DegronMD

Uniprot ID: Q6WKZ4

Source protein: Rab11 family-interacting protein 1

Source gene: RAB11FIP1

Class: DEG_APCC_DBOX_1

Location: 432:440

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9914

ASA_SCORE: 95.5

COIL: 0.7007

CONS_SCORE: 0.4511

DSS_SCORE: 0.6532

HELIX: 0.2704

FCONS_SCORE: 1.0684

RIG_SCORE: 0.6658

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E425D	TCGA-AO-A03M	BRCA	TCGA	RRSSLLSLM	DEG_APCC_DBOX_1	0.1389
p.K448N	TCGA-D7-A4YV	STAD	TCGA	RRSSLLSLM	DEG_APCC_DBOX_1	0.5556
p.S435Y	TCGA-IB-7651	PAAD	TCGA	RRSSLLSLM	DEG_APCC_DBOX_1	0.712
p.E430K	TCGA-UC-A7PF	CESC	TCGA	RRSSLLSLM	DEG_APCC_DBOX_1	0.2778
p.A437G	DO4455	BRCA	ICGC	RRSSLLSLM	DEG_APCC_DBOX_1	0.754
p.R434K	DO222727	MELA	ICGC	RRSSLLSLM	DEG_APCC_DBOX_1	0.7237
p.R434K	DO38028	SKCM	ICGC	RRSSLLSLM	DEG_APCC_DBOX_1	0.7237
p.R434T	DO32113	OV	ICGC	RRSSLLSLM	DEG_APCC_DBOX_1	0.7876
p.P432S	DO220239	SARC	ICGC	RRSSLLSLM	DEG_APCC_DBOX_1	0.6752
p.R439C	DO223907	SKCM	ICGC	RRSSLLSLM	DEG_APCC_DBOX_1	0.8301
p.P433L	DO39363	THCA	ICGC	RRSSLLSLM	DEG_APCC_DBOX_1	0.7582
p.T441M	SIDM00150	Colorectal Carcinoma	GDSC	RRSSLLSLM	DEG_APCC_DBOX_1	0.75
p.S434L	NCI-H2347	lung	COSMIC	RRSSLLSLM	DEG_APCC_DBOX_1	0.7667
p.D446N	COR-L95	lung	COSMIC	RRSSLLSLM	DEG_APCC_DBOX_1	0.1667
p.A437T	HEC-1	endometrium	COSMIC	RRSSLLSLM	DEG_APCC_DBOX_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6WKZ4	Rab11 family-interacting protein 1	DEG_APCC_DBOX_1	432:440	RRSSLLSLM	APC,CDC20,FZR1	0.9914	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons