degron network	0.2778
p.A603T	DO49725	BLCA	ICGC	PISTS	DEG_SPOP_SBC_1	605:609	Mutation rewiring degron network	0.2778
p.D1092V	TCGA-CN-4741	HNSC	TCGA	TSLDNPVPSP	DEG_COP1_1	1089:1098	Mutation altering degron motif	0.7785
p.D1092V	DO14313	HNSC	ICGC	TSLDNPVPSP	DEG_COP1_1	1089:1098	Mutation altering degron motif	0.7785
p.P605L	TCGA-D3-A2JF	SKCM	TCGA	PISTS	DEG_SPOP_SBC_1	605:609	Mutation altering degron motif	0.7582
p.P605L	DO38153	SKCM	ICGC	PISTS	DEG_SPOP_SBC_1	605:609	Mutation altering degron motif	0.7582
p.K448N	TCGA-D7-A4YV	STAD	TCGA	RRSSLLSLM	DEG_APCC_DBOX_1	432:440	Mutation blocking ubiquitination signal	0.5556
p.S1082N	TCGA-DF-A2KU	UCEC	TCGA	TSLDNPVPSP	DEG_COP1_1	1089:1098	Mutation rewiring degron network	0.1389
p.S1082N	DO223286	UCEC	ICGC	TSLDNPVPSP	DEG_COP1_1	1089:1098	Mutation rewiring degron network	0.1389
p.P1083Q	TCGA-DU-5854	LGG	TCGA	TSLDNPVPSP	DEG_COP1_1	1089:1098	Mutation rewiring degron network	0.1667
p.P1083Q	DO22466	LGG	ICGC	TSLDNPVPSP	DEG_COP1_1	1089:1098	Mutation rewiring degron network	0.1667
p.P707Q	TCGA-ER-A2NH	SKCM	TCGA	SPSSGE	DEG_Kelch_Keap1_1	717:722	Mutation rewiring degron network	0.0556
p.P707Q	DO47683	SKCM	ICGC	SPSSGE	DEG_Kelch_Keap1_1	717:722	Mutation rewiring degron network	0.0556
p.S435Y	TCGA-IB-7651	PAAD	TCGA	RRSSLLSLM	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.712
p.P1087A	TCGA-IZ-A6M8	KIRP	TCGA	TSLDNPVPSP	DEG_COP1_1	1089:1098	Mutation rewiring degron network	0.2778
p.P1087A	DO48489	KIRP	ICGC	TSLDNPVPSP	DEG_COP1_1	1089:1098	Mutation rewiring degron network	0.2778
p.E430K	TCGA-UC-A7PF	CESC	TCGA	RRSSLLSLM	DEG_APCC_DBOX_1	432:440	Mutation rewiring degron network	0.2778
p.S1084R	DO224855	BRCA	ICGC	TSLDNPVPSP	DEG_COP1_1	1089:1098	Mutation rewiring degron network	0.1944
p.A437G	DO4455	BRCA	ICGC	RRSSLLSLM	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.754
p.T606M	DO223732	CESC	ICGC	PISTS	DEG_SPOP_SBC_1	605:609	Mutation altering degron motif	0.7423
p.R615C	DO230312	COCA	ICGC	PISTS	DEG_SPOP_SBC_1	605:609	Mutation rewiring degron network	0.1667
p.R615C	DO51761	STAD	ICGC	PISTS	DEG_SPOP_SBC_1	605:609	Mutation rewiring degron network	0.1667
p.K184N	DO22237	LGG	ICGC	DSGSDT	DEG_SCF_TRCP1_1	183:188	Mutation altering degron motif	0.6918
p.S608R	DO228948	LICA	ICGC	PISTS	DEG_SPOP_SBC_1	605:609	Mutation altering degron motif	0.7427
p.Q724K	DO228974	LICA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	717:722	Mutation rewiring degron network	0.2778
p.P196Q	DO228985	LICA	ICGC	DSGSDT	DEG_SCF_TRCP1_1	183:188	Mutation rewiring degron network	0.1111
p.P1096T	DO229025	LICA	ICGC	TSLDNPVPSP	DEG_COP1_1	1089:1098	Mutation altering degron motif	0.7031
p.L730I	DO229026	LICA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	717:722	Mutation rewiring degron network	0.1111
p.D1092E	DO229045	LICA	ICGC	TSLDNPVPSP	DEG_COP1_1	1089:1098	Mutation altering degron motif	0.5647
p.Y177C	DO26434	LUSC	ICGC	DSGSDT	DEG_SCF_TRCP1_1	183:188	Mutation rewiring degron network	0.1667
p.F612Y	DO219129	LUSC	ICGC	PISTS	DEG_SPOP_SBC_1	605:609	Mutation rewiring degron network	0.25
p.G1002D	DO52679	MALY	ICGC	AKSST	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.0833
p.R434K	DO222727	MELA	ICGC	RRSSLLSLM	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.7237
p.R434K	DO38028	SKCM	ICGC	RRSSLLSLM	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.7237
p.P710S	DO27943	ORCA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	717:722	Mutation rewiring degron network	0.1389
p.R434T	DO32113	OV	ICGC	RRSSLLSLM	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.7876
p.P707L	DO33128	PACA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	717:722	Mutation rewiring degron network	0.0556
p.P707L	SIDM00210	Ovarian Carcinoma	GDSC	SPSSGE	DEG_Kelch_Keap1_1	717:722	Mutation rewiring degron network	0.0556
p.S1000P	DO232224	PBCA	ICGC	AKSST	DEG_SPOP_SBC_1	989:993	Mutation rewiring degron network	0.1389
p.G173V	DO229068	PRAD	ICGC	DSGSDT	DEG_SCF_TRCP1_1	183:188	Mutation rewiring degron network	0.0556
p.P432S	DO220239	SARC	ICGC	RRSSLLSLM	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.6752
p.S194Y	DO218857	SKCA	ICGC	DSGSDT	DEG_SCF_TRCP1_1	183:188	Mutation rewiring degron network	0.1667
p.P198L	DO37487	SKCM	ICGC	DSGSDT	DEG_SCF_TRCP1_1	183:188	Mutation rewiring degron network	0.0556
p.S197F	DO38045	SKCM	ICGC	DSGSDT	DEG_SCF_TRCP1_1	183:188	Mutation rewiring degron network	0.0833
p.R439C	DO223907	SKCM	ICGC	RRSSLLSLM	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.8301
p.P433L	DO39363	THCA	ICGC	RRSSLLSLM	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.7582
p.A183V	DO41644	UCEC	ICGC	DSGSDT	DEG_SCF_TRCP1_1	183:188	Mutation altering degron motif	0.6936
p.G185C	DO42873	UCEC	ICGC	DSGSDT	DEG_SCF_TRCP1_1	183:188	Mutation altering degron motif	0.76
p.P1085L	SIDM02050	Colorectal Carcinoma	GDSC	TSLDNPVPSP	DEG_COP1_1	1089:1098	Mutation rewiring degron network	0.2222
p.L1091P	SIDM00422	Hodgkin's Lymphoma	GDSC	TSLDNPVPSP	DEG_COP1_1	1089:1098	Mutation altering degron motif	0.6471
p.L1091P	ACH-001203	Lymphoma	CCLE	TSLDNPVPSP	DEG_COP1_1	1089:1098	Mutation altering degron motif	0.6471
p.L1091P	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	TSLDNPVPSP	DEG_COP1_1	1089:1098	Mutation altering degron motif	0.6471
p.I602T	SIDM01015	Chronic Myelogenous Leukemia	GDSC	PISTS	DEG_SPOP_SBC_1	605:609	Mutation rewiring degron network	0.25
p.I602T	SIDM00672	Hepatocellular Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	605:609	Mutation rewiring degron network	0.25
p.I602T	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	605:609	Mutation rewiring degron network	0.25
p.I602T	SIDM00863	Burkitt's Lymphoma	GDSC	PISTS	DEG_SPOP_SBC_1	605:609	Mutation rewiring degron network	0.25
p.I602T	SIDM01173	Rhabdomyosarcoma	GDSC	PISTS	DEG_SPOP_SBC_1	605:609	Mutation rewiring degron network	0.25
p.I602T	SIDM00785	Acute Myeloid Leukemia	GDSC	PISTS	DEG_SPOP_SBC_1	605:609	Mutation rewiring degron network	0.25
p.I602T	SIDM01318	Hepatocellular Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	605:609	Mutation rewiring degron network	0.25
p.I602T	SIDM01686	Chronic Myelogenous Leukemia	GDSC	PISTS	DEG_SPOP_SBC_1	605:609	Mutation rewiring degron network	0.25
p.I602T	SIDM01409	Bladder Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	605:609	Mutation rewiring degron network	0.25
p.S195R	SIDM00458	Acute Myeloid Leukemia	GDSC	DSGSDT	DEG_SCF_TRCP1_1	183:188	Mutation rewiring degron network	0.1389
p.S195R	ACH-000751	Leukemia	CCLE	DSGSDT	DEG_SCF_TRCP1_1	183:188	Mutation rewiring degron network	0.1389
p.S195R	OCI-M1	haematopoietic and lymphoid tissue	COSMIC	DSGSDT	DEG_SCF_TRCP1_1	183:188	Mutation rewiring degron network	0.1389
p.A603V	SIDM01265	Plasma Cell Myeloma	GDSC	PISTS	DEG_SPOP_SBC_1	605:609	Mutation rewiring degron network	0.2778
p.A603V	ACH-000763	Myeloma	CCLE	PISTS	DEG_SPOP_SBC_1	605:609	Mutation rewiring degron network	0.2778
