DegronMD

Uniprot ID: Q6WKZ4

Source protein: Rab11 family-interacting protein 1

Source gene: RAB11FIP1

Class: DEG_SPOP_SBC_1

Location: 989:993

E3 ligase: SPOP

DEGRON score: 0.7562

ASA_SCORE: 89.62

COIL: 0.8546

CONS_SCORE: 0.2544

DSS_SCORE: 0.5624

HELIX: 0.0956

FCONS_SCORE: 0.9564

RIG_SCORE: 0.7185

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D984G	TCGA-73-A9RS	LUAD	TCGA	AKSST	DEG_SPOP_SBC_1	0.1944
p.D984G	DO51193	LUAD	ICGC	AKSST	DEG_SPOP_SBC_1	0.1944
p.Q981H	TCGA-A5-A0GA	UCEC	TCGA	AKSST	DEG_SPOP_SBC_1	0.1111
p.Q981H	DO43763	UCEC	ICGC	AKSST	DEG_SPOP_SBC_1	0.1111
p.S991L	TCGA-AJ-A3EK	UCEC	TCGA	AKSST	DEG_SPOP_SBC_1	0.7667
p.S991L	DO41584	UCEC	ICGC	AKSST	DEG_SPOP_SBC_1	0.7667
p.G1002D	DO52679	MALY	ICGC	AKSST	DEG_SPOP_SBC_1	0.0833
p.S1000P	DO232224	PBCA	ICGC	AKSST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94885	SAM and SH3 domain-containing protein 1	DEG_SPOP_SBC_1	747:751	AKSST	SPOP	0.7998	More...
Q14684	Ribosomal RNA processing protein 1 homolog B	DEG_SPOP_SBC_1	659:663	AKSST	SPOP	0.9985	More...
Q6WKZ4	Rab11 family-interacting protein 1	DEG_SPOP_SBC_1	989:993	AKSST	SPOP	0.7562	More...
Q9Y2R2	Tyrosine-protein phosphatase non-receptor type 22	DEG_SPOP_SBC_1	372:376	AKSST	SPOP	0.8922	More...
Q5SZJ8	BEN domain-containing protein 6	DEG_SPOP_SBC_1	214:218	AKSST	SPOP	0.9533	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons