DegronMD

Uniprot ID: Q9Y2R2

Source protein: Tyrosine-protein phosphatase non-receptor type 22

Source gene: PTPN22

Class: DEG_SPOP_SBC_1

Location: 329:333

E3 ligase: SPOP

DEGRON score: 0.828

ASA_SCORE: 85.04

COIL: 0.7796

CONS_SCORE: 0.2457

DSS_SCORE: 0.6286

HELIX: 0.1924

FCONS_SCORE: 0.9309

RIG_SCORE: 0.6793

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A335G	DO228974	LICA	ICGC	PKSTT	DEG_SPOP_SBC_1	0.2778
p.T333K	DO228971	LICA	ICGC	PKSTT	DEG_SPOP_SBC_1	0.7306
p.A335E	DO229045	LICA	ICGC	PKSTT	DEG_SPOP_SBC_1	0.2778
p.S325Y	SIDM01368	Gastric Carcinoma	GDSC	PKSTT	DEG_SPOP_SBC_1	0.6667
p.S325Y	ACH-000255	Gastric Cancer	CCLE	PKSTT	DEG_SPOP_SBC_1	0.6667
p.R331T	KOSC-2	upper_aerodigestive_tract	COSMIC	PKSTT	DEG_SPOP_SBC_1	0.7876
p.I337M	SNU-81	large_intestine	COSMIC	PKSTT	DEG_SPOP_SBC_1	0.6667
p.E340G	ESO51	oesophagus	COSMIC	PKSTT	DEG_SPOP_SBC_1	0.1389
p.F342L	KYSE-510	oesophagus	COSMIC	PKSTT	DEG_SPOP_SBC_1	0.0833
p.E340K	Mewo	skin	COSMIC	PKSTT	DEG_SPOP_SBC_1	0.1389
p.E327K	LB2518-MEL	skin	COSMIC	PKSTT	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07359	Platelet glycoprotein Ib alpha chain	DEG_SPOP_SBC_1	376:380	PKSTT	SPOP	0.9058	More...
Q14966	Zinc finger protein 638	DEG_SPOP_SBC_1	1518:1522	PKSTT	SPOP	0.7644	More...
Q52LJ0	Protein FAM98B	DEG_SPOP_SBC_1	160:164	PKSTT	SPOP	0.9796	More...
Q9BZW7	Testis-specific gene 10 protein	DEG_SPOP_SBC_1	89:93	PKSTT	SPOP	0.765	More...
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_SPOP_SBC_1	515:519	PKSTT	SPOP	0.9463	More...
Q9Y2R2	Tyrosine-protein phosphatase non-receptor type 22	DEG_SPOP_SBC_1	329:333	PKSTT	SPOP	0.828	More...
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SPOP_SBC_1	1324:1328	PKSTT	SPOP	0.9941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons