DegronMD - Q9Y2R2(PTPN22)

GO - Biological processes (BP): autophagy [GO:0006914]; cellular response to muramyl dipeptide [GO:0071225]; lipid metabolic process [GO:0006629]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of autophagy [GO:0010507]; negative regulation of gene expression [GO:0010629]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070433]; negative regulation of p38MAPK cascade [GO:1903753]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of tumor necrosis factor production [GO:0032720]; peptidyl-tyrosine dephosphorylation [GO:0035335]; phosphoanandamide dephosphorylation [GO:0035644]; positive regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000566]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of granzyme B production [GO:0071663]; positive regulation of interferon-gamma production [GO:0032729]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; positive regulation of toll-like receptor 7 signaling pathway [GO:0034157]; positive regulation of toll-like receptor 9 signaling pathway [GO:0034165]; positive regulation of type I interferon production [GO:0032481]; protein dephosphorylation [GO:0006470]; regulation of B cell receptor signaling pathway [GO:0050855]; regulation of innate immune response [GO:0045088]; regulation of natural killer cell proliferation [GO:0032817]; regulation of NIK/NF-kappaB signaling [GO:1901222]; response to lipopolysaccharide [GO:0032496]; T cell differentiation [GO:0030217]; T cell receptor signaling pathway [GO:0050852] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L381P	TCGA-21-5783	LUSC	TCGA	AKSST	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1944
p.L381P	DO27437	LUSC	ICGC	AKSST	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1944
p.L369V	TCGA-2W-A8YY	CESC	TCGA	AKSST	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.25
p.L369V	DO223732	CESC	ICGC	AKSST	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.25
p.S465I	TCGA-A5-A0G1	UCEC	TCGA	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation altering degron motif	0.623
p.S465I	TCGA-AA-A010	COAD	TCGA	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation altering degron motif	0.623
p.S465I	DO42472	UCEC	ICGC	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation altering degron motif	0.623
p.S749C	TCGA-AJ-A3EK	UCEC	TCGA	LKTPGKS	DEG_SCF_FBW7_1	739:745	Mutation rewiring degron network	0.2222
p.S749C	DO41584	UCEC	ICGC	LKTPGKS	DEG_SCF_FBW7_1	739:745	Mutation rewiring degron network	0.2222
p.S479C	TCGA-AR-A0TX	BRCA	TCGA	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation rewiring degron network	0.0556
p.S479C	DO1663	BRCA	ICGC	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation rewiring degron network	0.0556
p.L381V	TCGA-AR-A0TX	BRCA	TCGA	AKSST	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1944
p.L381V	DO1663	BRCA	ICGC	AKSST	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1944
p.K744Q	TCGA-B5-A11E	UCEC	TCGA	LKTPGKS	DEG_SCF_FBW7_1	739:745	Mutation altering degron motif	0.5833
p.K744Q	DO41644	UCEC	ICGC	LKTPGKS	DEG_SCF_FBW7_1	739:745	Mutation altering degron motif	0.5833
p.E467G	TCGA-BS-A0UF	UCEC	TCGA	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation altering degron motif	0.7199
p.E467G	DO41488	UCEC	ICGC	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation altering degron motif	0.7199
p.E467G	SIDM00538	Esophageal Carcinoma	GDSC	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation altering degron motif	0.7199
p.E467G	ACH-001497	Esophageal Cancer	CCLE	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation altering degron motif	0.7199
p.E467G	ESO51	oesophagus	COSMIC	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation altering degron motif	0.7199
p.E462D	TCGA-BS-A0UF	UCEC	TCGA	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation rewiring degron network	0.25
p.E462D	DO41488	UCEC	ICGC	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation rewiring degron network	0.25
p.Q475E	TCGA-BT-A2LA	BLCA	TCGA	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation rewiring degron network	0.1667
p.Q475E	TCGA-GV-A3QI	BLCA	TCGA	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation rewiring degron network	0.1667
p.Q475E	DO470	BLCA	ICGC	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation rewiring degron network	0.1667
p.Q475E	DO561	BLCA	ICGC	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation rewiring degron network	0.1667
p.E467K	TCGA-D3-A2JH	SKCM	TCGA	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation altering degron motif	0.7022
p.E467K	DO47263	SKCM	ICGC	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation altering degron motif	0.7022
p.E467K	SIDM00545	Melanoma	GDSC	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation altering degron motif	0.7022
p.E467K	ACH-000987	Skin Cancer	CCLE	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation altering degron motif	0.7022
p.E467K	Mewo	skin	COSMIC	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation altering degron motif	0.7022
p.P742L	TCGA-D3-A8GR	SKCM	TCGA	LKTPGKS	DEG_SCF_FBW7_1	739:745	Mutation altering degron motif	0.7582
p.P742L	TCGA-ER-A19N	SKCM	TCGA	LKTPGKS	DEG_SCF_FBW7_1	739:745	Mutation altering degron motif	0.7582
p.P742L	DO37452	SKCM	ICGC	LKTPGKS	DEG_SCF_FBW7_1	739:745	Mutation altering degron motif	0.7582
p.P742L	DO51247	SKCM	ICGC	LKTPGKS	DEG_SCF_FBW7_1	739:745	Mutation altering degron motif	0.7582
p.E382K	TCGA-DK-A6AW	BLCA	TCGA	AKSST	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1667
p.E382K	DO48566	BLCA	ICGC	AKSST	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1667
p.E382K	SIDM00185	Melanoma	GDSC	AKSST	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1667
p.E382K	ACH-002152	Skin Cancer	CCLE	AKSST	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1667
p.E382K	LB2518-MEL	skin	COSMIC	AKSST	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1667
p.P371T	TCGA-EE-A29E	SKCM	TCGA	AKSST	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.3056
p.P371T	DO37831	SKCM	ICGC	AKSST	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.3056
p.S732L	TCGA-EE-A2MR	SKCM	TCGA	LKTPGKS	DEG_SCF_FBW7_1	739:745	Mutation rewiring degron network	0.1389
p.S732L	DO37819	SKCM	ICGC	LKTPGKS	DEG_SCF_FBW7_1	739:745	Mutation rewiring degron network	0.1389
p.S745C	TCGA-EY-A1G8	UCEC	TCGA	LKTPGKS	DEG_SCF_FBW7_1	739:745	Mutation altering degron motif	0.7541
p.S745C	DO43578	UCEC	ICGC	LKTPGKS	DEG_SCF_FBW7_1	739:745	Mutation altering degron motif	0.7541
p.S479Y	TCGA-FI-A2D5	UCEC	TCGA	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation rewiring degron network	0.0556
p.S479Y	DO41331	UCEC	ICGC	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation rewiring degron network	0.0556
p.F469C	TCGA-FI-A2D5	UCEC	TCGA	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation altering degron motif	0.5996
p.F469C	DO41331	UCEC	ICGC	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation altering degron motif	0.5996
p.G743E	TCGA-GN-A266	SKCM	TCGA	LKTPGKS	DEG_SCF_FBW7_1	739:745	Mutation altering degron motif	0.6087
p.G743E	TCGA-RP-A693	SKCM	TCGA	LKTPGKS	DEG_SCF_FBW7_1	739:745	Mutation altering degron motif	0.6087
p.G743E	DO37432	SKCM	ICGC	LKTPGKS	DEG_SCF_FBW7_1	739:745	Mutation altering degron motif	0.6087
p.G743E	DO51268	SKCM	ICGC	LKTPGKS	DEG_SCF_FBW7_1	739:745	Mutation altering degron motif	0.6087
p.S565C	DO561	BLCA	ICGC	PTSST	DEG_SPOP_SBC_1	568:572	Mutation rewiring degron network	0.25
p.P740A	DO228008	LAML	ICGC	LKTPGKS	DEG_SCF_FBW7_1	739:745	Mutation altering degron motif	0.7503
p.A335G	DO228974	LICA	ICGC	PKSTT	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.2778
p.T333K	DO228971	LICA	ICGC	PKSTT	DEG_SPOP_SBC_1	329:333	Mutation altering degron motif	0.7306
p.A335E	DO229045	LICA	ICGC	PKSTT	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.2778
p.S374L	DO222875	MELA	ICGC	AKSST	DEG_SPOP_SBC_1	372:376	Mutation altering degron motif	0.7667
p.G742E	DO229453	SKCA	ICGC	LKTPGKS	DEG_SCF_FBW7_1	739:745	Mutation altering degron motif	0.7199
p.P748S	DO47973	STAD	ICGC	LKTPGKS	DEG_SCF_FBW7_1	739:745	Mutation rewiring degron network	0.25
p.R744S	DO38272	STAD	ICGC	LKTPGKS	DEG_SCF_FBW7_1	739:745	Mutation altering degron motif	0.7427
p.R744M	DO38272	STAD	ICGC	LKTPGKS	DEG_SCF_FBW7_1	739:745	Mutation altering degron motif	0.8632
p.H370N	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	AKSST	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.2778
p.H370N	SIDM00072	Non-Cancerous	GDSC	AKSST	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.2778
p.H370N	SIDM01164	Glioma	GDSC	AKSST	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.2778
p.H370N	SIDM00779	Colorectal Carcinoma	GDSC	AKSST	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.2778
p.H370N	SIDM00710	Small Cell Lung Carcinoma	GDSC	AKSST	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.2778
p.H370N	SIDM01050	Biliary Tract Carcinoma	GDSC	AKSST	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.2778
p.H370N	SIDM00070	B-Cell Non-Hodgkin's Lymphoma	GDSC	AKSST	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.2778
p.H370N	SIDM01193	Glioma	GDSC	AKSST	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.2778
p.H370N	SIDM01759	Hodgkin's Lymphoma	GDSC	AKSST	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.2778
p.H370N	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	AKSST	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.2778
p.K750N	SIDM01163	Non-Small Cell Lung Carcinoma	GDSC	LKTPGKS	DEG_SCF_FBW7_1	739:745	Mutation substituting flanking lysine	0.3056
p.K750N	SIDM01649	Non-Cancerous	GDSC	LKTPGKS	DEG_SCF_FBW7_1	739:745	Mutation substituting flanking lysine	0.3056
p.K750N	SIDM01218	Other Solid Cancers	GDSC	LKTPGKS	DEG_SCF_FBW7_1	739:745	Mutation substituting flanking lysine	0.3056
p.K750N	SIDM00118	Colorectal Carcinoma	GDSC	LKTPGKS	DEG_SCF_FBW7_1	739:745	Mutation substituting flanking lysine	0.3056
p.K750N	SIDM00184	Melanoma	GDSC	LKTPGKS	DEG_SCF_FBW7_1	739:745	Mutation substituting flanking lysine	0.3056
p.K750N	SIDM01613	Colorectal Carcinoma	GDSC	LKTPGKS	DEG_SCF_FBW7_1	739:745	Mutation substituting flanking lysine	0.3056
p.R748G	SIDM01023	Acute Myeloid Leukemia	GDSC	LKTPGKS	DEG_SCF_FBW7_1	739:745	Mutation rewiring degron network	0.25
p.R748G	SIDM01168	Colorectal Carcinoma	GDSC	LKTPGKS	DEG_SCF_FBW7_1	739:745	Mutation rewiring degron network	0.25
p.S751N	SIDM00477	Esophageal Carcinoma	GDSC	LKTPGKS	DEG_SCF_FBW7_1	739:745	Mutation blocking phosphorylation signal	0.6111
p.S751N	SIDM01003	T-Lymphoblastic Leukemia	GDSC	LKTPGKS	DEG_SCF_FBW7_1	739:745	Mutation blocking phosphorylation signal	0.6111
p.Q456E	SIDM01087	Melanoma	GDSC	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation rewiring degron network	0.0833
p.Q456E	SIDM01118	Small Cell Lung Carcinoma	GDSC	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation rewiring degron network	0.0833
p.Q456E	SIDM00511	Small Cell Lung Carcinoma	GDSC	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation rewiring degron network	0.0833
p.Q456E	SIDM00628	Breast Carcinoma	GDSC	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation rewiring degron network	0.0833
p.F469L	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation altering degron motif	0.587
p.F469L	ACH-000824	Esophageal Cancer	CCLE	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation altering degron motif	0.587
p.F469L	KYSE-510	oesophagus	COSMIC	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation altering degron motif	0.587
p.R458T	SIDM00603	Head and Neck Carcinoma	GDSC	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation rewiring degron network	0.1389
p.R458T	ACH-001543	Head and Neck Cancer	CCLE	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation rewiring degron network	0.1389
p.R458T	KOSC-2	upper aerodigestive tract	COSMIC	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation rewiring degron network	0.1389
p.S325Y	SIDM01368	Gastric Carcinoma	GDSC	PKSTT	DEG_SPOP_SBC_1	329:333	Mutation blocking phosphorylation signal	0.6667
p.S325Y	ACH-000255	Gastric Cancer	CCLE	PKSTT	DEG_SPOP_SBC_1	329:333	Mutation blocking phosphorylation signal	0.6667
p.S377Y	SIDM01611	Endometrial Carcinoma	GDSC	AKSST	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.3056
p.S377Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	AKSST	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.3056
p.S386I	SIDM01782	Oral Cavity Carcinoma	GDSC	AKSST	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.0556
p.S386I	ACH-000723	Head and Neck Cancer	CCLE	AKSST	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.0556
p.T741I	SIDM01588	Endometrial Carcinoma	GDSC	LKTPGKS	DEG_SCF_FBW7_1	739:745	Mutation altering degron motif	0.8189
p.T741I	ACH-000993	Endometrial/Uterine Cancer	CCLE	LKTPGKS	DEG_SCF_FBW7_1	739:745	Mutation altering degron motif	0.8189
p.T376I	ACH-001377	Pancreatic Cancer	CCLE	AKSST	DEG_SPOP_SBC_1	372:376	Mutation altering degron motif	0.7078
p.T376I	ACH-001380	Pancreatic Cancer	CCLE	AKSST	DEG_SPOP_SBC_1	372:376	Mutation altering degron motif	0.7078
p.R331T	KOSC-2	upper aerodigestive tract	COSMIC	PKSTT	DEG_SPOP_SBC_1	329:333	Mutation altering degron motif	0.7876
p.Y376C	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	AKSST	DEG_SPOP_SBC_1	372:376	Mutation altering degron motif	0.7087
p.Y376C	HCC-78	lung	COSMIC	AKSST	DEG_SPOP_SBC_1	372:376	Mutation altering degron motif	0.7087
p.I337M	SNU-81	large intestine	COSMIC	PKSTT	DEG_SPOP_SBC_1	329:333	Mutation blocking ubiquitination signal	0.6667
p.E340G	ESO51	oesophagus	COSMIC	PKSTT	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.1389
p.N479T	MCC13	skin	COSMIC	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation rewiring degron network	0.0556
p.A379T	COR-L88	lung	COSMIC	AKSST	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.25
p.F342L	KYSE-510	oesophagus	COSMIC	PKSTT	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.0833
p.P568S	RL95-2	endometrium	COSMIC	PTSST	DEG_SPOP_SBC_1	568:572	Mutation altering degron motif	0.6752
p.P375S	HT-115	large intestine	COSMIC	AKSST	DEG_SPOP_SBC_1	372:376	Mutation altering degron motif	0.6752
p.Y479C	HCC-78	lung	COSMIC	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation rewiring degron network	0.0556
p.Y479C	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation rewiring degron network	0.0556
p.E340K	Mewo	skin	COSMIC	PKSTT	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.1389
p.P560L	VMRC-RCW	kidney	COSMIC	PTSST	DEG_SPOP_SBC_1	568:572	Mutation rewiring degron network	0.1111
p.V458A	SN12C	kidney	COSMIC	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation rewiring degron network	0.1389
p.E327K	LB2518-MEL	skin	COSMIC	PKSTT	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.2778
p.S456Y	SNU-81	large intestine	COSMIC	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation rewiring degron network	0.0833
p.S469Y	LNCaP-Clone-FGC	prostate	COSMIC	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation altering degron motif	0.712
p.T574A	SNU-1040	large intestine	COSMIC	PTSST	DEG_SPOP_SBC_1	568:572	Mutation rewiring degron network	0.2778
p.E478K	TMK-1	stomach	COSMIC	SKENF	DEG_APCC_KENBOX_2	465:469	Mutation rewiring degron network	0.0833
p.S378C	CAL-85-1	breast	COSMIC	AKSST	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.2778
p.D562N	NCI-H727	lung	COSMIC	PTSST	DEG_SPOP_SBC_1	568:572	Mutation rewiring degron network	0.1667
p.S366Y	LNCaP-Clone-FGC	prostate	COSMIC	AKSST	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1667
p.P581R	HCC2218	breast	COSMIC	PTSST	DEG_SPOP_SBC_1	568:572	Mutation rewiring degron network	0.0833
p.S559Y	SNU-81	large intestine	COSMIC	PTSST	DEG_SPOP_SBC_1	568:572	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PTPN22

UniProt ID: Q9Y2R2

Entrez ID: 26191

Protein name: Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP) (PEST-domain phosphatase) (PEP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PTPN22 in