p.A603V	MM1S	haematopoietic and lymphoid tissue	COSMIC	PISTS	DEG_SPOP_SBC_1	605:609	Mutation rewiring degron network	0.2778
p.Q509L	SIDM01119	Other Solid Cancers	GDSC	LNLFED	LIG_APCC_ABBA_1	502:507	Mutation rewiring degron network	0.2778
p.Q509L	ACH-000775	Lung Cancer	CCLE	LNLFED	LIG_APCC_ABBA_1	502:507	Mutation rewiring degron network	0.2778
p.Q509L	NCI-H727	lung	COSMIC	LNLFED	LIG_APCC_ABBA_1	502:507	Mutation rewiring degron network	0.2778
p.I612V	SIDM00654	Small Cell Lung Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	605:609	Mutation rewiring degron network	0.25
p.I612V	SIDM01187	Breast Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	605:609	Mutation rewiring degron network	0.25
p.I612V	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	605:609	Mutation rewiring degron network	0.25
p.I612V	SIDM01752	Pancreatic Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	605:609	Mutation rewiring degron network	0.25
p.D1092H	SIDM00040	Gastric Carcinoma	GDSC	TSLDNPVPSP	DEG_COP1_1	1089:1098	Mutation altering degron motif	0.7688
p.D1092H	SIDM00171	Colorectal Carcinoma	GDSC	TSLDNPVPSP	DEG_COP1_1	1089:1098	Mutation altering degron motif	0.7688
p.D1092H	TMK-1	stomach	COSMIC	TSLDNPVPSP	DEG_COP1_1	1089:1098	Mutation altering degron motif	0.7688
p.P1083L	SIDM01113	Other Sarcomas	GDSC	TSLDNPVPSP	DEG_COP1_1	1089:1098	Mutation rewiring degron network	0.1667
p.F595L	SIDM00963	Breast Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	605:609	Mutation rewiring degron network	0.0556
p.F595L	ACH-000927	Breast Cancer	CCLE	PISTS	DEG_SPOP_SBC_1	605:609	Mutation rewiring degron network	0.0556
p.F595L	BT-474	breast	COSMIC	PISTS	DEG_SPOP_SBC_1	605:609	Mutation rewiring degron network	0.0556
p.P517R	SIDM00930	Osteosarcoma	GDSC	LNLFED	LIG_APCC_ABBA_1	502:507	Mutation rewiring degron network	0.0556
p.P517R	ACH-001715	Bone Cancer	CCLE	LNLFED	LIG_APCC_ABBA_1	502:507	Mutation rewiring degron network	0.0556
p.P517R	CAL-72	bone	COSMIC	LNLFED	LIG_APCC_ABBA_1	502:507	Mutation rewiring degron network	0.0556
p.A492T	SIDM00217	Colorectal Carcinoma	GDSC	LNLFED	LIG_APCC_ABBA_1	502:507	Mutation rewiring degron network	0.0556
p.A492T	ACH-000999	Colon/Colorectal Cancer	CCLE	LNLFED	LIG_APCC_ABBA_1	502:507	Mutation rewiring degron network	0.0556
p.A492T	SNU-1040	large intestine	COSMIC	LNLFED	LIG_APCC_ABBA_1	502:507	Mutation rewiring degron network	0.0556
p.T441M	SIDM00150	Colorectal Carcinoma	GDSC	RRSSLLSLM	DEG_APCC_DBOX_1	432:440	Mutation blocking phosphorylation signal	0.75
p.E514A	ACH-000389	Brain Cancer	CCLE	LNLFED	LIG_APCC_ABBA_1	502:507	Mutation rewiring degron network	0.1389
p.E605V	ACH-001639	Leukemia	CCLE	PISTS	DEG_SPOP_SBC_1	605:609	Mutation altering degron motif	0.7693
p.E605V	ROS-50	haematopoietic and lymphoid tissue	COSMIC	PISTS	DEG_SPOP_SBC_1	605:609	Mutation altering degron motif	0.7693
p.S434L	NCI-H2347	lung	COSMIC	RRSSLLSLM	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.7667
p.D446N	COR-L95	lung	COSMIC	RRSSLLSLM	DEG_APCC_DBOX_1	432:440	Mutation rewiring degron network	0.1667
p.L178V	OCI-AML3	haematopoietic and lymphoid tissue	COSMIC	DSGSDT	DEG_SCF_TRCP1_1	183:188	Mutation substituting flanking lysine	0.3056
p.A437T	HEC-1	endometrium	COSMIC	RRSSLLSLM	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.7139
p.P192L	CAL-12T	lung	COSMIC	DSGSDT	DEG_SCF_TRCP1_1	183:188	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RAB11FIP1

UniProt ID: Q6WKZ4

Entrez ID: 80223

Protein name: Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RAB11FIP1 in